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Biomedical subjects

I H Page

Publications and source records attributed to I H Page.

At least 91 records · Page 5Linked to original sources
PubMed1966

6-hydroxylation: effect on the psychotropic potency of tryptamines.

6-Hydroxy-5-methoxy-N,N dimethyltryptamine and 5-methoxy-N, N-dimnethyltryptamine were synthesized and their psychotropic effects compared on trained rats in a Skinner box. The nonhydroxylated form was the more po tent. The metabolism of 5-methoxytryp tophol acetate ester was also studied to determine whether hydroxylation might occur in other than the six position with exogenous indoles. One metabolite was formed, with properties of a hydroxy-5-methoxyindole-3-acetic acid, which proved on chromatography not to be the 6-hydroxy structural isomer. Phar macologic and metabolic studies suggest that psychotropic activity of trypt amines may result from metabolites other than the 6-hydroxylated forms.

Animals↗
PubMed1966

Stable complex of fibrinogen and fibrin.

Fibrin-stabilizing factor acts on monomeric fibrin combined with fibrinogen to form a stable complex that is soluble at physiologic pH and ionic strength. The complex has been isolated by chromatography on agarose gel and characterized by sedimentation rate near 24 S(w.20) at both pH 5.3 and 7.4, by coagulability when treated with thrombin, and by content of fibrinopeptides. Formation of the complex could provide a pathway for solubilization of monomeric fibrin produced in circulating blood.

Chemical Phenomena↗