Search PubMed⌕ Search

Biomedical subjects

I H Bourne

Publications and source records attributed to I H Bourne.

At least 19 recordsLinked to original sources
PubMed1992

Treatment of leg ulcers.

A system of treatment of venous leg ulcers by leg elevation, dry gauze dressings and inelastic bandage boots is compared with regimens in which a series of elastic bandage boots are applied to squeeze oedema from swollen ulcerated legs.

Bandages↗
PubMed1984

An hypothesis concerning the role of the Golgi apparatus in the phenomenon of memory.

The hypothesis considers the anatomy and physiology of the memory-storing neuron from the viewpoint that an eccentrically placed nucleus with a Golgi Apparatus situated between it and the proximate cell membrane could be the mechanism for the storage and retrieval of experience and thought processes. Metabolites which enter the Golgi Apparatus are filtered and refined before being discharged from the surface which faces the cell membrane. They travel by the shortest route to a special location on the nearest part of the cell membrane. At this "favoured spot" the action potential is reactivated before the metabolites reach other parts of the membrane. Afferent impulses arriving via the synapses at the "favoured spot" and its tributary dendrites have priority controls the specific polarity of the cell, enabling it to record, store and reproduce the memory of its initial stimulus. Reinforcing stimuli cause the eccentric nucleus and Golgi Apparatus to move nearer to the favoured spot. This mechanism could be the basis of memory. The hypothesis may be applied to other observed phenomenon of brain function and might be submitted to experiment confirmation.

Animals↗
PubMed1980

The role of the brain cell nuclei in the function of memory.

The neurophysiological basis of memory may lie in the significance of eccentric cell nuclei found in neurons in certain parts of the brain. Embryonic nerve cells are spherical with central nuclei, whereas fully developed neurons in specific parts of the adult brain are non-spherical with eccentric nuclei. The hypothesis proposes that the mechanism of the sodium pump of the cell membrane is affected by the proximity of the nucleus. Molecules from the nucleus travel through the protoplasm of the cell to the deep surface of the cell membrane. The polarity of the individual cell is determined by that part of the cell membrane which is nearest the nucleus. This "Favoured Spot" is always re-energised first after the sodium pump has been discharged by a stimulus from a synaptic knob. After depolarisation, stimuli arriving at the favoured spot have priority over stimuli arriving simultaneously at any other parts of the cell, for when the latter are still in a refractory phase, the favoured spot is already re-energised to its exitatory state.

Adult↗