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Biomedical subjects

I Guttman

Publications and source records attributed to I Guttman.

6 recordsLinked to original sources
PubMed1995

Dependent masking and system life data analysis: Bayesian inference for two-component systems.

Data from field operations of a system is often used to estimate the reliability of components. Under ideal circumstances, this system field data contains the time to failure along with information on the exact component responsible for the system failure. However, in many cases, the exact component causing the failure of the system cannot be identified, and is considered to be masked. Previously developed models for estimation of component reliability from masked system life data have been based upon the assumption that masking occurs independently of the true cause of system failure. In this paper we develop a Bayesian methodology for estimating component reliabilities from masked system life data when the probability of masking is dependent upon the true cause of system failure. The Bayesian approach is illustrated for the case of a two-component system of exponentially distributed components.

Bayes Theorem↗
PubMed1981

Carcinoembryonic-like substance in breast fluid discharge in benign and malignant breast disease and in milk of lactating women.

In a search for a simple noninvasive test for early detection of breast cancer, radioimmunoassay was used to determine carcinoembryonic (CEA) levels in the serum and breast fluid of 26 women presenting with spontaneous breast discharge, and in the serum and milk of 34 postpartum lactating women. In 54 milk samples from 34 healthy nursing mothers, the mean CEA level was 62.6 +/- 49.2 ng/ml (mean +/- SD) (range 5 to 252 ng/ml). The highest levels were found during the first days after delivery. Serum CEA levels measured in 18 of the 34 mothers were negative in 12 cases and normal (10 +/- 5.3 ng/ml) in six. No correlation was found between CEA levels in milk and those in serum. In the women with spontaneous breast fluid discharge, CEA levels in the breast fluid measured less than 300 ng/ml in 10 cases, 300 to 1,000 ng/ml in 9 cases and greater than 1,000 ng/ml in 7 cases. None of the 19 women with CEA values below 1,000 ng/ml had a malignancy. Four of the seven women with the highest CEA levels were found to have breast cancer. Serum CEA levels were within the normal range in both the malignant and nonmalignant cases. We conclude that CEA levels are markedly elevated in breast fluid discharges in nonlactating women, and that the highest levels may be associated with malignancy.

Adult↗
PubMed1981

Markedly elevated creatinine phosphokinase, cotton wool spots, and pericarditis in a patient with leptospirosis.

We are reporting a patient with acute leptospirosis whose creatinine phosphokinase was markedly elevated secondary to an associated myositis. In patients presenting with acute hepatitis, an elevated creatinine phosphokinase should suggest the diagnosis of leptospirosis. Our patient's course of illness was made unusual by the appearance of cotton wool spots, previously unreported in leptospirosis as well as by pericarditis in the absence of uremia. This illustrates our ever widening recognition of the clinical manifestations of leptospirosis.

Adult↗