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Biomedical subjects

I Gruev

Publications and source records attributed to I Gruev.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Hyperprolactinemia in chronic kidney failure patients].

The determination of the endocrine state of the patients with chronic renal insufficiency is of significance because of the endocrine sexual disorders often observed in those patients. According to literature data, hyperprolactinemia in combination with gonad dysfunction is often observed in the sera of those patients. Hyperprolactinemia was established, with the present study, in the examined 47 patients (18 females and 29 males) with chronic renal insufficiency, the normal physiological difference in prolactin level depending on sex, being eliminated in those patients. The hyperprolactinemia in the patients examined, as compared with the prolactin level in a control group of healthy subjects (10 females and 12 males) is statistically significant (p less than 0.01). Very likely that hyperprolactinemia in the patients with chronic renal insufficiency is complexly conditioned by the disturbed regulation and disturbed degradation and elimination.

Adult↗
PubMed1982

[Possibilities of combined treatment of diffuse collagenous glomerulonephritis].

Combined corticosteroid, immunosuppressive and anticoagulant treatment was performed to 17 patients with various histological forms of collagenous glomerulonephritis, 14--with disseminated lupus erythematodes, 1--with periartheritis nodosa and 2--with Schönlein-Henoch disease. The immunosuppressive treatment was carried out for an average of 14.62 months, the corticosteroid treatment--an average of 17 months and the anticoagulant--18.12 months. In 6 patients the corticosteroid treatment was initiated with a pulse of 30 mg methylprednisolone in the course of 3-10 days, and in the rest of the patients--with an initial dose of 60 mg prednisolone. The anticoagulant treatment was, at first, carried out with heparin 30,000 U daily, and later with acenocoumarol and the immunosuppressive--with azathioprin--100 mg daily. The term of treatment and observation is from 6 to 63 months, an average of 25-82 months. The treatment was discontinued in eight patients. Very good effect (complete clinical and laboratory remission) was obtained in seven patients--41.18 per cent, good effect (clinical remission but incomplete laboratory) in 7 patients--41.18 per cent, one patient with no change--5.88 per cent. Two patients--11.76 per cent, died of the complications of the treatment. Grave complications resulting from the treatment were obtained in seven patients.

Acenocoumarol↗
PubMed1981

[Current trends in the treatment of chronic glomerulonephritis].

The results from the long-term combined anticoagulant, immunesuppressive and corticosteroid treatment of 36 patients with various histological forms of idiopathic and lupus glomerulonephritis are reported. Twenty five of them are with preserved or slightly disturbed renal function, and 11 - with chronic renal insufficiency. The treatment was carried out with heparin, acenocoumarol, azathioprin and to the patients with lupus glomerulonephritis - corticosteroids in the course of 4 to 50 months. The results were "very good", "good", with "no change" and "deterioration" according to clinical and laboratory indices. Very good and good effect was obtained in 18 patients (72%) of the group with preserved or slightly disturbed renal function (25 patients). Five patients were with no change (20%) and 2 patients died of complications in connection with corticosteroid treatment. Very good results was obtained in 2 patients with rapid progressive glomerulonephritis from the group with chronic renal insufficiency (11 patients) and the rest were without effect. The adverse effects are not frequent and are mainly due to corticosteroids. The combined anticoagulant and immunosuppressive treatment is concluded to be indicated in patients, with idiopathic and lupus nephritis with preserved or slightly disturbed renal function, in patients with rapidly-progressive glomerulonephritis but not in case of manifested chronic renal insufficiency. The considerable duration and the systematic follow-up control are of essential importance for the treatment success.

Adolescent↗
PubMed1980

[Severe posttransplant lung syndrome and an acute transplanted kidney rejected crisis successfully controlled].

After a brief literature survey of the immune complications after kidney transplantation, the authors report one patient with a severe febrile-intoxication and pulmonary dyspneic syndrome with abundant X-ray findings, consisting of large nodular and diffuse striped densities, moderately dense, reminding disseminated or miliary tuberculosis, or pneumonia in case of pneumocystis carini, on the background of poor physical findings and normal pCO2. The pulmonary changes disappeared after a treatment with high doses of glucocorticoids -- 6.750 mg predniso, imuran -- 3 mg/kg body weight and a combination of ampicillin, seporacin and nystatin -- for a total of 25 days. In parallel with the pulmonary syndrome an acute crisis followed for the elimination of the transplantant, which after the control of the pulmonary syndrome became particularly intense, blood urea reaching 150 mg% and creatinine -- 5.6 mg%. The crisis was inhibited by high prednison doses according to the scheme adopted at the Neccer hospital in Paris. The patient was discharged with 65 mg% urea and 1.5 mg% creatinine. The patient followed up for 10 months, continued to improve. Interesting data were obtained from the kidney during the crisis for elimination via a dynamic ventricular scintigraphy, differentiating the mechanical obstacle for urine elimination from the prolonged intrarenal transport of radioactive pharmaceutical, being characteristic for the crisis of elimination.

Acute Disease↗
PubMed1976

Diagnostic value of ceruloplasmin, haptoglobin and sialic acid in chronic pyelonephritis.

In a group of 84 patients with exacerbated chronic pyelonephritis the authors have determined the blood serum levels of ceruloplasmin, haptoglobin and sialic acid before, during and after antibacterial treatment. They have found a decrease in these levels following treatment. The results of ceruloplasmin, haptoglobin and sialic acid assays could be used as an index for the activity of the pathologic process, as well as in the differential diagnosis between pyelonephritis and glomerulonephritis.

Ceruloplasmin↗