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Biomedical subjects

I Gordon

Publications and source records attributed to I Gordon.

At least 271 records · Page 15Linked to original sources
PubMed1976

Extragastric gastrinoma or G-cell hyperplasia of the antrum? The preoperative diagnosis in a case of hypergastrinaemia.

A patient is described with recurrent peptic ulceration, evidence of hypersecretion of gastric acid and excess circulating gastrin. The preoperative differentiation between extragastric "gastrinoma" and G-cell hyperplasia of the pyloric antrum as a source for the hypergastrinaemia can be made by immunofluorescent staining of an antral biopsy for "gastrin cells", and by measuring the response of the gastric antrum to an amino acid meal or secretion infusion stimulus. The site of excessive gastrin production determines the nature of the surgery required. A classification of recurrent peptic ulceration types is suggested.

Amino Acids↗
PubMed1976

Recruitment and plasmapheresis of donors to provide human antitetanus immunoglobulin.

A method is described whereby about 100 litres of plasma containing 10-50 IU/ml tetanus antitixin was obtained, from which were prepared 5000 X 250 IU doses of human antitetanus immunoglobulin. Of 40 blood donors who received a booster injection of tetanus vaccine BP, 33 were plasmapheresed each week over a 10-12 week period starting three weeks after the injection. Twenty-two of these donors provided 90% of the total plasma, the antitoxin content of which averaged 23.6 IU/ml over the 10-12 week period.

Blood Donors↗
PubMed1976

Similarities of two hepatitis A virus strains.

In outbreaks of type A hepatitis in Los Angeles, USA, and Rosario, Argentina, virus particles were isolated from faeces. The geographically diverse strains were identical in appearance and serological reactivity. They differed only in buoyant density, but other workers have also obtained inconsistent results in estimating this. We conclude that the virus strains in the two epidemics were identical.

Hepatovirus↗
PubMed1975

The medicolegal aspects of rapid deaths initiated by hypoxia and anoxia.

In all forms of death the postmortem findings may be divided into two groups. The first group comprises those of general pathologic changes, such as visceral congestion and petechial hemorrhages. These nonspecific changes are always present in a greater or lesser degree in rapid deaths initiated by hypoxia and anoxia as well as in deaths from shock and natural causes. The second group consists of the pathologic changes which are dependent upon the type of death, eg, the local injuries to the neck in throttling and strangulation, and the color of the blood in acute carbon monoxide poisoning. Such changes are best described as special pathologic changes. In the description of postmortem findings for medicolegal purposes, a clear distinction should be drawn between nonspecific general pathologic changes and special pathologic changes which are dependent upon the type of death. All postmortem findings should be considered under the two headings: (1) special pathologic changes; and (2) nonspecific general pathologic changes.

Animals↗
PubMed1974

Antiviral activity of 3-methyleneoxindole.

3-Methyleneoxindole (MO), an oxidation product of the plant auxin indole-3-acetic acid, can selectively inhibit the replication of herpes-, mengo-, polioviruses, and Sindbis virus. The antiviral action of MO, a sulfhydryl binding compound, is neutralized by 2-mercaptoethanol if the latter is added soon after exposure of infected cells to MO. If addition of 2-mercaptoethanol is delayed, the antiviral action of MO appears to be irreversible. Data are presented which indicate that the antiviral action of MO is not mediated by interferon.

Animals↗