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Biomedical subjects

I Gery

Publications and source records attributed to I Gery.

198 records · Page 11Linked to original sources
PubMed1966

Role of the thymus in tolerance. 3. Tolerance to bovine gamma globulin after direct injection of antigen into the shielded thymus of irradiated rats.

Rats subjected to high doses of whole-body irradiation, with simultaneous shielding of the thymus or spleen, recovered at 3 wk the ability to develop delayed sensitization and to form hemagglutinating and precipitating antibody following foot-pad injection of BgammaG in complete adjuvant. Injection of BgammaG into the shielded thymus immediately after irradiation, in amounts between 20 gammag and 40 mg, inhibited these response to later challenge partially or completely. A comparable effect on immune responses to BgammaG was not seen after injection of heterologous antigen (Ea) intrathymically, BgammaG intraperitoneally, or BgammaG into the shielded spleen. However high doses (20 or 40 mg) of antigen given by the latter routes resulted in some diminution of later response. Arthus reactivity recovered partially in the spleen-shielded group and was readily suppressed by intrasplenic administration of antigen.

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PubMedDate not supplied

Serum proteins neutralize the toxic effect of lysophosphatidyl choline.

Lysophosphatidyl choline (LPC), which has been shown to be toxic to the lens in organ culture, is markedly elevated in uveitic eyes. These findings have led to the suggestion that LPC is an initiator of cataractogenesis in uveitis. We report here that a factor not considered by previous investigators, i.e. the presence of serum proteins, can modulate LPC toxicity in vitro. First, the toxicity of LPC to lens epithelial cells or to whole lens in organ culture was effectively neutralized by addition of serum or serum albumin to the test cultures, thus suggesting that the potential toxicity of the increased LPC in the uveitic eye might be neutralized by the concomitant increase in serum protein. Secondly, the susceptibility to LPC toxicity of lens epithelial cells was no greater than that of lymphocytes which are normally exposed to LPC levels higher than those in the uveitic eye.

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