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Biomedical subjects

I Gergely

Publications and source records attributed to I Gergely.

31 records · Page 2Linked to original sources
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Changes in thyroid hormones and serum lipids of aged women following thyroidectomy.

Thyrotropin (TSH), thyroxine (T24) 3,5,3403 triiodothyronine (T23), serum lipid levels and ECG findings in females who underwent thyroidectomy 2-44 years earlier, were compared to those of similar controls with intact thyroid. Pathological ECG is more frequent in thyroidectomized persons who also exhibit higher thyrotropin and lower HDL-cholesterol levels. The results indicate that thyroidectomized state should be regarded and controlled as a possible condition of subclinical hypothyreosis, being a risk factor of cardiovascular diseases.

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The effect of smoking on peripheral blood lymphocytes and on some immunological parameters in old age.

To investigate the influence of smoking on the aging immune system, the following parameters were determined in elderly smokers and non-smokers: presence of emphysema; absolute number of leucocytes, lymphocytes, T cells and B cells bearing membrane-bound IgG; serum IgG, IgA, IgM levels, occurrence of rheumatoid and antinuclear factors, and natural antibody level (against different bacteria). Ultrastructural disorders in lymphocytes were also investigated. The number of leucocytes, the levels of serum IgA, and the prevalence of autoantibodies were higher, and the natural antibody level was lower in smokers than in non-smokers. Giant mitochondria and cytoplasmic disorders were found more frequently in smokers than in non-smokers, and in an even higher rate in smokers with emphysema. These findings suggest that smoking may accelerate the appearance of age-dependent (especially disease-related) immunological changes.

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The effect of family background on body weight and on the number and morphological changes of lymphocytes in old age.

The authors examined elderly people (214 males and 304 females) 60 years of age and over, without overt diseases. They studied the relationship between family background and body mass index as well as quantitative changes in circulating lymphocytes as a function of the above parameters. The average age of the examined men was 74 years, 86% of them lived with their families; the average age of the women was 72 years and 51% of them lived with their families. A mathematical analysis of the body weight measurements showed that the drawn sample readily follows a normal distribution. It was also shown with respect to the examined persons that body weight, body height, and body mass index decrease with age and differ with sex. In overweight persons degenerative changes in the mitochondria of the peripheral lymphocytes were more frequent than in persons of normal weight.

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Gender differences in age-related physiological changes and some diseases.

The clinical and laboratory data from a cross-sectional and a longitudinal study of healthy individuals between 50-89 years of age and that of centenarians were compared. The examination showed that in healthy elderly subjects and centenarians most of the clinical laboratory findings were in the normal range. However, age-related changes could be observed in erythrocyte sedimentation rate, in serum albumin level, and in the frequency of rheuma factor. Gender difference could be seen in the HDL-cholesterol level. Age and sex differences were observed in the hematocrit-, and hemoglobin-values, in serum creatinine-, total cholesterol-, serum IgG, IgA, IgM-levels, and in the frequency of the occurrence of antinuclear factor. The examinations demonstrated that lower hemoglobin and hematocrit values, elevated total-cholesterol level, the presence of antinuclear and rheuma factor, and elevated systolic blood pressure were more frequent in females than in males. It could be stated, however, that the mentioned changes did not prevent females from having a longer life span than males.

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