Biomedical subjects
Publications and source records attributed to I Gay.
Congenital laryngeal web, congenital heart disease, and low stature occurred in a 23-year-old woman. The patient was a member of a family in which several members were similarly affected. This triad of congenital anomalies is a syndrome that has not been previously reported. The pattern of inheritance of this syndrome is compatible with an autosomal dominant gene.
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A case of clinically unsuspected pneumoparotitis diagnosed by CT is presented. The CT demonstration of air collections in the parotid gland and in the parotid ducts until their buccal orifices, as well as in the adjacent high-pressure buccal air pockets, determines the diagnosis.
A rare case of chondrosarcoma at the skull base is presented. Computerized tomography scan was very helpful in delineating the exact extent of the tumor. Chondrosarcoma is a slow growing malignant tumor which metastasizes very late. Usually it is radioresistant, but when surgery is not feasible, irradiation treatment is worth a trial.
Maxillary sinus lavage through the canine fossa was performed on 202 patients. This procedure is relatively safe, easily learned and quickly performed, has minimal side effects and a very low percentage of failures, and is more acceptable to most patients. It should be used by otolaryngologists, at least as a useful alternative to the classical method.
Short latency vestibular evoked response to repetitive acceleration stimuli were recorded by skin electrodes in cats, using electronic filtering and averaging techniques. The evoked response is composed of six to eight waves during the first 10 ms after the stimulus. These are followed by longer latency responses which are myogenic in nature. All of these waves disappear with the animal's death and after excision of both eighth nerves. In recordings from the animal after excision of the eighth nerve on one side, the response patterns of excitation versus inhibition are demonstrated using excitatory and inhibitory acceleration stimuli. The possible generators of the evoked response are discussed in the light of the physiology of the vestibular pathways.
The detection of markers associated with malignancy will help in the early identification of tumors and assessment of the success of treatment in patients suffering from carcinoma. Three characteristics investigated in this study were found to differentiate a premalignant inverted papilloma from a benign simple nasal polyp.
A case of diffuse idiopathic skeletal hyperostosis (Forestier's disease) causing dysphonia as the presenting and only symptom is reported. The dysphonia is attributed to the mass effect in the hypopharynx and the mild pressure on the larynx. The bony mass anterior to the vertebral body is demonstrated by CT scan for the first time in the literature on Forestier's disease.
BACKGROUND: Selective accumulation of boron-10 isotope in the nuclei of cancer cells is pivotal to the success of Boron Neutron Capture Therapy (BNCT). Sophisticated microanalytical techniques are needed for checking the selectivity and boron delivery characteristics of experimental BNCT drugs. The present study employs a secondary ion mass spectrometry (SIMS) based subcellular isotopic imaging technique of ion microscopy for testing four carboranyl nucleosides. MATERIALS AND METHODS: CDU, HMCDU, CTU, and CFAU were tested for their boron delivery to the nuclear and cytoplasmic compartments of U251 human and F98 rat glioma cells. Quantitative SIMS analysis of boron was carried out in cryogenically prepared cells. RESULTS: For all drugs, the cell cytoplasm revealed significantly higher boron than the nucleus. However, the boron partitioning between the cell nucleus and the nutrient medium indicated 6.4-10.6 times higher boron in the nucleus. CONCLUSION: Carboranyl nucleosides studied here may provide efficient BNCT agents and need further evaluations of their efficacy.
A study to evaluate late potentials (LP) was carried out in 50 patients diagnosed as suffering from coronary heart disease. All the patients were divided into two groups: Group A, was made of 25 patients in the acute period of myocardial infarction, and group B, was made of other 25 patients in the chronic phase, with more of 3 months of evolution from the acute event. Average age in group A was 54.2 years, and 58.1 years in group B. Twenty normal volunteer subjects (group C) were also studied as a reference group. All the subjects in the 3 groups were in normal sinus rhythm, and no one of them showed bundle branch block in the basal ECG. Analysis of the vector magnitude was made for each point of the averaged wave, as the result of the mean root square of the addition of bipolar leads X, Y and Z, using a LP-3000 Fidelity Medical Inc. equipment, with a four poles Butterworth filter. LP were detected in 32% of the patients in group A, and in 56% of the group B (p less than 0.001). No LP was observed in patients of the group C. Concerning the localization of myocardial infarction, maximum CPK value, or Lown's grade of ventricular arrhythmias observed in coronary care unit, or in the 3rd week Holter monitoring, did not show significant statistical correlationship with the presence of LP in group A.(ABSTRACT TRUNCATED AT 250 WORDS)