Search PubMed⌕ Search

Biomedical subjects

I G Cleator

Publications and source records attributed to I G Cleator.

31 records · Page 2Linked to original sources
PubMed1970

Bio-assay evidence of abnormal secretin-like and gastrin-like activity in tumour and blood in cases of "choleraic diarrhoea".

Methods for bio-assay of secretin-like humoral agents in both cat and dog are described. Bio-assay of tumour extracts and of plasma from patients with the pancreatic choleraic syndrome are described. The first patient was found to have choleretic and secretinlike activity in an extract of her pancreatic islet cell tumour and gastrin-like activity in her plasma. The second patient was found to have both secretin and gastrin-like activity in her plasma, as well as choleretic activity. It is concluded that at least part of the profuse, watery electrolyte diarrhoea of the ;pancreatic cholera' syndrome associated with peptide-secreting adenoma of the pancreas is likely to be a reflection of the excessive production of secretin, as well as of gastrin, and possibly also of a choleretic agent.

Adenoma, Islet Cell↗
PubMed1970

Experiences with a rat bio-assay in the diagnosis of the Zollinger-Ellison syndrome.

Reported here are the assay results, using the anaesthetized rat preparation of Lai (1964), of plasma from patients known or suspected to have peptide-secreting adenomata and these are compared with assays carried out on plasma from patients whose clinical history excluded such pathology. It is suggested that these demonstrate that this technique is of diagnostic value in this condition and that it has practical advantages over other bio-assay methods currently available and physiological advantages over immunological methods. It may well be that identification of the presence of tumour in these patients may first be made by immunological techniques to be followed by functional identification using a bioassay procedure such as is described here.

Animals↗
PubMedDate not supplied

Glucose handling in morbid obesity and the effects of surgically induced weight loss.

Morbid obesity is associated with glucose intolerance. We studied the rate of glucose turnover in 18 morbidly obese individuals and compared the results to 10 normal weight controls using the technique of the hyperglycemic clamp. Rate of glucose turnover (mg/kg/min) was defined as metabolic clearance of glucose and corresponding plasma immunoreactive insulin values were determined. The ratio of metabolic clearance of glucose to plasma insulin is a reflection of endogenous insulin sensitivity. Patients were studied again 3 months following jejunoileal bypass and gastroplasty. Fasting glucose was similar for all groups. Fasting immunoreactive insulin was 16.8 +/- 5 microU/ml in preoperative obese, 4.3 +/- 0.2 in controls, 6.8 +/- 0.6 in postoperative jejunoileal bypass, and 6.2 +/- 0.3 in postoperative gastroplasty. The difference between postoperative groups was not significant at 3 months. The jejunoileal bypass group at 1 yr gave similar results to the immediate postoperative findings. In normals the value of metabolic clearance of glucose was 3.9 +/- 0.7 mg/kg/min and in the obese it was 2.05 +/- 0.2 (p less than 0.05). No significant improvement occurred postoperatively. Mean of the immunoreactive insulin values from 60 to 120 min was greater in preoperative obese than controls, 44.0 compared to 13.6 microU/ml (p less than 0.05). A highly significant postoperative lowering occurred in both groups, jejunoileal bypass 20.7 microU/ml, gastroplasty 22.4 microU/ml, but the difference between the surgical groups (jejunoileal and gastroplasty) is not significant. The ratio of metabolic glucose clearance to plasma insulin followed a similar pattern the primarily to the substantial decrease in insulin levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗