Search PubMed⌕ Search

Biomedical subjects

I Furuta

Publications and source records attributed to I Furuta.

At least 73 records · Page 4Linked to original sources
PubMed1993

[Intestinal flora of inpatients and isolation frequency of methicillin-resistant Staphylococcus aureus].

The authors compared intestinal flora from 30 healthy volunteers and 128 inpatients. E. coli, B. fragilis, and Bifidobacterium were each detected in the stools of healthy subjects at a frequency of more than 90%, while the incidences of such flora were low in the stools of inpatients: A significant difference was observed between the two groups. E. faecium, P. aeruginosa, Methicillin-resistant Staphylococcus aureus (MRSA), C. difficile, and Candida were detected at high frequencies in the stools of inpatients, as compared with healthy subjects. This finding is attributed to the administration of antimicrobial agents. It is also considered that microbial interaction in maintaining the balance among normal intestinal flora had been lost in patients from whom MRSA and/or C. difficile was isolated. The decrease or elimination of bacterial species antagonistic to such resistant strains must be guarded against, because this can lead to weakening of the defence mechanism against intestinal infection.

Enterococcus faecium↗
PubMed1991

[An autopsy case of neoplastic angioendotheliosis mainly affecting the lung and presenting with atypical cells in peripheral blood].

Neoplastic angioendotheliosis (NAE) is a rare condition characterized by proliferation of atypical cells in small vessels of various organs. In the past, atypical cells seen in this condition were considered to originate from vascular endothelial cells. However, recent immunohistochemical studies have established that the tumor cells in this condition mainly originate from B-lymphocytes. NAE is likely to affect the central nervous system and skin. Cases of NAE with a primary lesion in the pulmonary vessels are rare. One such rare case of NAE was recently encountered by us. The patient was a 77-year-old woman who was admitted to our department because of fever and interstitial shadow in both lungs. After admission, fever did not subside, and the pulmonary shadow became more marked. Laboratory tests upon admission disclosed elevated LDH. Of isozymes, LDH2 and LDH3 were high. Anemia and thrombocytopenia gradually became aggravated, and atypical cells with large basophilic cell body and irregularly shaped nucleus subsequently appeared in peripheral blood. Thereafter, the patient's general condition worsened rapidly and she died about 5 months after admission. Post-mortem examination revealed pleomorphic atypical cells filling the lumen of small vessels in various regions of the body. This finding was particularly marked in pulmonary vessels. With various immunohistochemical stains, these cells were identified as cells of B-lymphocyte origin.

Aged↗
PubMed1991

[Humoral immunity and lymphocyte subsets in patients with dilated cardiomyopathy].

We examined immunological abnormalities in patients with dilated cardiomyopathy (DCM) and reviewed their medical histories, NYHA classifications, electrocardiogram findings and chest X-Ray findings with regard to severity of DCM. Elevated CD4/CD8 ratio as well as decreased number of CD8 cells in lymphocyte subsets was recognized. These abnormalities were particularly noted in patients with past history of myocarditis. NYHA IV class increases in CTR and left ventricular dimension, and a reduced ejection fraction. These findings suggest that lasting of myocardial damage causes immunological abnormalities and the examination of DCM patients' immunological status is useful in anticipating disease process and determining medical treatment.

Autoantibodies↗
PubMed1990

A case of chronic myelocytic leukemia in blast crisis: the myeloblasts became overt from lymphoid and myeloid mixed population of the blast crisis cells after chemotherapy.

Immunophenotypes and genotypes were analyzed for a case of chronic myelocytic leukemia in blast crisis (BC). In the early stage of BC (early BC), the blasts consisted of lymphoid-myeloid cells, but in the later stage of BC (late BC), they were myeloid cells, morphologically and phenotypically. On Southern blot of DNAs in early BC, a single rearranged fragment of immunoglobulin heavy chain (IgH) genes was detected, whereas IgH genes were in germline configuration in both initial chronic phase and late BC. A clone which had a rearranged IgH gene in early BC, was considered to have co-existed with a clone which had the germline IgH gene. Analysis for bcr genes confirmed that the chronic phase as well as early and late BC were of the same clonal origin. Phenotypic and immunogenotypic analyses, however, revealed that at least two secondary clones emerged from the primary clone. The therapeutic effect against lymphoid population among mixed crisis cells could be evuluated not only phenotypically but also genotypically.

Adult↗
PubMed1989

Intensive chemotherapy followed by autologous bone marrow transplantation for a patient having wide-spread embryonal carcinoma in the central nervous system.

A patient with an intracranial embryonal carcinoma, which was resistant to cisplatin-based combined chemotherapy and radiotherapy, developed spinal seeding. Alpha fetoprotein (AFP), human chorionic gonadotropin (HCG) and the beta chain of HCG (NCG beta) in serum or cerebrospinal fluid immediately returned to elevated levels despite sequential chemotherapy and resection. Accordingly, we treated this patient with spinal irradiation and intensive combination chemotherapy (cisplatin etoposide, vinblastine, cyclophosphamide and actinomycin D) followed by autologous bone marrow transplantation. With this treatment, the clinical manifestations showed a tendency to improve and, furthermore, the serum levels of AFP and HCG returned to normal. These findings suggest autologous bone marrow transplantation to be a potential approach to the treatment of patients with embryonal carcinomas.

Adult↗
PubMed1989

[Bacterial infection and rapid laboratory microbial methods].

The key to treatment of bacterial infectious diseases is always to quickly identify the causative organism and understand its resistance to drugs. Recent progress in microbial laboratory methods has permitted rapid detection and identification of pathogenic organisms. Rapid test methods are classified into culture and non-culture methods. Non-culture methods are based mainly on immunoassay for detection of antigen or antibody of pathogenic organisms, but also include the DNA probe method and the RNA probe method. Immunoassay is achieved by fluorescent antibody techniques, agglutination and ELISA. On a related note, monoclonal antibodies have been developed with steady progress. For culture methods, commercial bacterial identification kits and automated instruments, all of which permit quicker identification than with conventional methods, are now used in a large number of laboratories. Quick identification with these automated instruments is possible owing to optical determination of drug resistance. Some automated instruments are capable of rapidly detecting bacteria in the sample. For example, Bactec, used for quick diagnosis of bacteremia, measures CO2 produced by bacteria in the culture bottle during the metabolic process, permitting early detection of bacterial proliferation. Other methods are available in which ATP produced by bacteria is measured on the basis of bioluminescence or chemiluminescence.

Bacteria↗
PubMed1988

[Cytophotometric analysis of the nuclear DNA content in oral squamous cell carcinoma--relation between nuclear DNA content and clinico-pathologic findings].

Cytophotometric analysis has been performed on Feulgen-stained nuclei in smears taken from 48 biopsy specimens of squamous cell carcinoma of the oral cavity. The results were correlated with the clinico-pathologic findings of the tumor. DNA histograms were graded into three patterns: P-I (2C-2C), P-II (2C-6C) and P-III (2C-beyond 6C). DNA patterns of the carcinoma of the clinical stage I, II tended to be P-I, II and those of stage III, IV were mostly P-II, III. DNA patterns of carcinomas which were well differentiated and poorly pleomorphic with a few number of mitoses, were mostly P-I, whereas those which were poorly differentiated and remarkably pleomorphic with a many number of mitoses were mostly P-III.

Carcinoma, Squamous Cell↗
PubMed1987

[Single-agent trial with epirubicin in hematological malignancies].

Twelve patients with hematological malignancies were treated with epirubicin and ten patients were evaluable. One out of our four patients with ALL, who had a previous therapy of anthracycline, achieved a partial remission (PR: 25%). In two patients with AML, remission was not obtained. Of four patients with NHL, one with B-cell lymphoma achieved complete remission (CR) and one with ATLL partial remission (CR + PR: 50%). Stomatitis was observed as a major side effect in three patients with acute leukemia and in one with NHL. In conclusion, our trial seems to show the efficacy of epirubicin in lymphoid malignancies.

Acute Disease↗
PubMed1984

Electrical burns of lip and mouth in children. Report of 2 cases.

2 cases of electrical burns of the oral cavity in young children are reported. Both cases were treated conservatively. 1 of the patients, now that 3 years have passed, has a slight scar with a slight deformity of lower and upper lips. We are planning reconstructive surgery within a short time. There are no functional or developmental disturbances. The main cause of electrical burns in young children is biting or sucking the free end of live extension cords or placing sockets into the mouth. Since most of these injuries are from low-voltage, electric circuits are localized to the surroundings of the mouth. However, the injuries are small or narrow, but reach much deeper than initially appear. Therefore, the scar may be small but the deeper tissue may sustain more extensive damage than expected.

Burns, Electric↗
PubMed1984

Antigenic analysis of flaviviruses with monoclonal antibodies against Negishi virus.

Twelve monoclonal antibodies against Negishi virus were obtained and characterized by hemagglutination inhibition (HI) and neutralization (NT) tests using five flaviviruses isolated in the pan-Pacific region. The reaction pattern of the antibodies showed that Negishi virus was most closely related to Langat virus, followed by 3-Arch, JE and Apoi viruses in that order. Hemagglutinating (HA) antigen of the virus had distinct HI relating sites which were Negishi virus specific, tick borne encephalitis (TBE) virus complex specific and flavivirus cross-reactive. Monoclonal anti-Negishi antibodies cross-reactive to Japanese encephalitis (JE) virus in the HI test had neutralizing activity to JE virus but no activity to homologous Negishi virus.

Animals↗