The technique of obtaining pancreatic segments was studied in 60 mongrel dogs by removing the right pancreatic lobe. At the same time comparative surgical-anatomical examinations were performed for the detection of the vascular variations of the right pancreatic segment. In 83% of the cases the arterious and venous systems were suitable for gaining grafts (Types I-II). In 12% the segment was suitable for grafting only if the venous network had an optimal course (Type III), while in 5% the segment was unsuitable because it did not have a suturable arterial stump (Type IV).

Animals↗

PubMedDate not supplied

Effect of experimental airway inflammation on bronchial hyper-responsiveness induced by Broncho-Vaxom in dogs.

We studied correlation between airway hyper-responsiveness induced by local exposure to a macrophage inductor Broncho-Vaxom and the development of airway inflammation in dogs. To detect airway inflammation, bronchoalveolar lavage and biopsy of airway mucosa were performed. The airway responsiveness was registered by capnograph measuring gas-exchange disturbances during obstructive reactions provocated by inhalation of various concentrations of acetylcholine aerosol. Broncho-Vaxom generated a protracted airway inflammation characterized by a slight and reversible increase in the number of neutrophils at 24 h after induction, and by a long-lasting influx of macrophages peaked about at the second week. The number of macrophages turned to initial levels 3 weeks later. Macrophages migrating to the bronchoalveolar surface were activated because peroxidase positivity and bearing C3b receptors of these cells increased gradually during the inflammatory process. Airway responsiveness measured at 3, 6 and 24 h after induction did not differ significantly from baseline values, but hyper-responsiveness was developed at 96 h using 0.5 and 1.0% acetylcholine aerosol (p less than 0.01 and p less than 0.001) during the non-purulent, macrophage-mediated inflammation. This situation modelled by Broncho-Vaxom induction is very similar to those observed in children with recurrent obstructive bronchitis. The results suggest that a macrophage-mediated inflammation caused by antigens, infections or pollutants may generate a long-lasting airway hyper-responsiveness.

Acetylcholine↗

PubMedDate not supplied

Stenosing effect of vessel sutures: experimental studies.

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Arteries↗

PubMedDate not supplied

Protecting effects of intravenous insoluble glycogen treatment on the experimental necrotizing acute pancreatitis of dogs.

BACKGROUND/AIMS: We have studied the effects of insoluble glycogen applied intravenously on the experimental acute pancreatitis of dogs. METHODS: Experimental acute pancreatitis was induced by olive oil injected into the main pancreatic duct. The effects of insoluble glycogen were evaluated histologically and by measurements of levels of amylase, lipase in sera. The binding of endotoxin and secretable phospholipase A2 by insoluble glycogen were tested by isotopically labeled materials. RESULTS: Application of insoluble glycogen had beneficial effects on the experimental acute pancreatitis of dogs. CONCLUSION: The binding capacity on endotoxin and secretable phospholipase A2 could play the main role in the protection offered by insoluble glycogen.

Amylases↗