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Biomedical subjects

I Furka

Publications and source records attributed to I Furka.

At least 19 recordsLinked to original sources

Experimental study of parenteral nutrition and of the exocrine function of the pancreas.

The effect of parenteral nutrition on the pancreatic secretion was studied under experimental conditions. Experiments were carried out in 24 mongrel dogs. In all animals pancreatic fistulas were created for collection of pancreatic juice. Subsequently, in three groups (6 dogs in each) parenteral nutrition via a catheter enterostomy was applied in three different segments of their small bowels, while collecting the pancreatic juice. Group IV served as control where no parenteral nutriment was administered. The amount, pH, protein and enzyme levels of the pancreatic juice secreted during 4 hours were studied in all groups. The experiments revealed that parenteral nutrition at the initial segment of the jejunum enhanced pancreatic secretion, while this was not experienced in the other groups. The effect is assumed to be humoral, rather with a secretin-like stimulation. Based on the experimental results, the authors call attention to the fact that, during treatment of acute pancreatitis, if a feeding enterostomy is constructed for calorie intake, it should not be performed within the first metre of the jejunum.

Animals

Experience obtained during liver resections made under experimental conditions by a telescopic compressor (AKE).

Liver resection experiments in dogs made by the AKE telescope compressor are reviewed. It is established that the instrument can be applied to the liver parenchyma of varying size and compressibility. The time of resection is short and the intervention entails only minimal loss of blood. Using this solution, it is not necessary to produce the transitory warm ischaemia of the liver.

Animals

Partial splenectomy performed by a special technique in dogs.

Closure of the splenic surface is solved at splenectomy by placing a raw of sutures using a double thread inserted at the same level by two straight needles. This technique does not require interpositions with a good haemostasis and so favours wound healing. It does not need many instruments and is easy to perform.

Animals

[Heterotopic autotransplantation of the spleen in animal experiments].

A new technique of heterotopic autotransplantation of pieces of the spleen is suggested. It differs from the methods used previously in that the pieces of the autologous transplant are placed between the layers of the greater omentum and not on its surface. Not only was the viability of the pieces of the autologous transplant maintained but the hazard of intraabdominal adhesions and their unfavourable consequences was reduced to a great measure.

Animals

Experimental study of autologous free omental grafts.

The fate of intraabdominal free omental grafts was studied in 15 dogs and it was found that a connection between the hollow organ and the transplanted omentum was established only when the former had been injured. The larger, pigeon-egg-sized free fatty omental grafts became necrotic already from the fourth day onwards being replaced by an abscess-like structure, while in thin membrane-like grafts tissue necrosis due to the creeping in of connective tissue was less marked. In both cases, an intact, omentum is creeping over the graft from the adjacent region, i.e. the ultimate covering is actually provided by the pedicle graft.

Animals

Data on renal hypothermia by the venous passage.

The temperature values obtained in renal hypothermia through the venous circulation were biometrically analysed. It was found that there could be even about 4 degrees C temperature differences between the lower and upper poles of the kidney, always as large as 4 degrees C could be elicited in the first five minutes of hypothermia, the lower pole being colder. Similar but smaller differences were observed in ten minutes' hypothermia.

Animals

Combined use of bioplast and tissue adhesive in experimental nephrectomies in in situ renal hypothermia.

In transvenous regional hypothermia wedge-shaped and flat lower pole resections were made in dogs. The cut surface of the kidney was covered by the combination of tissue adhesive and bioplast without sutures. It was found that the polymerization time of the tissue adhesive almost doubled. The usual rigidity of the adhesive was more expressed than in normothermia and it was not influenced by re-heating. Recovery conditions were more favourable; a larger portion of the parenchyma could be preserved than with the traditional closure with needle and thread.

Animals

Experimental in situ renal hypothermia through the renal vein.

The authors worked out the technique of in situ renal hypothermia in dogs by direct cannulation of the renal vein or through the internal spermatic vein (ovarian vein). The technique is suggested for preventing the ischaemic impairment of the renal parenchyma in operations requiring compression of the renal artery for more than 20 minutes.

Animals

Experimental study of suture materials placed in the renal parenchyma.

Absorbable and non-absorbable suture materials in the renal parenchyma were examined in comparative studies performed on 12 mongrel dogs. Quantitative and qualitative histological studies showed that Dexon was preferable to other absorbable suture materials as opposed to traditional catgut, while Supramide and Polyester had certain advantages over other non-absorbable materials.

Absorption

Sutures inserted into the gastric wall an experimental study.

Thirty gastrotomies were performed in 15 dogs using 2/0 atraumatic needles. Various kinds of threads were used: Dexon as an absorbable suture, Black Perlon and Black Braided Silk as nonabsorbable sutures. Ten suture rows were made with each material. Single-row interrupted sutures were made with no suture in the mucosa. No suture insufficiency occurred. Dexon proved to be the most suitable material, although the nonabsorbable sutures did not cause complications, either.

Animals

Comparative studies with extracorporeal hypothermal kidney perfusion.

Various solutions of extra- and intracellular, or non-electrolyte type supplemented with papaverine or lidocaine were administered by gravity perfusion to 60 dog kidneys. Cooling in the kidneys perfused with the solutions containing papaverine lowered the temperature of kidneys in significantly shorter time than in those containing lidocaine. The histological examinations revealed good perfusion with solutions containing papaverine; even the rim of the cortical substance has been freed of blood. Identical results could not be achieved with lidocaine. These results are to be considered in the clinical work.

Animals

[Securing anastomosis of the large intestine with glued autologous tissue].

The colon was cut through across in 32 dogs without essential preparation. The recombination of the ends was carried out by a single-row stitched suture. This one was covered with an autologous strip of parietal peritoneum and fascia which was stuck by histoacryl-N-blue. The results were good after practising this technique.

Animals

Experimental partial splenectomy.

Partial splenectomy was performed on 25 dogs, removing the lower third of the spleen by a transverse incision. Stronger bleeding was ligated while parenchymatous haemorrhage was covered with Gelaspon plus Topostasin or Surgicel. The substances were sutured to the spleen with Dexon suture. Both substances proved advantageous, but the application of Gelaspon induces less tissue reaction and results in thinner neocapsule.

Animals

Tissue reaction to Histoacryl Blue adhesive and histological investigation of its disappearance in various organs.

The effect of the adhesive Histoacryl Blue on the abdominal organs (liver, stomach, intestines, colon, kidneys, bladder, aorta inferior vena cava and skin wounds) of 15 dogs was investigated histologically. The adhesive was applied in thin or thick layers in various ways: applied on intact or injured surfaces, or introduced into the parenchymal organs. The animals were killed 1, 2, 4, 8 weeks and 3 and 6 months after application of the adhesive and the organs containing Histoacryl Blue were processed histologically. The success of adhesion depended, irrespective of the organ, upon the technique of application and on the quantity of the adhesive used.

Animals