Biomedical subjects

I Friedrich

Publications and source records attributed to I Friedrich.

At least 37 records · Page 2Linked to original sources

PubMed1999

Treatment of carotid artery stenosis by elective stent placement instead of carotid endarterectomy in patients with severe coronary artery disease.

Patients with concomitant cardiac and cerebrovascular disease undergoing revascularization procedures are at high risk of both, cardiac and cerebrovascular complications. The purpose of our study was to evaluate the feasibility of prior elective carotid artery stenting as an alternative treatment procedure to carotid endarterectomy (CEA) in patients with concomitant coronary artery disease (CAD), who clearly needed coronary revascularization. We offered extracranial internal carotid stenting to 85 patients with 89 significant carotid stenoses. Out of these, 19 patients were symptomatic. The quantitative mean reduction in diameter was 77 +/- 11%. Stent implantation was successful in 88 lesions. Two disabling major and 3 reversible minor strokes occurred periprocedurally. Three patients showed asymptomatic restenosis and stent deformation was detected in 2 patients. Based on this experience, carotid stenting in high risk patients with severe coronary artery disease is feasible and safe and might be indicated as an alternative procedure for combined surgery.

Adult↗

PubMed1996

Clearance of postprandial lipoproteins in normolipemics: role of the apolipoprotein E phenotype.

The hepatic clearance of triglyceride-rich lipoproteins is mediated via apolipoprotein (apo) E which occurs in three common isoforms, apoE2, apoE3 and apoE4. To study the importance of the apoE isoforms on the response curves of different triglyceride-rich lipoproteins and the effect of chylomicron remnants on the composition of HDL, 37 normolipemics were investigated after a standardized fatty meal (8 apoE2/E2, 8 apoE2/E3, 8 apoE3/E3, 7 apoE3/E4 and 6 apoE4/E4). These individuals were matched for age, body mass index, fasting triglycerides, HDL-cholesterol, and apoA-I. A delayed chylomicron remnant clearance was observed only in apoE2 homozygotes, and this delay was neither correlated with fasting lip ds nor with peak lipoprotein concentrations. In apoE2/E3 heterozygotes, in contrast, the defective isoform E2 appears to be compensated for by the normal apoE isoform E3. In non-apo-E2/E2 individuals, the chylomicron remnant response was highly correlated with the magnitude of chylomicron and VLDL responses, with fasting triglycerides, and with the triglycerides enrichment and cholesterol depletion of HDL. These correlations were not observed in apoE2/E2. From these results we conclude that the chylomicron remnant response curve is an indicator of the extent of postprandial lipemia in non-apoE2/E2 individuals only.

Adult↗

PubMed1996

Exposing the circumflex coronary artery: the heartflip technique.

A method to expose the circumflex coronary artery in its course in the atrioventricular groove is introduced. No special equipment or assistance is required. This method also can be applied to expose the obtuse marginal branches of the circumflex coronary artery. Adverse effects have not been observed.

Cardiac Surgical Procedures↗

PubMed1994

Double-blind, randomised, multi-centre clinical study evaluating the efficacy and tolerability of nimesulide in comparison with etodalac in patients suffering from osteoarthritis of the knee.

In a double-blind study, the efficacy and tolerability of nimesulide 200mg/day, administered orally, was compared with etodolac 600mg/day in the treatment, for 3 months, of 200 patients suffering from osteoarthritis of the knee. Although spontaneous pain showed a significant improvement during the course of the study, there was no difference in the efficacy of either compound. Similarly, there was a progressive and significant reduction in the Lequesne functional index although no statistical difference was found between nimesulide and etodolac. The physician's overall assessment of efficacy was significantly in favour of nimesulide but the same assessment for patients who completed all 12 weeks showed no such bias. Adverse events (AEs) were generally mild or moderate and were commonly gastrointestinal in origin. There was no difference in the rate of incidence of AEs and, with the exception of week 8 where etodolac was apparently better tolerated, there were no statistical differences in tolerability between the two therapies.

Adult↗

PubMed1994

Results of mitral valve reconstruction in mitral valve insufficiency.

In the last three years forty mitral valve reconstruction (MR) procedures were performed in case of mitral insufficiency (MI). In three cases, anatomical changes made reconstruction impossible for us. One patient had to be re-operated because of unsatisfactory valve function. There was no operative mortality. In twelve of the patients, mitral insufficiency was the only problem, while in twenty eight others additional cardiac procedures (CABG, AVR) were performed. The patients' age ranged from 17 to 77 years. The aortic cross-clamping time for mitral reconstruction without additional cardiac procedures ranged from 35 to 134 minutes. With one exception, the post-operative TEE indicated no, or very little, insufficiency. We concluded that the mitral valve insufficiency can be corrected with very good results and with a very low rate of complications. Such corrections ought therefore be taken into consideration before valve replacement.

Adolescent↗

PubMed1992

The ability of Brucella melitensis to grow on Loewenstein-Jensen egg medium: presentation of a case with Brucella meningitis.

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Adolescent↗

PubMed1989

[Chronic subdural hematoma simulating transient ischemic attacks].

Chronic subdural hematoma presenting as transient ischemic attacks (TIA) is very rare. In a 74-year-old man in whom chronic subdural hematoma was responsible for recurrent attacks of local neurological deficiencies, the diagnosis was established by computerized tomographic (CT) scanning. Both TIA and chronic subdural hematoma usually occur in the elderly. Since the prognosis as well as the therapeutic approach are completely different in the 2 conditions, it is advisable to use imaging techniques, such as CT scanning, when there are recurrent TIA.

Aged↗

PubMed1988

[Research schools in pharmacy. 1. Theory and methods in research schools in pharmacy; 29. The history of pharmaceutical science].

Part 1: On the theory and the methodology of research schools Contributions on the History of pharmaceutical science, part 29. The paper is the first part of an extensive investigation about the development of research schools of pharmacy. The major purpose of this part is to give a definition of pharmaceutical research schools and a methodology for the historical study of research schools. In trying to postulate and analyse the most propitious conditions by which a research school could flourish in the time from the end of the 18th century to the end of the 20th century, we have clearly take into account aspects, chief elements, such as the director or teacher, the scientific programme the students, the research conditions and the public and social recognition. To this aspects is given a methodological-programme for the historical analysis.

Germany, East↗

PubMed1983

[Paroxysmal supraventricular tachycardia in the delivery room].

In case of tachycardia the whole clinical picture should be taken into consideration. After exclusion of other kinds of shock also in the delivery room it should be thought of the rare cardiogenic shock caused by paroxismal supraventricular tachycardia. Stimulation of nervus vagus and/or drugs have good success.

Adult↗

PubMed1982

Lymphocyte responsiveness per unit volume of blood in patients with chronic nonalcoholic and alcoholic liver disease. Plasma inhibitory factors and functional defects of responder cells.

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Chronic Disease↗

PubMed1979

[Causes of clavicular fracture in newborns (author's transl)].

Accumulation of clavicular fractures among newborns on the authors' ward is reported, with reference to 1978. Twenty clavicular fractures were recorded from 1.6 per cent of all newborns, in the above period under review. They were related to cephalic presentations and to the upper shoulder in 90 percent. They were closely correlated to high birth weight. Positioning of the women concerned and medical supervision of delivery seemed to be of causative importance.

Birth Injuries↗

PubMed1975