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Biomedical subjects

I Friedmann

Publications and source records attributed to I Friedmann.

At least 19 recordsLinked to original sources
PubMed1997

Expression of GTP-dependent and GTP-independent tissue-type transglutaminase in cytokine-treated rat brain astrocytes.

Tissue-type transglutaminases (TGases) were recently shown to exert dual enzymatic activities; they catalyze the posttranslational modification of proteins by transamidation, and they also act as guanosine triphosphatase (GTPase). Here we show that a tissue-type TGase is expressed in rat brain astrocytes in vitro, and is induced by the inflammation-associated cytokines interleukin-1beta and to a lesser extent by tumor necrosis factor-alpha. Induction is accompanied by overexpression and appearance of an additional shorter clone, which does not contain the long 3'-untranslated region and encodes for a novel TGase enzyme whose C terminus lacks a site that affects the enzyme's interaction with guanosine triphosphate (GTP). Expression of two clones revealed that the long form is inhibited noncompetitively by GTP, but the short form significantly less so. The different affinities for GTP may account for the difference in physiological function between these two enzymes.

Amino Acid Sequence↗
PubMed1996

Intestinal-type sinonasal adenocarcinoma: a sporadic case.

A sporadic case of the intestinal-type sinonasal adenocarcinoma is described. The patient was a comparatively young 33-year-old woman employed as a senior biochemical scientific technologist for several years. The light microscopical pattern was that of a papillary-tubular adenocarcinoma with areas of more solid mucinous elements in the deeper parts of the neoplasm. The neoplasm had invaded the nasal septum and reached the left orbit invading the left ethmoidal sinus. The glands were lined by columnar cells with elongated spindle-shaped nuclei and the cells expressed cytokeratin, carcinoembryonic antigen (CEA), Chromogranin A, gastrin and serotonin but not neurone-specific enolase (NSE) nor synaptophysin. Neurosecretory granules were present. There was no history of wood dust inhalation and her exposure to chemicals is of some interest but had probably little or no role in the causation of this neoplasm.

Adenocarcinoma, Papillary↗
PubMed1996

Vaches folles?

Explore the source record for details and available documents.

Czechoslovakia↗
PubMed1994

Ossified thyroglossal cyst--is it of embryological significance?

We report a case of a partly ossified thyroglossal cyst in close proximity to the hyoid bone and discuss the possible embryological significance of this. Thyroglossal cysts occurring within the hyoid bone or deep to the hyoid periosteum support previous suggestions that the thyroglossal tract can sometimes be trapped within the developing hyoid bone.

Aged↗
PubMed1993

Epidemic typhus fever and hearing loss: a histological study (Hallpike collection of temporal bone sections).

Hearing loss as a frequent complication of louse-borne epidemic typhus fever has been well documented in the reports of ENT specialists serving in both the Allied and the German armies in the last war. The present paper describes the characteristic histopathological features as noted in sections of the temporal bones from five British soldiers who died in 1944 of typhus fever during the last war in Eastern Asia. The VIIIth nerve showed multiple 'typhus nodules' and there was extensive interstitial neuritis of the VIIIth nerve and demyelination of the nerve fibres. There were also widely scattered aggregations of mononuclear cells in the inner ear. This unique study was based on the Hallpike collection of temporal bone sections.

Adult↗
PubMed1992

Necrotizing sialometaplasia.

Necrotizing sialometaplasia is a benign self-limiting disorder which can simulate malignancy. We report the third such case of nasal fossa involvement in the literature. The pathology of this condition is discussed.

Humans↗
PubMed1991

Contribution of immunohistochemistry in the diagnosis of neuroendocrine neoplasms of the larynx.

This chapter illustrates the use of mono- and polyclonal antibodies as diagnostic tools for neuroendocrine neoplasms of the larynx on the basis of data from the literature and the authors' personal experience. It is suggested that a panel of antibodies should be adopted, rather than to rely on the specificity and sensitivity of a single marker. It is also emphasized that immunohistochemical methods should serve not as a substitute but as a useful adjuvant in evaluating the morphological criteria of these neoplasms.

Antibodies, Monoclonal↗
PubMed1990

Pathological lesions of the external auditory meatus: a review.

A closer study of the pathology of the external auditory meatus shows that there are various non-neoplastic and neoplastic diseases of local origin which are of great clinico-pathological importance. These include Kimura's disease and angiolymphoid hyperplasia with eosinophilia; progressive necrotizing (or malignant) external otitis. Osteoma and ceruminoma are typical neoplasms of the external auditory meatus which is also the site of polypoid granulomatous or neoplastic structures arising from the middle ear cleft. These so-called 'aural polyps' often dismissed as of little or no diagnostic importance, may contain significant clues to a serious underlying infection or to a malignant neoplasm. Profuse bleeding may ensue on removal of such polyps. The histopathological features and their significance are described and discussed.

Ear Diseases↗
PubMed1990

Immunohistochemistry of otosclerosis.

Immunoglobulins G (IgG) and A (IgA) were found in plasma cells, osteocytes, chondrocytes and in connective tissue of active otosclerotic (= otospongiotic) lesions. The application of antibodies against paramyxovirus and rubella virus antigens reproducibly determined the expression of these antigens at different sites in the otosclerotic stapes, but also in the epithelial cells of the overlying middle ear mucosa. By using specific T-lymphocyte and B-lymphocyte markers, about 80% of the lymphocytes present in the otosclerotic footplate were revealed to be T-lymphocytes. There was neither deposition of immunoglobulins nor any expression of viral antigens in non-otosclerotic footplates which were investigated as controls.

Adolescent↗