Biomedical subjects
Publications and source records attributed to I Finger.
This clinical report presents a method of satisfactorily restoring a patient with a Class V mandibular defect. Conventional restoration of this patient would have consisted of a soft tissue-supported prosthesis with its inherent instability and associated problems. The use of implants has provided stability and function unobtainable with conventional prosthesis for this patient.
The dental literature is replete with information on various implant surgical template designs and imaging techniques for presurgical assessment of dental implant sites. Seldom are these two aspects combined in a practical and effective manner to fabricate a guide for precise implant placement. Unless detailed, three-dimensional images of the underlying bone are obtained, the use of a template is ineffective. This article describes a radiographic/surgical template that utilizes a series of telescoping metal tubes as radiographic markers and as implant drill guides.
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An occlusally worn or broken-down denture can present problems for the patient who must wear it and challenges for the dentist who must correct the condition. Many times an alternative to replacing the denture must be found. A method of restoring the occlusal surface of a worn or broken-down complete-arch fixed implant prosthesis is described.
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There is a report on rehabilitation results of chronic patients after 10-years-follow-up in a psychiatric community hospital. Indication for therapy, prognosis and main fields of treatment are differently dependent on variable diseases according to the diagnostic classification given by Leonhard. Where as illness duration and professional basis don't correlate with favourable rehabilitation results additional accentuated behaviour and unfavourable social situations in interhuman relations render the rehabilitative therapy more difficult. Future research into that direction might be a basis for more effective therapeutic action.
The relationship of maternal behavioral style to the cognitive developmental status of 60, 1-, 2-, and 3-year-old organically impaired, mentally retarded children was investigated. Eighteen global maternal behaviors and four child behaviors were rated on a 10-minute video tape of mother-child play. A factor analysis of the maternal behavioral items revealed three major parameters of behavior. Child-Oriented/Maternal Pleasure was related positively, whereas Quantity of Stimulation and Control were related negatively to Children's Bayley Mental Development scores. Maternal behavioral style was not related to either the ratings of the children's behavior or to the children's current health status and family SES, but was related to the amount of time children had been in intervention programs. Findings were discussed in terms of their implications for intervention with mothers and their retarded infants.
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The relationship between sensorimotor and language development of Down syndrome and nonretarded children was investigated. The Ordinal Scales of Psychological Development (Uzgiris & Hunt, 1975) and the Receptive and Expressive Emergent Language (REEL) scale (Bzoch & League, 1970) were administered to 18 Down syndrome and 18 nonretarded children who had matched developmental ages of approximately 17 months. Comparison of the resulting scores indicated that although there were no differences between the groups on four subscales of the Uzgiris-Hunt, there were significant differences in favor of the nonretarded children on the Vocal Imitation subscale of the Uzgiris-Hunt and on Receptive and Expressive measures of the REEL. These results indicate that Down's syndrome children are delayed in their language development compared to nonretarded children of the same developmental age. This language delay appears to be related to deficiencies in vocal imitation skills but is not related to general sensorimotor functioning.
Paramecia may induce in other paramecia specific changes in the expression of genes determining surface protein synthesis, probably via cell-to-cell contact. Transformation from one antigenic type to a newly induced one is stimulated by the pretreatment of a cell with 5-fluorouracil. These observations are considered in terms of the regulation of the activity of genes in stable cells and in unstable cells which tend to transform spontaneously.
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A previously demonstrated high rate of failure on a Stage 6 sensorimotor means-end problem, of children otherwise inferred to be in Stage 6 development, prompted a study of task characteristics of the problem. A component part of the task was modified by introducing an additional visual cue; the purpose of the problem was unchanged. Results indicated that problem solving was facilitated in the transformed condition, with older subjects performing somewhat better than younger subjects. The authors suggest that cognitive requirements of the problem, as representative of Stage 6 sensorimotor development, remained the same in the original or transformed condition. The modification appeared to permit children to focus their attention on the requirements of the problem, so that a greater number of children demonstrated mental representation. Task characteristics of sensorimotor problems need to be investigated further.
The synthesis of a surface protein has been studied in Paramecium through double-labeling experiments using [(14)C]- and [(3)H]leucine-labeled bacteria as the source of radioactive amino acid. Over a 4-5 h incubation period, the turnover rate was found to be higher than that of overall cell protein. In addition, the initial label is apparently utilized during the chase period, being incorporated into protein via a puromycin insensitive pathway.
Clones of Paramecium of identical serotype when cultured in test tubes may differ in their ability to give rise to subclones of this serotype. Characteristically, stable clones yield progeny indistinguishable from their parents, while from unstable clones diverse subclones with new serotypes can be isolated repeatedly. Stable lines are resistant to changes in culture medium and also are unaffected by most sera. In contrast, the numbers and kinds of serotypes displayed among subclones derived from unstable lines are often affected by these same agents. Stable and unstable clones are interconvertible when the medium from individual cultures is repeatedly and frequently replaced by fresh culture fluid. This effect is very likely a result of the removal of the initial exhausted medium with any cell products rather than the addition of fresh nutrient.
Paramecium generally expresses only one antigen on its surface from among an array of antigens. This mutual exclusion of antigens now has been shown in certain instances to be illusory. Unstable clones which will give rise to subclones with new serotypes possess several antigens. Unstable clones, even though they manifest only one serotype, continually manufacture an antigen other than the surface antigen characteristic of the serotype.
Clones of genetically uniform paramecia differ in the extent to which they retain the antigenic type of a common ancestor. Some are faithful and are considered stable. Others are unstable. Apparently there are two kinds of "unstable" clones. One is composed of cells all of which tend to produce subclones with some cells which have transformed to new serotypes. Other "unstable" clones apparently are really composed of two or more kinds of cells, each of which tends to yield subclones which are made up almost exclusively of cells of one serotype, although some of these subclones are not of the original serotype. Support for the existence of such heterogeneous unstable clones is presented, and several possible mechanisms to account for their existence are discussed.
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