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Biomedical subjects

I Feigin

Publications and source records attributed to I Feigin.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Some chemical principles applicable to some silver and gold staining methods for neuropathological studies.

Some of the chemical principles involved in some silver and gold staining procedures for neuropathological studies are analyzed in the light of experience with methods for astrocytes, microglia, axons and reticulin fibers. The role of formalin fixation, and of treatment with ammonium bromide or oxidizing agents prior to staining for glial cells or reticulin fibers respectively, is described. The silver staining methods are divided into two fundamentally different groups. One is based on the use of silver diammine solutions with or without other substances such as carbonates or pyridine, and at varying times, gold toning. This group encompasses a great variety of techniques for staining glial cells, reticulin fibers and axons. The second group is based on the use of weak solutions of silver ions, reduction in a photographic developer, treatment with gold chloride, and a second reduction in oxalic acid. This group is represented by methods for staining axons and reticulin fibers. A brief analysis of the gold and mercuric chloride methods for astrocytes is also given.

Astrocytes↗
PubMedDate not supplied

Sarcoma arising in oligodendroglioma of the brain.

A case is reported of a tumor composed of both oligodendrogliomatous and sarcomatous elements. The interpretation is offered that the sarcoma arose secondarily by neoplastic transformation of the hyperplastic blood vessels formed in response to the presence of the oligodendroglioma. This tumor may be considered analogous to the astrocytoma-sarcoma, which is much more common, and to the metastatic carcinoma with secondary sarcoma, of which one case has been reported.

Brain Neoplasms↗
PubMedDate not supplied

Subacute necrotizing encephalomyelopathy in a neonatal infant.

This infant, born after a normal pregnancy by cesarean section, appeared entirely normal for the first 44 hours of life, at which time she was found to have become completely apneic, suddenly and without known cause. The infant was resuscitated, placed in a respirator, treated energetically but with limited response, and expired 15 days later. At autopsy, bilaterally symmetric lesions were found in the walls of the third ventricle, the periaqueductal gray matter and the floor of the fourth ventricle, characterized by marked destruction of most neural elements, but with a selective preservation of neurons and their processes. The process is interpreted as that of subacute necrotizing encephalomyelopathy. Many of the preserved neurons had reacted by a multiplication of nuclei, as many as 11 being present in a single cell. Binucleated macrophages were also present; There were hypoxic changes as well, with a loss of neurons in the hippocampal gyrus, and with basophilic PAS positive granules in the cytoplasm of many neurons, some containing iron. If resuscitation had failed this would have been considered a "crib death". The possibility exists that some other cases of crib death may be of this nature.

Brain↗