[Radiochromatographic analysis of irradiation cleavage products of thymine-C-14].
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Biomedical subjects
Publications and source records attributed to I Elekes.
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The biotransformation of the labelled forms of 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethyoxy-5H-2,3-be nzodiazepine (Grandaxin, tofizopam) has been investigated after oral administration in animals and man. The major part of urinary metabolites was found to be conjugated with glucuronic acid. The metabolites were separated using TLC technique and analysed by GLC and GLC-MS. The chief way of the metabolic information of tofizopam is demethylation, however, the position of CH3 elimination as well as the rate of it was different in various species.