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Biomedical subjects

I Eichler

Publications and source records attributed to I Eichler.

64 records · Page 4Linked to original sources
PubMed1983

[Tumors of the 4th ventricle and the craniospinal transitional zone. Review of patients of the Neurosurgical Clinic of the Department of Medicine of the Karl Marx University].

From a total of 1,028 infratentorial tumours operated on at the Neurosurgical Hospital of the Section Medicine of the Karl-Marx University Leipzig in the last 30 years, 167 tumours in the region of the 4th ventrical have been selected. Their statistical processing was carried out with respect to specific localisation, average age, kind of tumour, sex, clinical findings, duration of case history, application of instrumental diagnostic procedures and radicality of operation, success and failure. Some fundamental conclussions are drawn. A subdivision in detail will be contained in the following articles based on this material.

Adolescent↗
PubMed1983

[Special diagnostic and surgical problems in tumors of the 4th ventricle in adulthood].

Within 30 years, 1028 operations because of cerebellar tumours have been carried out at the Neurosurgical University Hospital in Leipzig. Of these, 167 were related to tumours within the 4th ventricle or encroaching a little outside of it. In the group of the adults (from the 18th year), 54 observations were made. These patients are subdivided according to histology (ependymomas in the first place), according to clinical findings (high values of cerebral pressure symptoms), according to the duration of the case history in dependence upon histology (long duration of angioblastomas and ependymomas), according to the possibilities of radicality (somewhat below the values in child age), the condition at discharge (better than in child age) and the cause of death (absolute predominance of central causes). A comparison is made with the results obtained with the studied patients in child age. Subsequently, the operation tactics of the Leipzig hospital is dealt with and the respective value of microneurosurgery carried out 10 years before is emphasised. A striking improvement for benign tumours can now only be achieved by a considerably improved early diagnosis.

Adolescent↗
PubMed1983

[Special diagnostic and surgical problems in tumors of the 4th ventricle in childhood].

A report is given on 113 tumours of the 4th ventricle in children (up to the age of 18 years) observed among a total of 1028 cerebellar operations. Of these, 87 (= 77%) tumours were exclusively tumours of the 4th ventricle, in 26 cases the tumour also encroached on adjacent structures (cerebellar hemisphere and vermis, pons and Medulla oblongata). Medulloblastomas were predominant (55%), they mainly occurred in school age. Leading clinical symptom of the tumours of the 4th ventricle - especially in child age - is the increase in intracranial pressure which can often be demonstrated radiologically in this age group. Besides there are coordination disturbances and disturbances of the cerebral nerves; relatively frequently one sees a "vermis syndrome". The initial symptoms, which are in most cases non-characteristic (nausea, headache, also ataxia), are more often than not misinterpreted. Surgically treatment aims at a radical removal of the tumour whenever of possible, which is frequently problematic in children, and the restoration of the pathways the cerebrospinal fluid. Microsurgical techniques clearly contributed to a decrease in the mortality rate which, however, still is very high. This stresses the importance of an improvement of early recognition of these tumours.

Adolescent↗
PubMed1983

[Special problems in the diagnosis and therapy of craniospinal tumors].

Tumours in the region of the Foramen magnum are rare (34 cases among more than 1000 infratentorial and 400 spinal tumours). The clinical symptoms can be guiding but they sometimes involve differential-diagnostic difficulties. In dependence upon the starting point and the direction of the development, cerebellar signs or transverse paralysis in the cervical region of the medulla are in the fore. In most cases, supplementary examinations are indispensable (X-ray examinations of the skull and the cervical vertebral column, ventriculography and CT). Angiography is of lesser importance. The anatomical relations of the tumour to its environment not only form the clinical picture, but also bring about therapeutical problems. The use of microsurgical methods has improved the prognosis a little, but nevertheless these disease pictures should be considered to be very serious.

Adult↗
PubMed1983

[Combination treatment of medulloblastomas].

At the time being, the therapy of malignant cerebral tumours cannot yet be considered to be satisfactory. By a combination of various forms of therapy, surgery, radiation therapy, chemotherapy, one tries to achieve optimum results. With respect to the results of the therapy (survival time and survival quality), the medulloblastoma occupies a special position. By employing the combined method, the survival time and also the survival quality can be considerably increased. By the example of one case, the course of the disease in a young medulloblastoma patient is shown whose survival time was six years.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

[Therapy of malignant supratentorial neuroepithelial tumors and the possibility of the pretherapeutic sensitivity testing of cytostatics].

Today, the treatment of malignant gliomas is carried out surgically, radiotherapeutically or chemotherapeutically. In the field of radiotherapy, promising trials with radiosensitizers have been carried out which might increase the effectiveness of the irradiation of gliomas. Chemotherapy without a combination with the other above mentioned therapies is not promising. Test models for the pretherapeutic prediction of the individual cytostatic activity are available both in the form of experiments and short-term or long-term in-vitro tests without any of the test models having sufficiently reflected the in-vivo conditions up to now.

Antineoplastic Agents↗