Biomedical subjects

I Drury

Publications and source records attributed to I Drury.

58 records · Page 4Linked to original sources

PubMedDate not supplied

Longitudinal EEG studies in a kindred with Lafora disease.

We reviewed 18 EEG studies in four members of a family with the Lafora form of progressive myoclonic epilepsy. Each patient was the product of a consanguinous marriage and presented as a teenager with progressive seizures, myoclonus, dementia, and ataxia, and had biopsy proven disease. The EEG early in Lafora disease has spike-wave activity resembling that seen in a primary generalized epilepsy; the background slowing is more typical of a secondary generalized epilepsy. With disease progression, there is increased epileptiform activity, and a striking change in the spike-wave complexes, with a marked increase in frequency up to 6-12 Hz, and many more short duration polyspike components. Unlike some other forms of secondarily generalized epilepsy, the EEG in Lafora disease is distinguished by an increased frequency of the spike-wave complexes with disease progression.

Adolescent↗

PubMedDate not supplied

Generalized spike-waves, multiple loci, and clinical course in children with EEG features of benign epilepsy of childhood with centrotemporal spikes.

In 41 patients with EEG features of benign epilepsy of childhood with centrotemporal spikes (BECCT), we noted associated generalized spike-wave discharges (GSWD) in 14.6% and multiple independent sharp wave foci in 9.8%. The presence or absence of these EEG features was not predictive of the clinical course. The high incidence of GSWD in children with BECCT suggests a possible relation in the expression of these two EEG traits.

Adolescent↗

PubMedDate not supplied

Focal cerebral magnetic resonance changes associated with partial status epilepticus.

We report 2 patients with transient abnormalities on magnetic resonance imaging (MRI) associated with partial status epilepticus (SE). A man with a 4-month history of partial seizures had complex partial SE for 9 days, with left temporal maximum on ictal EEG. Left temporal lobe T2 signal was increased on MRI during SE, but cerebral MRI was normal 9 weeks later. A woman with "cryptogenic" temporal lobe epilepsy for 16 years had complex partial SE for 1 week, with right temporal maximum on ictal EEG. T2 Signal was increased over the entire right temporal lobe, extending into the insula, without mass effect, on MRI 1 month after SE ended. Repeat MRI 1 month later showed marked decrease in volume of increased T2 intensity, without gadolinium enhancement, but with mild mass effect over the right anterioinferomesial temporal areas. A gemistocytic astrocytoma was resected. Focal cerebral MRI abnormalities consistent with cerebral edema may be due to partial SE but also may indicate underlying glioma, even in long-standing partial epilepsy. Focal structural imaging changes consistent with neoplasm should be followed to full resolution after partial SE.

Adult↗

PubMedDate not supplied

The changing pattern of survival following stroke.

This study, compared survivorship for first episodes of cerebral infarction, intracerebral hemorrhage and subarachnoid hemorrhage which occurred in residents of Rochester, Minnesota during 5-year periods from 1945-49 through 1975-79. The progressive improvement in long-term survival following cerebral infarction which occurred between 1945-49 and 1970-74 was such that a higher proportion of patients survived for six years in 1970-74 (45%) than survived for three years in 1945-49 (42%). A modest improvement in short-term survival following cerebral infarction occurred up to 1975-79 but a marked improvement in 30-day survival following intracerebral hemorrhage was noted. The reasons for the improvement in survival have not been established, but possible changes in the diagnosis and management of stroke which might have been contributory factors are discussed.

Cerebral Hemorrhage↗