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Biomedical subjects

I De Wever

Publications and source records attributed to I De Wever.

70 records · Page 4Linked to original sources
PubMed1991

Cytogenetic characterization of congenital or infantile fibrosarcoma.

Chromosome analysis of a congenital or infantile fibrosarcoma from the lower left leg of a 3-week-old baby girl showed only numerical changes involving chromosomes 11, 17 and 20. As three more cases with similar combinations of trisomies of the same chromosomes have been described, this report confirms that adult and congenital fibrosarcoma are cytogenetically different and trisomy 11 may be the key-event.

Chromosomes, Human, Pair 11↗
PubMed1991

A variant (2;13) translocation in rhabdomyosarcoma.

Cytogenetic analysis of a right buttock mass from a 5-year-old boy showed translocation between an inverted chromosome 1 and a chromosome 13 as the sole cytogenetic abnormality. The breakpoint 13q14 appears to be the same as in previously reported cases of rhabdomyosarcoma (mostly of the alveolar type), but does not show involvement of 2q37. We suggest that this translocation may be a variant of the classical t(2;13)(q37;q14) found in rhabdomyosarcoma.

Child, Preschool↗
PubMed1990

Inflammatory pseudotumor of lymph nodes. Immunohistochemical evidence for its fibrohistiocytic nature.

Five cases of inflammatory pseudotumor (IPT) of the lymph node were investigated by means of light microscopy and immunohistochemistry to elucidate its cellular composition. The IPT is composed of a proliferation of spindle cells, inflammatory cells, and small vessels, forming high and poor cellular areas. Many spindle cells correspond to activated histiocytes as they coexpress vimentin and macrophage-associated markers; they are intermingled with vimentin-positive fibroblasts and variable numbers of vimentin- and actin-positive myofibroblasts. This mixed-cell proliferation invades and/or destroys medium- and large-sized vessels in all cases. This study indicates that the spindle cell proliferation, identified as histiocytic and fibroblastic in nature, represents the main component of the nodal IPT. We speculate that release of cytokines by the activated histiocytes may result in the development of the complex histopathologic aspects of this inflammatory process and, if inappropriate, may represent the underlying pathogenic mechanism.

Actins↗
PubMed1984

Different meals produce different digestive motility patterns.

The purpose of these experiments was to characterize the pattern of digestive myoelectric activity produced by four different test meals in dogs. A new approach for the analysis of the myoelectric activity of the small intestine was used. In contrast with methods dividing the tracings into present time periods, the present method respected the "motor entities," hence the continuity, of the tracing. Two types of motor entities occurred: "activity units" which are groups of consecutive slow waves with spiking, and "rest units," which are groups of consecutive slow waves without spiking. The frequency of occurrence and frequency of alternation of the various activity and rest units occurring during digestion was calculated. Digestive myoelectrical activity was characterized by the frequent occurrence and alternation of short activity and rest units. Three different patterns of digestive activity could be discriminated, ie, a fat, a protein and carbohydrate, and a canned food pattern.

Animals↗
PubMed1984

Intestinal motility after infusion of arachis oil into duodenum and ileum of dogs.

Arachis oil and a mixture of arachis oil with bile and pancreatic enzymes were infused into the duodenum and ileum of dogs via surgically positioned catheters in order to study the mechanism of disruption of the migrating complex by intraluminally infused triglycerides, the importance of cholecystokinin and neurotensin in this event, and the pattern of digestive myoelectrical activity during fat digestion. When infused into the duodenum both arachis oil and the oil-bile-pancreatic enzyme mixture disrupted the migrating myoelectric complex (MMC). When infused into the ileum, only the oil-bile-pancreatic enzyme mixture disrupted the MMC. The duration of the disruption lasted as long as when the same amount of oil was administered orally. Triglyceride-induced digestive activity was characterized by the frequent alternation of short periods of spiking activity and short periods of quiescence. It is concluded that the triglyceride-induced disruption of the MMC-pattern is not caused by the triglyceride itself but by some emulsion or digestion product. We further suggest that the disruption is hormonally mediated and due to fat-stimulated neurotensin, rather than cholecystokinin (CCK), release.

Administration, Oral↗
PubMed1980

Local disorganization of interdigestive migrating complex by perfusion of a Thiry-Vella loop.

In dogs, a 50-cm Thiry-Vella loop was perfused with different glucose solutions (10-60%) and the effect on the interdigestive migrating myoelectric complex was studied. The perfusions did not disrupt the interdigestive pattern outside the loop, but produced a progressive "fall-out" of phase III, related to the concentration of the glucose solution. Quantitative analysis of the spike activity in the loop showed that the interdigestive pattern was partially disrupted by the 10% glucose solutions and that the 50 and 60% glucose perfusions induced a typical fed pattern characterized by short periods of spike activity alternating with short periods of quiescence. It was concluded that 1) perfusion of a Thiry-Vella loop with glucose solutions changes the myoelectrical activity of the loop from an interdigestive to a digestive pattern without interfering with the migrating myopelectric complex outside the loop; and 2) this local disorganization must be mediated by factors interfering with the effector mechanism in the loop.

Action Potentials↗
PubMed1978

Disruptive effect of test meals on interdigestive motor complex in dogs.

The disruptive effect of food and food components on the migrating myoelectric complex (MMC) was studied in conscious dogs. Three types of test meals were fed, and the interval between feeding and the reappearance of the first phase III of the MMC was determined. When commercial dog food was used a linear relation was observed btween the quantity of food (expressed as kcal/kg body wt) and the duration of the disruption of the MMC. Equicaloric amounts of the three major food components disrupted the MMC pattern for periods of time that were related to the nature of the food: the effect of arachis oil lasted longer than that of sucrose and much longer than that of milk protein. Medium chain triglycerides had a potent disruptive effect. Mixtures of these food components produced a disruptive effect that could not be calculated from the individual effect of each component. Phase III of the first and second MMC after feeding started at a lower level of the intestine than after a long fast. The duration of disruption of the MMC after a meal depends much more on the physicochemical composition of the food than on its volume or amount of calories.

Action Potentials↗
PubMed1978

Role of gastrin and insulin in postprandial disruption of migrating complex in dogs.

The duration of the disruption of the interdigestive migrating myoelectric complex (MMC) by various test meals in dogs was correlated with changes in serum gastrin and insulin levels. The test meals consisted of milk protein, sucrose, arachis oil and medium chain triglycerides (MCT). Intravenous infusions of glucose 20% were also used. Electrical activity of the small intestine was registered by means of electrodes implanted over the entire length of the gut. Hormones were assayed by radioimmunoassay techniques. The insulin level rose significantly after both the glucose infusion and the sucrose meal. The rise was small after the milk protein meal and nothing after arachis oil and MCT. Gastrin level was not changed by arachis oil or MCT and rose slightly after sucrose and milk protein. The MMC was not disrupted by glucose infusions, but was disrupted for 5--7 h by archis oil and for 6--12 h by MCT. We conclude that in dogs neither gastrin nor insulin have an important role in the mechanism of disruption of the MMC after feeding.

Action Potentials↗
PubMed1976

Peristalsis in smooth muscle esophagus after transection and bolus deviation.

The importance of the continuity of the muscle coat and of the presence of an intraluminal bolus for the peristaltic performance of the Rhesus monkey esophagus was studied. Transection and reanastomosis with muscle-to-muscle contact in the striated muscle part of the esophagus did not interfere with the progression of primary peristaltic contractions. However, when the transection with reanastomosis was performed in the smooth muscle part of the gullet the peristaltic progression of the deglutitive contraction waves in the segment below the transection was affected. After deviation of the swallowed bolus either in the cervical striated esophagus or in the smooth muscle part of the thoracic esophagus, primary peristaltic contractions were seen to progress over the entire length of the gullet; however, in the thoracic esophagus the presence of a bolus facilitated the peristaltic progression of primary waves. These studies also indicate that the extramural vagal innervation is involved in secondary peristaltic contractions of the smooth muscle esophagus.

Animals↗
PubMedDate not supplied

Surgical interventions during STI 571 treatment of metastatic GIST: experience in six patients.

Gastrointestinal stromal tumours (GIST), previously classified as smooth muscle tumours, are the most common mesenchymal tumours of the digestive tract. Since the discovery of KIT (CD 117) expression, these tumours can be diagnosed confidently by pathology. Until recently, surgery was the only treatment available because these tumours were not sensitive to chemotherapy nor radiation therapy. In the long run most of these tumours recurred in the abdominal cavity or in the liver. Recently a new drug STI 573 (Glivec) showed very promising results in metastatic disease with response rates of about 65%. In six patients treated at our center, surgery was indicated during STI therapy because of subobstruction, skin necrosis, abdominal distention, bleeding. Surgery proved to be safe and efficient, allowing continuation of STI therapy in much better circumstances.

Adult↗
PubMedDate not supplied

Vacutainer filling time through subcutaneous venous access devices.

INTRODUCTION: The functionality of subcutaneous venous access devices is evaluated at least every time the device is accessed. This evaluation is subjective and actions are only undertaken when blood withdrawal and/or fluid injection become problematic. The function of these devices has rarely been evaluated objectively. The present study tried to find an objective and standardized way to evaluate the withdrawal speed of a newly inserted port. METHODS: Between October 2001 and December 2002, a prospective randomized study of 3 types of ports was carried out. The ability to infuse heparinized normal saline and to withdraw blood was evaluated by recording the filling time of a 10 ml Vacutainer tube in 876 newly inserted central venous ports at the end of the surgical procedure. RESULTS: The patient groups were comparable in age, gender and insertion procedure characteristics (vein used, position of the port on the body and length of the catheter). The median time needed to fill a 10 ml Vacutainer tube in all ports was 17.00 sec (range 11.43-63.62 sec). The median filling time for BardPort was 16.36 sec (range 13.48-39.00 sec), for Celsite 18.35 sec (range 12.03-40.00 sec) and for Port-a-cath 16.43 sec (range 11.43-63-62 sec). A significant difference in filling time was found between the large bore catheters (BardPort, Port-a-cath) and the small bore catheter (Celsite) of 2 seconds median value. CONCLUSION: Measurement of withdrawal speed provides an objective criterion for the quality description of blood withdrawal immediately after insertion. A value of more than 20 seconds for filling a 10 ml Vacutainer tube could therefore be suggested a useful trigger for further investigation.

Journal Article↗
PubMedDate not supplied

Infection assessment of totally implanted long-term venous access devices.

AIM: Comparison of catheter tip versus port content culture techniques to assess infection in totally implanted vascular access devices (TIVAD). MATERIALS AND METHODS: Comparison of pocket swab, catheter-tip and port content cultures after removing the silicon puncture septum in a prospectively collected consecutive series of 102 TIVAD removed for clinical suspicion of infection, between May 2000 and March 2003. RESULTS: 102 totally implanted port-catheters in 98 patients, age ranging from 1 to 90 years (median 53 years), were removed 7 to 2616 days after insertion (median 210 days). Infection of the pocket surrounding the port was found in 21 cases, all proven by a positive culture of the pocket swab. Out of the remaining 81 cases without pocket infection, 32 had only a positive catheter tip culture, whereas 56 had a positive port content culture (p = 0.0002). Always the same microorganism was isolated in the 32 patients with positive catheter tip and port content cultures. The main organisms identified within TIVAD were Coagulase Negative Staphylococcus (CNS) (41 cases) and Candida sp (15 cases). Eight out of the 21 pocket infections were caused by Staphylococcus aureus. CONCLUSION: In the presence of local signs of infection, taking cultures of the pocket surrounding the port is sufficient for diagnostic purposes. When infection is localized within the device only, port content cultures taken after removal of the silicon septum are more often positive than cultures of the catheter tip, and constitute therefore a more reliable tool for the assessment of TIVAD infection.

Adolescent↗
PubMedDate not supplied

Inguinal hernia repair leading to the diagnosis of internal male pseudohermaphroditism.

Surgical hernia repair in an apparently normal man leaded to the diagnosis of internal male pseudohermaphroditism after removal of a cystic structure which proved to be a remnant of the Müllerian duct on microscopic examination. The diagnosis was confirmed at explorative laparotomy in search of the second testicle. The terminology of the condition is reviewed and the therapeutic attitude is discussed.

Adult↗