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Biomedical subjects

I D Cox

Publications and source records attributed to I D Cox.

26 records · Page 2Linked to original sources
PubMed1987

Significance of tomographic signs in the diagnosis of bronchial carcinoma.

In a previous study the value of conventional tomography was assessed in the diagnosis of 100 potentially malignant opacities on the chest radiograph. To determine which of the radiological signs were most useful the radiologists reviewed 82 of the original 100 radiographs independently, searching for the presence or absence of 36 signs. The five commonest signs of bronchial carcinoma were a mass, coarse linear shadows contiguous to a mass, unilateral hilar enlargement, linear shadows from mass to periphery, and an irregular margin to a mass. The combination of either two or three of these signs was highly sensitive, 95% and 89% respectively, in detecting carcinoma. The most useful specific signs were lobulation of the mass and cavitation with thick or irregular walls.

Bronchography↗
PubMed1984

An electromyographic method of objectively assessing cough intensity and use of the method to assess effects of codeine on the dose-response curve to citric acid.

The integrated surface abdominal electromyogram (EMG) has been used as a simple measurement of cough intensity which correlates well with the volume, air flow and noise produced in different coughs. Using the integrated abdominal EMG as a measure of cough intensity, dose response curves to inhaled citric acid can be drawn which are highly reproducible. We have studied the effects of codeine (60 mg) on these curves, and have demonstrated a reduction in cough intensity. It is suggested that this method of testing the effects of an antitussive on such a dose-response curve may be a useful one.

Action Potentials↗
PubMed1984

Ipratropium bromide in patients with nocturnal asthma.

Fourteen patients with nocturnal asthma were recruited to a two period crossover trial which compared a run-in period on nightly salbutamol (200 micrograms) with a period on nightly ipratropium bromide (160 micrograms) and a period on nightly salbutamol plus ipratropium at night. Morning dipping, as assessed by the fall in peak flow overnight, was significantly reduced in the periods when ipratropium bromide was taken. Peak flow in the morning and also at night was improved when taking ipratropium bromide. Ipratropium bromide in adequate dosage appears to be effective in reducing morning dipping in asthma.

Adult↗
PubMed1984

Assessment of conventional tomography and fibreoptic bronchoscopy in the diagnosis of potentially malignant chest opacities.

Conventional chest tomography and fibreoptic bronchoscopy were performed in 100 patients with a localised chest abnormality on their chest radiographs who had been referred with a possible diagnosis of bronchial carcinoma. Carcinoma was eventually confirmed in 74 cases and in 26 the lesion proved to be benign. The accuracy of tomography in the overall series was 83%, with a sensitivity of 92% and a specificity of 58%. These figures compare favourably with the results of other imaging techniques used in the diagnosis of bronchial carcinoma. In 50 patients bronchoscopy did not suggest carcinoma and in this group of patients 24 had a carcinoma and 26 a benign lesion. The accuracy of tomography in the bronchoscopy negative patients was 74%, the major source of error being the false positive category. The lesion eventually proved to be benign in 33% of the cases where tomography suggested malignancy, but when the tomograms suggested that the lesion was benign a tumour was found to be present in only 12% of cases.

Aged↗
PubMed1984

Relationship of radiologic position to the diagnostic yield of fiberoptic bronchoscopy in bronchial carcinoma.

The radiologic position of tumors in 100 patients with bronchial carcinoma was compared with the diagnostic yield from fiberoptic bronchoscopy. A new method for dividing the chest x-ray film into three areas (hilar, perihilar, and peripheral) was based upon the expected range of vision of the fiberoptic bronchoscope. At bronchoscopy without fluoroscopy, only eight (36 percent) of 22 radiologically peripheral tumors were diagnosed, compared with 31 (94 percent) out of 33 hilar tumors (p less than 0.001) and 34 (76 percent) out of 45 perihilar tumors (p less than 0.01). The results show that in hilar and perihilar tumors, fiberoptic bronchoscopy gives a high diagnostic yield, whereas in peripheral tumors the yield is poor. This method allows the clinician to judge from the chest x-ray film whether a tumor is likely to be visible bronchoscopically. Thus, in radiologically peripheral tumors, as defined by our method, fluoroscopy at the time of fiberoptic bronchoscopy should be available to the clinician, or alternative diagnostic methods should be considered.

Bronchoscopy↗