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Biomedical subjects

I Cullhed

Publications and source records attributed to I Cullhed.

At least 37 records · Page 2Linked to original sources
PubMed1976

Videodensitometry in the diagnosis of aortic incompetence.

The videodensitometer has been used in a group of 20 patients with aortic incompetence and incompetence combined with stenosis. The method appears effective in the preoperative evaluation of the valvular and ventricular function of the patient. It gives objective and probably more accurate information of the regurgitation fraction and the ejection fraction than the commonly used semiquantitative methods. The method is simple to use and needs no technical changes in the roentgen equipment.

Absorptiometry, Photon↗
PubMed1975

Cardiovascular and respiratory effects of the beta-adrenoceptive antagonist sotalol: studies in health, angina pectoris and obstructive lung disease.

The cardiovascular and respiratory actions of the adrenergic beta adrenoceptive drug sotalol have been studied in an open, short term trial. Fifteen patients with angina performed standardized orthostatic and exercise tests before and after injection of 20 mg sotalol intravenously. Although there was a significant reduction of heart rate and blood pressure at the time of appearance of angina pectoris and ST-segment depression, there was only a slight and statistically insignificant increase in work before the appearance of angina pectoris, and ischaemic changes in the ECG disappeared more rapidly after work. In a different group of patients suffering from obstructive lung disease, sotalol 10 mg intravenously produced a significant increase in airway resistance. It has no such effect on normal subjects.

Adult↗
PubMed1975

Resection of lef ventricular aneurysm-late results.

A survey of 22 patients operated on with left ventricular (LV) infarctectomy during 1967-72 is given. Clinical, haemodynamic and angiographic results are discussed. In most patients, in whom pre- and postoperative examination was possible, there was improvement concerning anginal pain, dyspnoea and attacks of ventricular tachycardia. Exercise studies revealed a lower heart rate at follow-up. In general, heart size had decreased. Angiographically, there was a decrease in end-diastolic and end-systolic heart volume postoperatively, with an increased LV ejection fraction.

Adult↗
PubMed1975

Aortic valve replacement with frame-supported autologous fascia lata grafts. II. Clinical and laboratory findings.

Thirty-five patients with a frame-supported autologous fascia lata graft implanted in the aortic annulus were investigated 11 to 36 months after operation. The group comprised 7 patients with pure aortic stenosis, 11 with combined stenosis and incompetence and 17 with pure aortic incompetence. Seven patients had concommitant mitral valve disease. The follow-up investigation included ECG, a work test on a bicycle ergometer, dynamic spirometry, roentgenological heart volume determination and haematological "screening tests" for intravascular haemolysis. Concomitant with a marked subjective improvement of the patients, there was a considerable objective improvement, as judged by physical working capacity, ECG signs of left ventricular hypertrophy and heart volume. The serum haptoglobin values were somewhat lower postoperatively (mean value 44 mg%), but no ahaptoglobinaemia occurred. Thus, no definite signs of intravascular haemolysis were noted. No thrombo-embolism occurred within this observation period, despite the fact that none of the patients with isolated aortic valve replacement were treated with anticoagulants. This investigation shows that a frame-supported autologous fascia lata valvular graft in the aorta can function well during a period of up to 3 years.

Adolescent↗
PubMed1975

Aortic valve replacement with frame-supported autologous fascia lata grafts. III. Haemodynamic and angiographic findings.

Thirty-two patients with a frame-supported, autologous, fascia lata graft implanted in the aortic annulus were investigated 11 to 36 months after the operation. The group comprised 7 patients with pure aortic stenosis, 10 with combined aortic stenosis and aortic incompetence and 15 with pure aortic incompetence. Six patients had concomitant mitral valve disease. The follow-up investigation included right heart and transseptal left heart catheterization, left ventricular angiocardiography through the transseptal route and a retrograde, supravalvular aortography with the cinétechnique. Cardiac output was essentially unchanged postoperatively. However, it had increased considerably in some patients in whom it was very low before the operation. Left ventricular systolic pressure decreased particularly in patients with pure aortic stenosis. Left ventricular enddiastolic pressure decreased from 12 to 7 mmHg at rest and from 25 to 18 mmHg during exercise. Left atrial (or pulmonary arterial wedge) mean pressure decreased from 14 to 2 mmHg at rest, and from 27 to 16 mmHg during exercise. In 76% of the patients a slight (grade I or II) central or paravalvular aortic regurgitation was observed on cinéangiograms. Regurgitation of grade III was found in one patient. Technical details in the construction of the valve, as well as structural changes in the fascia lata which may be responsible for stenosis and incompetence in some of these valves are discussed. Thus, although even patients with defective valves have shown considerable improvement, a close and continuous follow-up of these patients is necessary.

Adolescent↗