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Biomedical subjects

I Craft

Publications and source records attributed to I Craft.

At least 127 records · Page 7Linked to original sources

Plasma steroids in the foetal and maternal circulation at normal delivery and elective caesarean section.

Maternal and foetal plasma collected at normal delivery and at elective caesarean section was assayed for sex steroid levels. Foetal cord plasma concentrations of progesterone, 17-hydroxyprogesterone, oestrone and oestriol were higher than maternal values at normal delivery, whereas oestradiol levels were lower. Oestrone concentrations were higher than oestradiol in the foetal circulation at normal delivery and oestrone values were higher following normal delivery than at elective caesarean section.

Cesarean Section↗

Assessment of factors constituting an "inducibility profile".

A survey of 440 patients examined vaginally during the last month of pregnancy showed a correlation between quantitative assessment of the pelvic score features described by Bishop and the duration of induced labor. Cervical dilatation was as useful as the total Bishop score in this respect. Cervical dilatation and station of the head together were especially predictive for long labor and these two factors together with length of cervix were especially predictive for shorter labors. It was also apparent from this study that previous cervical surgery or vaginal termination of pregnancy was associated with a lower incidence of low Bishop scores. The changes in individual components of the Bishop score during the last month of pregnancy are described.

Cervix Uteri↗

Extra-amniotic prostaglandin E2 and the unfavourable cervix.

A small dose of prostaglandin E2 suspended in a viscous medium was instilled as a single application into the extra-amniotic space of patients with unfavourable induction features the day before planned induction in an attempt to improve the condition of the cervix. Two groups of 15 patients were studied, one receiving prostaglandin E2 250 mug suspended in methyl ethyl cellulose ('Tylose') 6% solution, and the other tylose alone. Cervical status did not change in those receiving tylose alone, whereas a significant improvement occurred in 14 out of 15 patients receiving the prostaglandin. Labour began before formal induction in 1 patient receiving tylose and in 8 receiving prostaglandin.

Adolescent↗

Labour induction using buccal prostaglandin e2.

Prostaglandins may remain in the circulation for some two hours after oral therapy and any resultant hypertonus may be difficult to treat in these circumstances. Buccal administration based on the concept that tablets could be discarded should this occur, has been evaluated in 30 patients. Effective uterine stimulation occurred in 90% of subjects receiving a dose of 1mg hourly. No hypertonus occurred but two patients had a prolonged contraction on a single occasion during labour. The fact that the tablets dissolve rapidly and in addition produce an unpleasant buccal prostaglandins do not have advantages over alternative methods of oxytocic administration.

Adult↗

Buccal prostaglandin E2 for induction of labour.

The administration of buccal prostaglandin E2 (PGE2) was evaluated in 30 patients; effective uterine stimulation occurred in 90 per cent of those receiving a dose of 1 mg hourly. Two patients had a prolonged contraction on a single occasion during labour. The unpleasant taste of the tablets and a high incidence of nausea and vomiting indicated that buccal prostaglandins had no advantages over other methods of administering oxytocic agents.

Administration, Oral↗

Active pre-term management of severe osteogenesis imperfecta.

Some of the advantages of using an intra-amniotic injection of urea combined with prostaglandins for mid trimester termination include an extremely high success rate, a mean time of approximately 10 hours and delivery of a dead fetus. The successful application of this method for the active pre-term management of patients in whom severe fetal abnormality, such as that reported here, suggests this technique of inducing abortion and labour deserves further consideration in those special circumstances where the obstetrician is anxious that the pregnancy should be interrupted despite the gestation length and where a live birth should not occur.

Abortion, Induced↗

Hysteroscopy.

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Endoscopy↗

Intra-amniotic urea and low-dose prostaglandin E2 for midtrimester termination.

The efficacy and morbidity of injecting a standard dose of urea (80 g.) and a lower dose of prostaglandin E2 (P.G.E2) (2-5 MG) than that used previously have been assesed in 110 patients. All aborted--in a mean time of 10 hours 41 minutes. The average inpatient stay was 3-3 days. 5 patients (4-5%) had a cervical laceration.

Abortifacient Agents↗