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Biomedical subjects

I Cojocaru

Publications and source records attributed to I Cojocaru.

33 records · Page 2Linked to original sources
PubMedDate not supplied

[Dermatologic preparations with erythromycin--the correlation of the pharmaceutical form-therapeutic effect].

Erythromycin associated with progesterone and A vitamin has been included in three dermatological pharmaceutical forms: a lotion, a L/H emulsion and a L/H nonionogenic ointment. Aspect of these preparations has been noticed for a 90 days period. pH and electrical conductance were also determined during this interval. All the formulations mentioned above revealed insignificant variations of these parameters proving an appreciable physico-chemical stability. Clinical investigative studies in juvenile acne, showed efficiency, particularly for the emulsion form.

Anti-Bacterial Agents↗
PubMedDate not supplied

Oral lyophilizate--an alternative for products with low-soluble drugs.

The propyphenazone, a drug with pronounced anti-inflammatory, anti-fever, analgesic properties, is recommended in acute situations which require therapeutic blood levels in short time after administration. The review presented has the purpose of obtaining an oral lyophilizate, compared with the common tablets. Also, the specific parameters for oral solid dosage forms were determined. The procedure for the oral lyophilizate's preparation promotes the liquid form's mobility and activity, being designed as a solid product which disperses readily in small quantities of water. The presence of a solubilizing agent, included in formulation, will increase propyphenazone's dissolution and so, the analgesic, antiinflammatory effect will appear rapidly. The lyophilization of the selected formulation with a usifroid apparatus was conducted following the classic steps. The tablets were compared with compressed tablets having the same content in propyphenazone (0,250 g), being observed concerning the aspect, the diameter, the dissolution time and the percentage of dissolved substance in one hour. In comparison with compressed tablets, the substances associated in oral lyophilizate and the specific lyophilization technique determine propyphenazone's release in a shorter time interval.

Administration, Oral↗
PubMedDate not supplied

[The quality assessment of a product with adhesive properties for complete dental prostheses].

A formula of dental adhesive using as an agent responsible for this activity an indigenous product, C.M.C.Na 1080, gelified with preservative solution with added astringent agents was elaborated. The possible interaction between the constituents during preservation and the product qualities by determining the pH, extensibility index, sliding limit tension, antimicrobial activity and certain clinical aspects were evaluated.

Adhesives↗
PubMedDate not supplied

[The production of tablets with diethylaminoethanol p-acetylaminobenzoate].

A formulation for tablets with diethylaminoethanol p-acetylaminobenzoate was set. The obtained tablets are adequate from the point of view of organoleptic qualities, mean weight weight variations, mechanical strength and disaggregation, both after processing and one year storage. The kinetics of water and artificial gastric juice, determined with the help of a Nogami device, by tablets capillarity reveals a homogeneous porosity, fact that determines the complete disintegration of the tablets in due time, and thus a good availability.

Absorption↗
PubMedDate not supplied

[Sensitivity to chemotherapeutic agents of bacteria isolated from generalized infections].

A study carried out on 206 bacteriemia infections showed that: the following bacterial flora was implicated in the etiology of bacteremia infections: Staphylococcus aureus in 28.6% of cases, Staphylococcus albus in 20.4% Enterobacteriaceae in 25.7% and Pseudomonas in 3.8%; an increase existed in the number of generalized infections caused by opportunists belonging to the Enterobacteriaceae family and Pseudomonas genus. Similarly, an increase in the resistance to the recently introduced antibiotics, Septrin and Gentamycin, was noted. These observation require antibiotic lebel control and, if it is necessary the association of two or more antibiotics in severe infections.

Anti-Bacterial Agents↗
PubMedDate not supplied

[The pharmacotechnical assessment of the types of sodium carboxymethylcellulose of Romanian origin (its synthetic appearance)].

Three indigenous varieties of sodium carboxymethylcellulose, types 1,000, 6,000 and 10,000, with properties comparable to those of similar imported products were investigated in view of determining their qualities of excipients for some pharmaceutical products. Thus, they were used for obtaining a potassium chloride containing syrup, buvable ampoules with diethylaminoethanol N-acetylglutamate. Ointment bases and tablets with favorable qualities were also obtained.

Animals↗
PubMedDate not supplied

[Research to achieve a homeopathic lotion].

A formulation of homeopathic lotion was elaborated. It uses as mother-solutions: the Calendula tincture and the Fumaria tincture prepared according to the homeopathic rules, and a vegetal soft extract conventionally named by us Pt2a, and the 42 C alcohol was used as a vehicle. All dilutions were made at 3CH. The pH, the refraction index and the electrical conductivity of the three solutions prove a good stability of the preparation. The 2 CH a dilution was well tolerated at the administration with juvenile acne and the simple dry phthiriasis, an improving being noted after 3-4 days of treatment.

Acne Vulgaris↗
PubMedDate not supplied

Clinical manifestations in the West Nile virus outbreak.

During the summer of 1996 an unusual clustering of meningoencephalitis cases was recorded in the Capital City, Bucharest, and in some areas from South-East Romania. After an initial suspicion of an enteroviral etiology was discarded, the West Nile etiology was confirmed by specific antibodies demonstration through hemagglutination-inhibition and ELISA tests. This study included 251 patients with the diagnoses of West Nile acute encephalitis (166 cases), acute meningitis (57 cases) and acute febrile disease (33 cases). The patients' age ranged from 1 to 89 years (mean 51.1 years). The most frequent clinical manifestations were: fever (95.7% of cases), cephalalgia (92.6%), stiffness of the neck (89.1%), vomiting (62.5%), marked asthenia (46.5%), myalgia (28.9%). In addition, patients with encephalitis exhibited: alteration of consciousness (89.2% of cases), tremor of extremities (40.4%), ataxia (44%), paralysis (15.1%). The fatality rate was 15.1% in acute encephalitis, 1.8% in acute meningitis and 0% in the acute febrile disease.

Adult↗