Search PubMed⌕ Search

Biomedical subjects

I Claiciu

Publications and source records attributed to I Claiciu.

8 recordsLinked to original sources
PubMedDate not supplied

[Adenitis following BCG vaccination].

The authors present a study on 167 cases of post-vaccinal adenitis after B.C.G. administration. These occured after the experimental application in 1,187 newborns of two vaccines produced by different laboratories. Manifest adenitis developed only after the application of the vaccine with a higher virulence and a significant concentration of live germs (A), while the vaccine with a low concentration of live germs only determined inflammatory adenitis (vaccine B). In the cases when vaccine A was applied, both after intra-dermal introduction of a 0,10 mg dose or of a 0,05 mg dose, it determined adenitis with a long evolution and in 7,79 percent, respectively in 6,95 percent of the vaccinated children fistulization occured. In most of the cases adenitis developed in the first 6 months following vaccination (86,77 percent) but in some cases it appeared even after 1-2 years. In 78,3 percent of the cases adenitis had a long course and in only 21,7 percent they regressed rapidly. Adenitis did not involve the general condition of the children but determined a concern of the parents. The duration of evolution of adenitis was, as a general rule, of several months, or 1-2 years and even longer and the treatment with tuberculostatics (INH) did not significantly alter their evolution. When there was a tendency to the formation of abscesses, especially in the case of gigantic adenitis, a reduction of the duration of the evolution was obtained by puncture, and especially by lymph-node curettage. The intensity of the post-vaccinal allergy is noted in cases complicated by adenitis (100 percent), as well as its long persistance, while in non-complicated cases the allergy diminished each year both in intensity and frequency. The authors recommend that before the mass use of a vaccine this should be tested, especially in young children, in view of making the correct choice of the efficient dose, with a maximal efficiency and the lowest number of complications.

Abscess↗
PubMedDate not supplied

[Comparative immediate results after the use of several lyophilized BCG vaccines].

A number of 1928 children were vaccinated intradermally with 12 series of BCG vaccine produced by the Cantacuzino Institute and 2 experimental vaccines, prepared in the same laboratory by the same current technique, i.e. a Romanian strain and a French strain, lot 1173 P2. With the experimental vaccines 2 doses were used, with the other vaccines a single standard dose of 0.10 mg. Appraisal of tuberculin sensitivity 8-10 weeks after vaccination showed differences in tuberculin duration, varying between 13.23 mm and 16.27 mm in diameter with the selected vaccines (using 2 units PPD) and were much smaller (8.6 mm -- 12.28 mm) with the operational series of vaccines.

Adolescent↗
PubMedDate not supplied

[Tuberculosis].

Explore the source record for details and available documents.

Humans↗