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Biomedical subjects

I Chanarin

Publications and source records attributed to I Chanarin.

At least 145 records · Page 8Linked to original sources
PubMed1974

Cell-mediated immunity to intrinsic factor in autoimmune disorders.

Evidence of cell-mediated immunity to gastric intrinsic factor was present in 86% of patients with pernicious anaemia and in at least 13% of patients with hyperthyroidism, 21% of patients with atrophic gastritis, and four out of nine (46%) patients with hypogammaglobulinaemia. Controls gave negative results. The four patients with hypogammaglobulinaemia and cell-mediated immunity to intrinsic factor had evidence of impaired gastric function.

Agammaglobulinemia↗
PubMed1973

Formylation of folate as step in physiological folate absorption.

Oral administration of folate analogues to rats is followed by a rise in plasma folate detectable only by micro-biological assay with Lactobacillus casei, suggesting methylation of folate during absorption. When using the everted rat gut technique with folate (PteGlu), dihydrofolate (H(2)PteGlu), or tetrahydrofolate (H(4)PteGlu) on the mucosal surface formyl folate (10-CHO-PteGlu, 10-CHO-H(4)PteGlu, 5-CHO-H(4)PteGlu) and methylfolate (5-CH(3)-H(4)PteGlu) are recovered from the serosal fluid. This indicates that absorption of PteGlu is followed by formylation and that the formyl group is further reduced to methyl, 5-CH(3)-H(4)PteGlu passing on to portal blood.

Animals↗