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Biomedical subjects

I Cerveri

Publications and source records attributed to I Cerveri.

24 records · Page 2Linked to original sources
PubMed1985

Acute effect of indenolol on human airways.

Airways resistance and expiratory flow have been investigated in 6 healthy volunteers given single doses of indenolol, propranolol, atenolol and placebo in a randomized, double-blind, cross over study. The three active drugs significantly decreased the effort-induced rise in systolic pressure, and they also reduced the resting heart rate. The relative potency against exercise-tachicardia was propranolol greater than atenolol greater than indenolol. The double and triple product were significantly decreased, too, without any difference between the active treatments. After placebo or indenolol, an exercise-induced increase in the forced expiratory flow at low pulmonary volumes (MEF50 and MEF75) was observed. The two control beta-blockers caused a fall in exercise expiratory flow as compared to the resting values. The noncardioselective agent (propranolol) was more effective than the cardioselective compound (atenolol) in decreasing the expiratory flow. The mechanism of action of indenolol is discussed in the light of the lack of its acute effect on airways resistance.

Adolescent↗
PubMed1980

A comparison between different methods for detecting bronchial hyperreactivity. Bronchial hyperreactivity: methods of study.

The authors evaluated bronchial hyperreactivity comparing two different methods for aspecific bronchostimulation (H2O ultrasonic mist and free running) and a bronchodilation test. The investigation had been carried out on three groups of subjects. The first included 15 nonsmoking normal subjects, the second 23 asthmatic patients and the third 16 rhinitic patients. All subjects were submitted to bronchodynamic tests in three different ways. The ventilatory parameters were FVC, FEV1, MMEF and Vmax25. In normal subjects no significant changes were found. In asthmatic patients the bronchodilation test was positive in 65% of the cases, regarding FEV1 and in 87% regarding the forced flows. The running test was positive in 26% of the cases (FEV1) and in 61% of the cases (forced flows). The ultrasonic mist caused a significant drop in FEV1 in 17% of the cases, while flows were significantly reduced in 30% of the cases. In rhinitic patients the bronchodilation test was positive in 25% of the cases both considering FEV1 and forced expiratory flows. Ultrasonic mist never induced a decrease of FEV1, while flows decreased in 12.5% of the cases. The free running test was positive in 12% of the cases regarding FEV1 and in 25% regarding forced flows.

Adolescent↗
PubMedDate not supplied

[Cigarette smoke and bronchial hypersensitivity].

Among intrinsic factors which may affect the onset of COPD, bronchial non specific hyperresponsiveness seems to play an important, even though, ill-defined role. Attention is drawn to 2 major points: 1) Cigarette smoking habit may increase airway responsiveness? 2) Any possible hyperresponsiveness induced by smoking may be relevant in the development of COPD? At present, only point 1 may be positively answered; point 2 will be clarified by means of perspective and long-term surveys, we have not achieved yet. Our cross-sectional study showed a significant influence of smoking on bronchial responsiveness in absolutely asymptomatic subjects and with airway caliber absolutely in the normal range. This kind of influence resulted to be dose-dependent. Furthermore a noxious role of smoking has been observed, the greater effect the higher amount of cigarettes/day smoked. Moreover this acute role of smoking has been remarked by the trend of bronchial responsiveness of past-smokers, the more similar to non smoker's, the more far was smoking cessation.

Humans↗