Biomedical subjects
Publications and source records attributed to I Cavill.
The platelet count was measured at approximately monthly intervals during the course of 44 normal pregnancies. There was no evidence of any fall in the platelet count during pregnancy. Any significant change in the platelet count in pregnant women is unlikely to be the result of a normal pregnancy.
Serum ferritin concentration has been measured during the course of pregnancy in 154 women. There was a rapid decrease in iron stores during early pregnancy irrespective of any iron therapy. Oral iron did, however, prevent the stores reaching iron deficient levels during the second half of pregnancy. The results suggest that maternal erythroid activity starts early in pregnancy and may exhaust the iron stores before the fetal demands for iron can be met.
Ferrokinetic studies have fallen somewhat out of fashion and this is probably because T 1/2, PIT and percentage utilization give a poor reflection of the state of erythropoiesis. Recent advances have, however, enabled total, effective and ineffective erythropoiesis to be measured. The technique is simple but time-consuming, and analysis of the data requires access to computing facilities. Nevertheless, when bone marrow erythroid activity must be assessed these radioiron methods offer a rational approach.
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Existing ferrokinetic methods do not provide a direct and quantitative measurement of effective and ineffective red cell production. A new method is described for calculating the daily uptake of iron by maturing red cells and the mean red cell lifespan. Ineffective erythropoiesis and non-erythroid iron turnover are also measured. The method involves standard laboratory techniques but the analysis requires access to a computer. The preliminary results suggest that it will be a clinically useful tool for the investigation of erythroid disorders.
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The data processing problems which arise in the provision of a modern haematology service are discussed in the light of available resources, and the basic requirements of any automated data processing system are defined. The differences between the needs of haematology and those of other pathology specialities are emphasized. A strategy for the development of a simple system which covers data capture, analysis, and retrieval is described. Separation of the short-and long-term functions of the system provides a relatively simple, inexpensive solution which can be modulated to meet the particular circumstances of each laboratory.
Two simple methods of using sophisticated statistical techniques to analyse intralaboratory quality control data are described. One method uses a plastic grid to assess the cumulative sum (cusum) graph. An equivalent procedure, which may be carried out by a laboratory computer, gives automated on-line quality control of the Coulter S blood counter. The possible development of simple apparatus to carry out the same function is discussed.
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Serum labelled with (59)Fe for ferrokinetic studies should contain only [(59)Fe] transferrin. [(59)Fe] ferric citrate was incubated at 37 degrees C for up to 24 hours with sera having an excess latent iron-binding capacity. The results showed that unbound [(59)Fe] ferric citrate may be present for several hours. An anion exchange resin (IRA 400 Cl(-)) column removed all the [(59)Fe] ferric citrate and left only [(59)Fe] transferrin in the eluate. It is suggested that all (59)Fe-labelled preparations for ferrokinetic studies should be passed through a resin column before injection.
Leucocyte ascorbic acid concentration declines with age. Patients with iron-deficiency anaemia have higher concentrations than normal while those with iron overload have a reduced concentration. It is suggested that these phenomena may be a result of reduced ascorbate catabolism in iron-deficiency anaemia and they provide support for the suggestion that the amount of iron in the tissues may be an important factor in determining ascorbic acid utilization.