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Biomedical subjects

I C Roddie

Publications and source records attributed to I C Roddie.

At least 55 records · Page 3Linked to original sources
PubMed1973

The effect of -adrenoceptor blockade on human sweating.

1. Changes in cutaneous water loss were followed by continuously monitoring total body weight loss.2. Sweating was induced in normal subjects by raising the environmental temperature or by subjecting them to the emotional stress of mental arithmetic.3. Propranolol in a dosage of 0.15 mg/kg body weight intravenously had no significant effect on either thermal or emotional sweating, whereas thermal sweating was completely blocked temporarily by administration of atropine 2.4 mg intravenously.4. It is concluded that beta-adrenoceptor blockade has no effect on physiological sweating in normal people.

Adrenergic beta-Antagonists↗
PubMed1973

Spontaneous activity in isolated bovine mesenteric lymphatics.

1. Longitudinal tension was measured in isolated segments (approximately 20 mm in length and 2 mm in diameter) of bovine mesenteric lymphatic vessels.2. Seventeen out of thirty-nine vessels showed regular spontaneous rhythmic contractions, the most common frequency being about 2/min.3. The strength of each contraction was related to the duration of the preceding pause, a longer pause being associated with a stronger contraction.4. Noradrenaline increased the frequency and decreased the amplitude of the contractions. This effect was abolished by alpha-receptor blockade with phentolamine.5. Isoprenaline slowed the frequency of the contractions. This effect was abolished by beta-receptor blockade with propranolol.6. Acetylcholine had little effect on the rate of spontaneous contractions.

Acetylcholine↗
PubMed1973

The effect of a water load on cutaneous water loss in man.

1. Ingestion of 1 l. water at 37 degrees C had no effect on the rate of water loss from forearm and hand skin although ingestion of a similar volume at 16 degrees C significantly decreased the rate.2. Ingestion of 1 l. water at 37 degrees C had no physiologically significant effect on the expiratory minute volume.3. Ingestion of 500 ml. water at 37 degrees C caused small increases in total body weight loss in environmental temperatures of 29 and 40 degrees C.4. It is concluded that neither cutaneous nor respiratory water loss play an important part in the excretion of a water load in man.

Adult↗
PubMed1973

The effect of pain on human sweating.

1. Attempts were made to induce emotional sweating in normal subjects by subjecting them to painful stimuli such as compression of pins on the forearm skin, immersion of the fingers in iced water, compression of the thoracic cage by rib calipers and ischaemic exercise of the forearm muscles.2. Changes in sweating were estimated by continuously monitoring the rate of total body weight loss.3. Of the painful stimuli used, only ischaemic forearm exercise significantly increased the rate of sweat secretion.4. Tasks in mental arithmetic caused much greater increases in sweat secretion than any of the pain stimuli except ischaemic pain.5. It is concluded that many varieties of pain, even when severe, do not induce sweating under laboratory conditions.

Body Weight↗
PubMed1973

The regional distribution of emotional sweating in man.

1. Emotional sweating was induced in normal subjects by mental arithmetic at environmental temperatures of 29 and 26 degrees C and estimated from continuous records of body weight loss.2. The sweat output from four independent regions of the body - (a) the head and neck, (b) the arms and legs, (c) the trunk, and (d) the hands and feet - was studied separately, the remainder of the body being covered in each case by plastic bags. The evaporative water loss from each skin region increased markedly during mental arithmetic.3. The sweat contribution from each region was a substantial fraction of the total body sweat response and appeared to be roughly proportional to the calculated number of sweat glands in each region.4. There is no evidence from these experiments to indicate that the sweat glands of the skin of the hands and feet behave differently to those of the skin of the rest of the body in response to emotional stress.

Adult↗
PubMed1972

The role of circulating catecholamines in sweat production in man.

1. The effects of intravenous infusions of adrenaline, isoprenaline and noradrenaline on human sweating were assessed by continuous measurement of total body weight loss in normal subjects.2. All three catecholamines increased the rate of weight loss but isoprenaline was effective in a much smaller dosage than either adrenaline or noradrenaline.3. beta-adrenoceptor blockade with propranolol reduced the response.4. The response was not abolished by collecting expired air in a Douglas bag suggesting that it was not due to an increase in respiratory water loss.5. The response was not abolished by atropine infusions suggesting that it was not mediated through cholinergic sudomotor nerves.6. It is concluded that intravenous infusions of catecholamines may elicit a small, non-cholinergically mediated sweat response in man.

Adult↗