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Biomedical subjects

I C Paterson

Publications and source records attributed to I C Paterson.

At least 19 recordsLinked to original sources
PubMed1991

The influence of breast size on late radiation reaction following excision and radiotherapy for early breast cancer.

The correlation between late radiation reaction and brassiere size (bust and cup size) in 133 patients with T1 and T2 breast cancer treated by excision and radiotherapy was examined. The radiotherapy schedule used was 4875 cGy in 15 x 3.25 Gy fractions over 39 days treating five times per fortnight. Patients were followed up to a minimum of 2 years (median 4.2 years). The incidence of unacceptable late radiation reaction rose significantly with bust size (P less than 0.001) and cup size (P less than 0.02). It is intended to treat ladies with large breasts with a reduced fraction size or on a daily basis.

Breast↗
PubMed1991

The treatment of squamous cell carcinoma of the paranasal sinuses.

Of 72 cases of paranasal sinus malignancy that were identified, 47 were biopsy proven squamous cell carcinomas. Actuarial analysis of these patients receiving both radical and palliative treatment revealed an overall 5-year survival of 37.4%, and a relapse-free survival of 31.6%. For patients receiving radical treatments (i.e. radiotherapy alone, or preoperative radiotherapy followed by elective surgery), the 5-year survival results were identical (46%). In this series radiotherapy alone is an effective treatment, and subsequent planned surgery did not improve the survival.

Adult↗
PubMed1988

Response rates and survival in patients with head and neck cancer treated with a combination of cisplatin and 5-fluorouracil prior to radiotherapy.

Fifty-three previously untreated patients with advanced head and neck cancer were given courses of cisplatin and 5-fluorouracil prior to radical radiotherapy. The overall response rate to chemotherapy alone was 66% but only two cases achieved a complete response. After radiotherapy, 62% were in complete remission but there was no evidence for improved overall survival when compared to historical data. Patients who responded to chemotherapy had a significantly better chance of achieving a complete remission after radiotherapy, and had a significantly improved survival when compared to non responders to chemotherapy, including those whose disease disappeared after radiotherapy. The survival data compare favourably with other series claiming higher complete and partial responses to the same combination of drugs.

Adolescent↗
PubMed1987

Nasopharyngeal carcinoma: a review of cases treated by radiotherapy and chemotherapy.

Between 1965 and 1983, 52 cases of carcinoma of the nasopharynx were treated with radiotherapy alone and 14 treated with combination chemotherapy containing cisplatin followed by a radical course of radiation. Before 1981 all cases were treated by radiotherapy alone with a variety of dose and fractionation regimes. The actuarial overall 3 year survival for these cases was 35%. Twelve of the 14 (86%) who received chemotherapy responded, and in two there was complete disappearance of disease before the radiotherapy. The 3 year survival for those receiving chemotherapy and radiotherapy was 86%. The possible reasons for this apparent improvement are discussed.

Adolescent↗
PubMed1985

Cisplatin-containing chemotherapy in advanced head and neck cancer.

Sixty-two patients with previously untreated advanced head and neck cancer were admitted to a study of pre-radiotherapy combination chemotherapy containing cisplatin. After two courses only 3% were in complete response but 47% had achieved a partial response. Ninety per cent of patients completed radical radiotherapy and at least one course of chemotherapy; 54% of these achieved a complete response at 1 month post-therapy. The overall actuarial survival rate at 2 years was 40.3%, with a median survival of 12 months. The median survival of those with complete response 1 month after therapy has not yet been reached. The toxicity of the chemotherapy was low and no increase in morbidity from the subsequent radiotherapy was noted. Comparison with historical data from this hospital does not suggest any improvement in overall survival for the use of cisplatin-containing chemotherapy prior to radiotherapy.

Adult↗
PubMed1978

Cancer-specific density changes in lymphocytes after stimulation with phytohaemagglutinin.

A fluorescence polarisation technique ("S.C.M. test") for detecting responses to phytohaemagglutinin revealed that the responsive lymphocytes from patients with malignant disease had an abnormal distribution after centrifugation through lymphocyte separation medium. In a small blind series the technique accurately distinguished patients with histologically proven malignancies from those with nonmalignant disease and normal people.

Adenocarcinoma↗
PubMed1977

Asthmatic pulmonary eosinophilia: a review of 65 cases.

In a series of 65 patients with asthma with pulmonary eosinophilia 54 were adequately investigated for allergic aspergillosis and this was present in 32 (59%). Asthma with pulmonary eosinophilia was found to carry a relatively poor prognosis in terms of permanent symptoms, impairment of pulmonary function and residual radiographic abnormality. The prognosis was least favourable when allergic aspergillosis was associated with long-standing asthma. On the other hand there was a group of patients with asthma with pulmonary eosinophilia who had relatively little permanent disability. These were mainly women with asthma of recent onset, and in these evidence of allergy to Aspergillus fumigatus was less apparent. Those patients who received long-term daily corticosteroid therapy were less likely to develop further radiographic opacities than those given intermittent corticosteroid therapy. To prevent recurrent pulmonary infiltrates it is probably necessary to give prednisolone in a daily dosage of at least 10 mg for an indefinite period.

Adolescent↗
PubMed1977

Further studies of rimiterol and salbutamol administered by intermittent positive-pressure ventilation, and an important observation on the technique of using the Bennett ventilator.

1. Using the same technique of administering drugs by intermittent positive-pressure ventilation as used in previous studies a source of contamination of solutions nebulized was discovered. This was rectified by using a new ventilator and completely separate patient circuits for each solution nebulized. 2 Salbutamol 0.5% and 0.25% solutions achieved the same degree of bronchodilatation, but there was a significantly greater increase in heart rate produced by salbutamol 0.5%. 3 Rimiterol 0.5% and salbutamol 0.25% produced similar peak mean improvements in FEV and also induced the same degree of tachycardia, but the duration of these effects were significantly shorter in the case of rimiterol. 4 The sustained degree of bronchodilatation achieved by salbutamol 0.25% could not be mirrored by giving two doses of rimiterol 0.5%, the second dose 2 h after the first. 5 Rimiterol 0.5% induced a degree of tachycardia which was similar in peak effect to that observed after salbutamol 0.25%. However, in the controls the second dose of rimiterol, given 2 h after the first, was responsible for only a small increase in heart rate which was not significantly different than that after saline in the other three treatment groups.

Adult↗