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Biomedical subjects

I Bragiel

Publications and source records attributed to I Bragiel.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Comparative studies of human and animal sera containin g anti-HB-8 antibodies].

In a material of 768 sera obtained from blood donors and patients and 150 sera containing HBs antigen it was investigated whether the available animal sera (horse, swine, goat) with anti-HBs antibodies meet the requirements of diagnostic sera. It was found that none of these anti-HBs animal sera was better than the human serum used as yet. Only the specificity of horse anti-HBs antibodies was equal to the human serum, hence horse serum could be used for diagnostic purposes in routine investigations by the precipitation and complement fixation method. The swine and goat sera did not ensure detection of all HBs antigens which are detected using human or horse serum.

Animals↗
PubMedDate not supplied

[Immunochemical and biological properties of rapid monoclonal proteins of the IgG class].

Four proteins M class IgG were analysed in detail in view of their more rapid electrophoretic migration in starch gel among most proteins in this class. On the basis of these investigations two protein (from sera 212 and 244) corresponded to subclass IgG-4, one (serum 119) probably to IgG-4 with polyclonal impurities from other subclasses, and the fourth protein (from serum 210) to subclass 3 or 1. Since subclass IgG-4 contains the greatest amount of sialic acid residues of the remaining IgG subclasses finding of more rapid migration of the observed proteins seems to be due to this. A hypothesis has been put forward that if rapidly moving IgG do not belong to subclass 4 then they have, probably, atypically arranged carbohydrate groups, e.g. in Fab fragment. It was found also that the studied proteins M were carried during chromatography with DEAE cellulose only when a buffer with higher concentration of NaCl was used.

Electrophoresis, Paper↗
PubMedDate not supplied

[Autoimmune hemolytic anemia with presence of 3 types of autoantibodies to erythrocytes].

In a patient with chronic lymphatic leukaemia severe autoimmunohaemolytic anaemia (NAIH) was observed with coexistence of cold incomplete IgM, warm incomplete IgG and warm haemolysins active against papainized erythrocytes in low pH medium. The serologic and immunochemical characteristics of autoantibodies are presented and the mechanism of their action in vitro is tentatively explained.

Anemia, Hemolytic, Autoimmune↗