Biomedical subjects

I Ben-Nun

Publications and source records attributed to I Ben-Nun.

40 records · Page 3Linked to original sources

PubMed1980

Danazol in the treatment of mammary dysplasia.

While employing danazol in the management of women with endometriosis, a voluntary comment patients frequently offerd was that breast pain, nodularity and premenstrual engorgement were alleviated. Because of this unexpected finding, our attention was directed to the treatment of women with mammary dysplasia, particularly fibrocystic disease of the breast. Since the incidence of mammary cancer increases rapidly with age, we obtained xerommamograms in all suspected cases to exclude such a possibility. Danazol was employed in dosages varying from 100 to 400mg per day for 3 to 6 months, depending on the severity of the disorder. More than 75% of patients experienced marked improvement or elimination of the nodularity and engorgement, and many women were spared unnecessary surgery. When surgical interference was deemed necessary in cases of multiple nodosities, danazol treatment helped to identify for biopsy a dominant nodule that did not respond to therapy. Danazol has much to offer in the treatment of benign breast disease, and represents an important advance over 'traditional' hormonal regimens proposed in the past.

Breast Diseases↗

PubMed1980

Separation of human spermatozoa from a single ejaculate into various age-groups.

Ejaculated human spermatozoa were separated into various age-groups on the basis of their different specific gravity. Salt-poor 25% human serum albumin was used as a separation medium. The separation process had no detectable harmful effect on the spermatozoa. The motility and penetration abilities of the separated cell fractions were tested by means of a new method using a fragiligraph. The younger group of spermatozoa demonstrated better motility and penetration ability in comparison with the older age-groups.

Adult↗

PubMed1980

The treatment of benign breast disease with danazol.

Benign breast disease, aside from fibroadenomas and intraductal papillomas, frequently responds favorably to hormonal therapy. Although the use of estrogen, androgens, and progestogens often proves useful, danazol, in our hands, was found more consistently effective. Danazol, an impeded androgen derived from a progestogen, 17 alpha-ethinyltestosterone, was employed in doses of 100 to 400 mg/day for 3 to 6 months in the treatment of fibrocystic disease. This agent proved efficacious in eliminating nodularity in the majority of cases, with partial resolution in most of the others. Many women to whom surgery had been previously suggested were spared surgical interference because of a satisfactory response to danazol therapy.

Adult↗

PubMedDate not supplied

Growth hormone--non multum sed multa (quality, not quantity).

In view of the recent availability of recombinant human growth hormone (GH) and reports of its ability to augment ovulation induction by exogenous gonadotropins, we have surveyed the reproductive physiological role of GH and the family of polypeptides that mediate its action. The clinical studies using GH to improve ovulation induction, although achieving a significant reduction in exogenous gonadotropin administration, show only minor benefits in terms of attainment of pregnancy. An explanation for this phenomenon is suggested, and we provide guidelines for whom GH should be recommended.

Animals↗