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Biomedical subjects

I Baumann

Publications and source records attributed to I Baumann.

At least 73 records · Page 4Linked to original sources
PubMed1986

Leukemia-related morphological features in blast cells.

This paper investigates the use of image-processing methods to detect leukemia-related morphological differences in mononuclear blast cells. Routinely prepared Pappenheim-stained blood smears were scanned in a high-resolution color TV-microscope system. Eleven blast-cell classes (OMSBC, T-ALL, OMS, ALL, LBL, IBL, AUL, AML, AMOL, AMMOL, and CML) were analyzed with the nonparametric statistical software program "Classification and Regression Trees" (CART). This paper documents the initial statistical evaluation of 62 leukemia-related morphological features that directly measure and analyze the cell-related quantifiable differences occurring in the various blast cells. The 62 cell image features include both common cytophotometric features, and new texture and color features developed for this project. This study found that each leukemia specimen contains a dominant class of blasts that correlates with the specific leukemia, plus a distribution of blasts from related diseases. The present data suggest the existence of a distribution fingerprint pattern for each leukemia.

Cell Nucleus↗
PubMed1985

Interactions of a variety of lipoxygenase inhibitors with a supplementary binding site on soybean lipoxygenase.

Studies on the combined effects of a variety of lipoxygenase inhibitors and cyclo-oxygenase inhibitors revealed strong evidence for the existence of supplementary binding sites on lipoxygenases which modify the reactions of inhibitors with the catalytic site of the enzyme. Independent of their low or non-existent inhibitory reaction at the catalytic site, compounds which interact more effectively with this putative supplementary site are capable of blunting the inhibitory efficacy of potent lipoxygenase inhibitors. Although the degree of interaction with the catalytic site determines the potency of inhibitors, an additional reaction at the supplementary site is also obligatory for inhibitory efficacy. We found that potent lipoxygenase inhibitors possess high affinities for both sites, whereas weak inhibitors and suitable cyclo-oxygenase inhibitors interact predominantly with the supplementary site on the lipoxygenase and possess low or negligible affinities for its catalytic site.

Acetone↗
PubMed1984

Interactions of inhibitors of the lipoxygenase and cyclooxygenase pathways with a supplementary binding site on soybean lipoxygenase.

The oxygenation of [1-14C]-arachidonic acid by a soluble soybean lipoxygenase (E.C.1.13.11.12) preparation was determined in the presence of various cyclo-oxygenase and lipoxygenase inhibitors. The results showed that several non-inhibitory compounds drastically blunted the inhibitory potency of potent lipoxygenase inhibitors. Studies on the combined effects of a variety of structurally unrelated inhibitors of lipoxygenase, cyclo-oxygenase or both oxygenation pathways provided strong evidence for the existence of a supplementary binding site on soybean lipoxygenase which reduces the effective interactions of inhibitors with the catalytic site. Thus several cyclo-oxygenase inhibitors (which do not inhibit at the lipoxygenase catalytic site), as well as low concentrations of lipoxygenase inhibitors, interact with this putative supplementary site and blunt the inhibitory efficacy of potent lipoxygenase inhibitors. Although the degree of interaction with the catalytic site determines the absolute potency of inhibitors, the additional interaction at the putative supplementary binding site is also obligatory for inhibitory potency. In this new multiple-site model the potent lipoxygenase inhibitors (e.g. acetone phenylhydrazone, phenidone) possess high affinities for both sites, whereas weak inhibitors and certain cyclo-oxygenase inhibitors (e.g. benoxaprofen, phenylbutazone, indomethacin) interact predominantly with the supplementary site on the lipoxygenase but lack affinity for the catalytic site.

Binding Sites↗
PubMed1983

[Discontinuous plasma exchange with the conventional hemodialysis technic and blood cell centrifugation].

A conventional haemodialysis system, to which the patient is connected as for acute dialysis, forms the basis of the plasma substitution method. At each session around 2 litres of plasma were exchanges within 3 hours. Freshly frozen donor plasma was mainly used as the substitution solution. A total of 20 substitutions were carried out in 5 patients in a period of 7 months. The indications were: 3 x major mismatch in the ABO system before bone marrow transplantation, myasthenic crisis, violent attacks connected with lupus erythematosus with rapid development of renal insufficiency. The therapeutic goal of quickly eliminating immunopathogenetic proteins was achieved in all cases. It was possible to reduce the level of isoagglutinins, haemolysins, autoantibodies (myasthenia gravis) and immunity complexes (LE) effectively. The clinical course confirmed the excellent effectivity. There were no serious complications despite the serious primary diseases. Volume imbalances, changes of body temperature, precipitations of cryoglobulins, electrolyte disturbances or citrate intoxications were always well controllable thanks to the combination of plasma substitution and dialysis.

ABO Blood-Group System↗
PubMed1976

[Value and worthlessness of clinical studies in the diagnosis of brain death].

Death was ever determined on the basis of extinguished partial functions of the entire organism (partial death). In intensive medicine with its possibilities of reanimation, with its possibilities of artificial maintenance of breathing and circulation the individual death of man is equated with his cerebral death. It comes only under conditions of reanimation and nearly always shows a clinically recognizable development. Practically above all "the syndromes in the forefield of cerebral death" are of interest as well as its obligatory and optional symptoms, the valency of which was critically tested. A 5-year-analysis (1969 to 1973) of 487 deaths in an internal intensive therapy unit (18% of mortality) was shown that causes, frequency and age distribution of the mortal conditions of disease as well as the average survival time of 4.5 days, in which cases, however, 43% of all deaths occurred within the first 24 hours, very rarely caused us to establish the irreversibility of the loss of the cerebral function on account of an organic dysfunction, but rather resulting from the question of the interruption of an absurd reanimation.

Brain Death↗
PubMed1975

[Myasthenia gravis: surgical treatment with thymectomy (author's transl)].

Thymectomy may be an effective treatment of Myasthenia gravis. 25% of the 16 patients had a complete remission of the disease, 70% remarcable improvement. Half of the patients were able to resume working. Diagnostic methods, surgical and postoperative problems are discussed. Lateral left thoracotomy is recommended.

Adolescent↗