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Biomedical subjects

I B Angorn

Publications and source records attributed to I B Angorn.

At least 37 records · Page 2Linked to original sources
PubMed1981

Inhibition of mitogen-induced lymphocyte proliferation by autologous serum in oesophageal carcinoma.

The reactivity of lymphocytes from patients with oesophageal carcinoma in response to mitogenic stimulation with phytohaemagglutinin was assessed in four culture systems in an attempt to demonstrate an inhibitory effect of cancer serum on lymphocyte transformation. The metaphase index (number of cells at metaphase/1000 live cells) was used to determine lymphocyte reactivity of patients and controls in the presence of: (a) autologous plasma; (b) pooled AB serum; (c) pooled plasma from patients with oesophageal cancer, and (d) fetal calf serum. The division of lymphocytes from cancer patients was significantly depressed in the presence of autologous plasma (p<0,001) when compared with division of lymphocytes of control subjects. No significant difference was evident in pooled AB serum, homologous cancer plasma or fetal calf serum. The depressed lymphocyte reactivity in cancer patients appears to be related to a serum inhibitory factor.

Cells, Cultured↗
PubMed1980

Nutritional support in high-output fistulas of the alimentary tract.

A total of 63 patients with high-output alimentary tract fistules was treated during a 3-year period, using three different regimens of nutritional support. The fistula closed spontaneously in 46 patients (73%), and 7 patients (11%) were cured by direct surgical closure. Nine patients died, a mortality rate of 14.3%. The combination of nutritional support, skin protection, and timed surgical intervention can reduce the mortality rate to below 10%.

Adolescent↗
PubMed1979

Nutritional status and the nonspecific cellular and humoral immune response in esophageal carcinoma.

In carcinoma of the esophagus, two major factors are operative, both of which are capable of suppressing the immune response, namely starvation and the presence of a malignant tumor. Twenty patients who were treated by palliative intubation for unresectable carcinoma of the esophagus were investigated. All patients were suffering from protein-calorie malnutrition and were shown to be in negative nitrogen balance. Lymphocyte counts and the nonspecific cellular and humoral immune response were evaluated before and after correction of the nutritional deficit. No attempt was made to reduce tumor bulk. The cellular immune response was compromised in all patients. The DNCB skin test was negative, absolute lymphocyte counts and T-lymphocyte numbers were significantly depressed, and the mitogenic response to phytohaemagglutinin (PHA) stimulation also significantly depressed. Immunoglobulin A levels were significantly elevated but serum complement concentrations were normal. Reversal of the negative nitrogen balance resulted in a significant increase in absolute and T-lymphocyte numbers, and a significant increase in the mitogenic response to PHA. The DNCB skin test, however, remained nonreactive. Nutritional repletion also significantly increased serum C(3), C(4) and C(3)PA concentrations. Reversal of negative nitrogen balance may reverse in vitro evidence of immunoparesis and produce an increase in complement concentrations, without therapeutic reduction in the tumor load.

Body Weight↗
PubMed1979

Palliative pulsion intubation in oesophageal carcinoma.

Peroral pulsion intubation for the palliation of dysphagia due to oesophageal carcinoma was performed on 652 patients. The mortality was 16%, failure rate 3%, and hospital stay 3 days. Advanced disease and the presence of oesophagorespiratory fistula is not a contraindication to intubation.

Adult↗
PubMed1978

Traumatic diaphragmatic hernia.

A series of 58 cases of traumatic diaphragmatic hernia following blunt and penetrating injury is reviewed. The problems of radiodiagnosis are outlined and the need for barium contrast studies of the entire gastrointestinal tract to ensure recognition of isolated small bowel herniation is emphasized. Surgical access via laparotomy is recommended in the immediate post-traumatic presentation, whereas thoracotomy is preferable in cases diagnosed after a latent interval. Penetrating injury resulted in smaller diaphragmatic defects, greater morbidity and higher mortality due mainly to infective complications.

Adolescent↗
PubMed1978

Diminished cellular immunity due to impaired nutrition in oesophageal carcinoma.

The nutritional status of 15 Negro patients suffering from unresectable carcinoma of the midthoracic oesophagus was evaluated before and after palliative pulsion intubation. All were shown to be in negative nitrogen balance and to have a compromised non-specific cellular immune response. Correction of protein-calorie malnutrition and the achievement of positive nitrogen balance were associated with an increase in absolute lymphocyte and T lymphocyte numbers and a significant increase in lymphocyte response to PHA. The improvement in immunological reactivity occurred without any attempt at therapeutic reduction in tumour bulk.

Adult↗
PubMed1978

Colorectal carcinoma in young black patients: a report of eight cases.

Colorectal carcinoma in the black population of South Africa is very uncommon when compared with incidence among whites. Even in whites the proportion of patients with colorectal carcinoma under 25 years of age is less than 1% (Hardin, 1972). Eight cases of colorectal carcinoma in black patients under 25 years of age are presented. None had any evidence of premalignant lesions of the colon. The prognosis of colorectal carcinoma in young adults is poor in most series and this group of patients was no exception. Reasons for this poor prognosis are mentioned. A more aggressive approach to the early detection and treatment of the lesion in young patients is essential.

Adenocarcinoma, Mucinous↗
PubMed1978

Delayed presentation of traumatic diaphragmatic hernia.

Twenty-five patients with traumatic diaphragmatic hernia discovered at least five months after injury are described, of whom 18 were male and seven female. All but one hernia occurred on the left side. Stab wounds were the etiological factor in 22 patients and blunt trauma in three. The diagnosis was most often made by a chest or abdominal radiograph, but barium ingestion confirmed the diagnosis in ten patients. Intercostal drainage of gastric contents provided the diagnosis in two patients. In all nine patients initially approached by a thoracotomy or a thoracoabdominal incision, the hernia was easily reduced and the defect repaired. Although reduction and repair were easily accomplished by the abdominal route in seven patients, this approach was unsatisfactory or inadequate in six others. The colon and stomach were usually in the chest, and strangulation occurred in five patients. The mortality was 20% but rose to 80% when gangrene was present.

Adult↗
PubMed1977

Gastric volvulus unassociated with hiatal hernia.

Although para-oesophageal hiatal hernia is the commonest cause of gastric volvulus, other causes of gastric volvulus require emphasis and 16 cases of gastric volvulus unassociated with hiatal hernia are reported. Delayed presentation following diaphragmatic injury was common. It is recommended that a thoracolaparotomy be performed in these patients to facilitate reduction of the volvulus, and division of intrathoracic adhesions under direct vision. In the secondary type of gastric volvulus accurate diagnosis is mandatory. Failure to recognize and treat associated disease will result in recurrence of the volvulus. A rational approach to the management of gastric volvulus is proposed.

Acute Disease↗
PubMed1977

Traumatic haemobilia: case reports.

Injury to the liver may result in traumatic haemobilia. Three cases are reported, with differing clinical presentation resulting from different forms of injury. Haemobilia may present difficulties in diagnosis, particularly if there has been a long delay between injury and presentation. The use of selective hepatic arteriography as a diagnostic aid and treatment by hepatic artery ligation are outlined.

Adolescent↗
PubMed1977

Tumour metastasis to the thyroid gland.

Ten cases of tumour metastasis to the thyroid gland are reviewed. Thyroid involvement implies disseminated malignant disease, but metastatic tumours may simulate a primary thyroid tumour. It is suggested that thyroid involvement by metastasis is more common than previously assumed. Needle biopsy of the thyroid gland permits accurate histopathological diagnosis.

Adult↗