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Biomedical subjects

I Azancot

Publications and source records attributed to I Azancot.

At least 37 records · Page 2Linked to original sources
PubMed1981

Myocardial hypertrophy, rate of change of free wall thickness and directional components of ventricular power in man.

The diastolic (Vd) and systolic volumes, the average free wall diastolic thickness (hd) and left cardiac cavity pressures were determined in 25 subjects using monoplan angiography. Ten subjects presented a normal angiogram (NA), 5 a myocardiopathy with predominant dilatation (MCD), 4 a myocardiopathy with predominant non obstructive hypertrophy (MCH), and 6 a volume overload (VO). All the subjects had a normal coronary-cineangiogram. Myocardial volume (Vw) and systolic thickness were calculated from hd and from end-diastolic and end-systolic internal dimensions. The degree of myocardial hypertrophy was estimated from the value of Vw/Vd. The directional components of the total systolic elemental power due to thickening (average radial power : Pr) and to midwall circumferential shortening (average equatorial power : Pe) were calculated for each subject. Patients with NA, with MCD and with VO presented a positive linear correlation between Pr/Pe and Vw/Vd (r = 0.90). Patients with MCH were clearly below the regression line defined by the other groups. This relationship suggests that the contribution to the total power due to the thickening component is greater with increasing cardiac hypertrophy, except in the case of subjects showing an "inappropriate" hypertrophy.

Adult↗
PubMed1981

[Recurrent ventricular tachycardia due to right ventricular dysplasia. Association with left ventricular anomalies].

The authors report a case of arrhythmogenic right ventricular dysplasia in a 61year old male with a 9 year history of recurrent ventricular tachycardia with a left bundle branch block configuration and without any signs of cardiac failure. A right ventricular angiography showed morphological changes suggestive of Uhl's anomaly and left ventricular angiography showed segmental wall dysfunction. In the absence of coronary artery disease, this case raises the questions of left ventricular extension of right ventricular dysplasia and of the value of left ventricular angiography in adult forms of Uhl's anomaly.

Bundle-Branch Block↗
PubMed1980

[Angiographic frame-by-frame computerized evaluation of overall and regional left ventricular wall motion (author's transl)].

This paper describes a semi-automated quantitative method to evaluate left ventricular overall and regional wall motion. Left ventricular (LV) outlines are digitized on a frame-by-frame basis using a sonic graf/pen interfaced with a 9845 HP minicomputer. A high fidelity simultaneous LV pressure recording is also digitized. The overall myocardial pump and muscle function are expressed by the projections of the pressure-volume-flow and of the mid-wall equatorial stress-length-velocity relationships. The dynamic regional wall motion is quantitated using a radial coordinate method. The centers of mass of serial frames are superimposed, and the apical anti-clockwise rotation is corrected. The regional wall motion (RWM) and the rate of change of the RWM are calculated with this method, and the results plotted as a single hard copy output. This method permits evaluation of the effect of segmental wall dysfunction on total cardiac performance during different portions of the cardiac cycle. The relationships between the time course of LV pressure and stress and the dynamic RWM can also be studied in subjects with segmental contraction abnormalities.

Biomechanical Phenomena↗
PubMed1979

[Effects of the parenteral administration of trinitroglycerin on myocardial function, coronary flow and myocardial oxygen consumption in the coronary artery disease patient (author's transl)].

An angiographic study, combined with the determination of coronary flow (thermodilution) and of coronary arteriovenous difference was performed in 10 patients with coronary artery disease under basal conditions and following an infusion of trinitroglycerine. The following changes were noted under the influence of trinitroglycerine: significant fall in left ventricular telediastolic pressure (40%), telediastolic volume (18%), telediastolic strain (53%), mean aortic pressure (11%) and mean systolic strain (21%). Significant increase in ejection fraction (8%), mean shortening (Vcf: 22%) and thickening (Vep: 22%) rates. Significant fall in coronary flow (11%) without any change in coronary arteriovenous difference. Decrease in myocardial oxygen consumption parallel to the reduction in mean systolic strain. These results indicate that the essential mechanism of haemodynamic and metabolic action of trinitroglycerine is located at the level of "load", in particular "preload".

Adult↗
PubMed1979

Relationships between hemodynamic profiles and topography of acute myocardial infarction.

Initial hemodynamics were studied in 101 patients with acute myocardial infarction complicated by shock or left heart failure. 59 had anterior myocardial infarction (AMI); 42 had inferior myocardial infarction (IMI). Data were processed by univariate analysis and correspondence analysis. AMIs and IMIs were significantly different on conduction disturbances, heart rate, left ventricular filling pressure, mean pulmonary artery pressure and right ventricular function indices. Both patients and parameters were projected on the most meaningful factorial plane generated by correspondence analysis. This two-dimensional graphical representation showed that all the information was roughly distributed along the 2 orthogonal axes defining this plane. Survivors and nonsurvivors were fairly well separated along the first factorial axis (prognostic axis) which was highly correlated with both outcome and left ventricular function parameters. AMIs and IMIs were grossly separated along the second factorial axis (topographical axis) which was rather well correlated with location and right ventricular function parameters. These studies suggest that AMI and IMI hemodynamic profiles are modulated by the presence or absence of right ventricular dysfunction. Moreover right ventricular dysfunction may be held responsible of some lack of information about left ventricular function status.

Acute Disease↗
PubMed1978

[A simplified arteriographic analysis of systolic pressure and of the pressure-time index].

Systolic stress has been measured in 20 ms periods during ventricular ejection by monoplanar angiographic method, both under basal conditions and after infusion of trinitro-glycerine (TNG) in 8 coronary patients. None of them showed significant segmental contraction abnormality. No correlation was found between the corresponding values of mean systolic stress sigma and mean systolic pressure P, either under basal conditions (r=0.48) or after reduction of the load (r=0.24). On the other hand, values of sigma correlated closely with the corresponding values of the stress sigmas at the end of the isovolumic contraction phase, both under basal conditions (r=0.95) and after TNG (r=0.98. A similar correlation was found between the corresponding values of the peak of systolic stress and of sigmas both under basal conditions (r=0.94) and after TNG (r=0.96). Determination of sigmas is technically simple, and only requires the calculation of ventricular end-diastolic volume, together with measurement of end-diastolic thickness and aortic diastolic pressure. This simplified angiographic method is useful to express the determinants of myocardial energy using parietal stress values instead of intracavitary pressure values.

Angiography↗
PubMed1977

Hemodynamic evaluation of hypotension during chronic hemodialysis.

Hypotensive episodes occur frequently during hemodialysis; they are often sudden and difficult to prevent despite careful clinical control. Their etiology was studied by investigating the hemodynamic response of five patients submitted to ultrafiltration during their three first dialyses. A Swan Ganz catheter was inserted and left in position for 5 days. Simultaneous determination of cardiac output, mean pulmonary artery (PAP) and capillary and systemic arterial pressures were recorded. 10 hypotensive episodes were observed. In 3 patients in whom the first hypotensive episode occurred 10 minutes after the start of dialysis, there was a significant drop in PAP, cardiac index and stroke index while heart rate and peripheral resistance remained unchanged. Paradoxical bradycardia was observed. In 4 patients hypotension was observed more than one hour after initiation of dialysis. Before the hypotensive episode there was moderate elevation of heart rate and peripheral resistance and an insignificant reduction in PAP. Cardiac index and stroke index were diminished. The decrease in MAP was only 2 mm Hg. Hypovolemia is the most important factor in hemodialysis-induced hypotension but other factors such as vagal stimulation, autonomic neuropathy and osmotic disequilibrium can interfere with blood pressure control and trigger hypotension. Methods of preventing hypotension during dialysis, including the infusion of low molecular weight dextran, are discussed.

Adult↗
PubMed1974

[SHock states. 1].

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Hemodynamics↗