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Biomedical subjects

I Asher

Publications and source records attributed to I Asher.

6 recordsLinked to original sources

Prevalence and natural history of otitis media with perforation in Maori school children.

New Zealand Maoris are one of five ethnic groups in developed countries known to have a high rate of ear disease, including perforation of the eardrum (CSOM). It is a strongly held belief by otolaryngologists whose practice dates back to the 1960's that the prevalence of CSOM in Maori children is gradually falling. Despite the obvious practical implications this change has not yet been documented. The aim of the study was to compare the prevalence of CSOM in two surveys conducted in 1978 and 1987 of children living in a North Island Maori community. A second aim was to examine the natural history of CSOM in these children. The raw data from the 1978 study were reviewed. Of 134 children aged 4-13, 12 had CSOM. In 1987 the same age group yielded 12 children out of 250 with CSOM. The prevalence of CSOM fell from 9 per cent to 4 per cent. The incidence of new perforations in 1987 was 1.3 per cent per child per year. It is concluded there has been a fall in the rate of CSOM, although otitis media remains a significant problem for these children. The probability of a perforation healing was influenced by whether or not the perforation had been observed before: at least 35 per cent of perforations seen for the first time healed, but none of the perforations seen on two occasions healed spontaneously. It was concluded that perforation of the eardrum can be managed conservatively at first.

Adolescent

Sulpiride-induced hyperprolactinemia and impotence in male psychiatric outpatients.

The relationship between erectile dysfunction and sulpiride stimulatory effect on prolactin secretion was studied in 13 married male psychiatric outpatients. The patients population was comprised of 2 groups: patients with anxiety disorders resistant to minor tranquilizers who were treated with sulpiride up to 200 mg/day, and schizophrenic patients treated with sulpiride 600 mg/day. All the patients were maintained on maximal dose for a period of 3 weeks. Sexual function and blood prolactin levels were monitored once weekly. The patients who developed impotence were maintained on higher doses of sulpiride and exhibited higher prolactin levels in comparison to the potent patients. Restoration of potency was observed after reduction or discontinuation of sulpiride treatment. It is concluded that sulpiride induced impotence is associated with hyperprolactinemia.

Adult

Fluorimetric study of the binding of protoporphyrin to haemopexin and albumin.

Fluorescence spectra of protoporphyrin bound to its most affinitive site on human serum albumin, bound to human haemopexin and dissolved in human plasma reveal that, when present in plasma, at least 90% of this porphyrin is bound to albumin. Human serum albumin binds protoporphyrin with an affinity KA = 3 X 10(9)M-1 in phosphate-buffered saline. The affinity of haemopexin for protoporphyrin is 4 times smaller. From these data it is concluded that less than 1% of plasma protoporphyrin is bound to haemopexin. Implications of the data for protoporphyrin transport and clearance are discussed.

Animals

Ethanol and sulfamethoxazole for functional evaluation of male accessory glands.

The secretory function of male accessory glands was tested with two chemical markers, ethanol and sulfamethoxazole (SMZ). Fifty-eight men ingested 70 ml of 40% ethanol; ethanol reached a peak in the blood and prostatic fluid within 0.5 hr, which was sustained for 2 hr. Twenty-one men ingested 1.6 g of SMZ; SMZ reached a peak in serum and semen 4 hr after ingestion and was sustained in semen for 24 hr. Ethanol and SMZ were excreted equally by the prostate and seminal vesicle. Pathologies of the prostate were not correlated with either ethanol or SMZ secretion.

Adult

Ambiguities in IR and X-ray characterization of amphotericin B.

Two distinct IR spectra of amphotericin B have been reported. These differences can be obtained from the same sample by surprisingly small changes in the method of sample preparation. Type I spectra (hand-ground samples) are characterized by a sharp C = O stretching band at 1692 cm-1, and Type II spectra (vibrator-ground samples) are characterized by a broad C = O stretching band near 1710 cm-1. X-ray powder diffraction demonstrates that vibrator grinding promotes a transition from a crystalline to an amorphous phase. The two phases are not bioequivalent. Differential thermal analysis reveals a transition near 157 degrees and samples heated to 158 degrees give only Type II IR spectra. However, a marked color change accompanies such heating (i.e., structural changes affecting the chromophore have been thermally induced), while X-ray spectra show an increase of only about 30% in amorphous content. Furthermore, hand-ground samples heated to 120 degrees still display only Type I IR spectra. Thus, the vibrator-induced transition is not solely a static thermal effect. Many observed spectral lines can be assigned to specific functional groups.

Amphotericin B