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Biomedical subjects

I Andersson

Publications and source records attributed to I Andersson.

At least 181 records · Page 10Linked to original sources

Number of projections in mammography: influence on detection of breast disease.

A total of 491 cases of breast cancer were reviewed to evaluate the diagnostic importance of the three standard projections; craniocaudal, mediolateral, and oblique. With only one projection, 90% of the malignancies would have been detected; with two and three projections the percentages rose to 94% and 95%, respectively. Nonvisualization was due to either juxtathoracic position of the tumor or superimposition of dense tissues. A relation was found between the position of a juxtathoracic tumor and the projection in which it was visualized. The mean diameter of tumors not visible due to superimposition of dense tissues was smaller than that of the whole material. In breast screening programs, use of two projections, the oblique and craniocaudal, is recommended.

Breast Neoplasms↗

Reduction of absorbed dose in radiography of the breast. Experience with a new screen-film combination.

The mean absorbed dose in radiography of the breast with industrial film (Mamoray T3, Agfa-Gevaert), the Lo-dose system (Du Pont) and a new screen-film combination (MR 50-Mamoray RP 3, Agfa-Gevaert) was determined. The mean values were 17,2 and 1 mGy, respectively. Thus, the absorbed dose was considerably reduced by using the screen-film combination. This is of utmost importance as the potential risk of inducing malignancy is remarkably reduced, probably negligible.

Female↗

Intestinal decarboxylation of orally administered L-dopa. Influence of pharmacological preparations, dose magnitude, dose sequence and food intake.

The intestinal decarboxylation and the absorption of orally administered L-dopa have been studied in 20 parkinsonian patients in different conditions. The decarboxylation generally amounted to 50-70% of the dose given, i.e. only 30-50% of orally administered L-dopa reached the general circulation. The shape of the plasma concentration curve varied individually and with the resolvation time of the type of pharmacological preparation given. No obvious difference in the degree of intestinal decarboxylation was observed when tablets with different resolvation times were given but the net absorption of L-dopa was somewhat greater when it was given as a solution. The decarboxylation in the intestinal organs was found to be rather constant at different times of the day. Isocaloric meals, whether rich in protein or carbohydrate, caused a delay in absorption of L-dopa, but did not change the degree of decarboxylation. Diurnal variations in the clinical response to L-dopa, could, thus, not be related to diurnal variations in the decarboxylation in the intestinal organs. The delay in L-dopa absorption after meals may be misinterpreted as lack of response. At dosage with short intervals, the delay may cause an additive effect of two doses.

Administration, Oral↗