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Biomedical subjects

I Amende

Publications and source records attributed to I Amende.

51 records · Page 3Linked to original sources
PubMed1976

[Cineradiographical studies of local ventricular motility before and after aorto-coronary bypass (author's transl)].

The purpose of this study was to observe the effect of surgical revascularization on the motility of the left ventricular segment distal to a high grade coronary stenosis. In 17 patients with LAD bypass local relative segment shortening lambda (lambda = diastolic length - systolic length/diastolic length X 100) was determined measuring the distances of coronary bifurcations and surgically implanted myocardial metal markers frame by frame in high speed cineradiography. A group of 14 patients whose angina pectoris was abolished after operation and where bypass proved to be patent showed significant increase of lambda within the first postoperative days (lambda preop. = 3,4 +/- 18,3 SD, lambda postop. = 18,9 +/- 8,0 SD, p less than 0.05). Paradoxical movement had disappeared in 4 cases. In the following two-monthly controls up to one year no significant further alterations of local motility were seen. Three patients with persisting angina did not show any increase of segment shortening. It is concluded that aorto-coronary bypass surgery can restore impaired local motility in the majority of patients. The method described is useful for repeated non-invasive controls of the success of operation.

Angina Pectoris↗
PubMed1976

[X-ray cinematographic studies of local ventricular dynamics after aortocoronary bypass].

In 12 patients with high-grade coronary stenosis local motility before and after aortocoronary vein bypass was estimated by cineradiography of coronary bifurcations and surgically implanted myocardial metal markers. A group of patients with relief of angina showed significant increase of local segment shortening within the first postoperative days. During the following months no further alteration occurred. In three patients with persisting angina no improvement of local motility could be found.

Cineradiography↗
PubMed1975

Left ventricular contraction and relaxation in patients with coronary heart disease.

The relationship of left ventricular relaxation and compliance to the mechanism of elevation of left ventricular enddiastolic pressure during ischemia was investigated. Isovolumic left ventricular contraction, relaxation, and diastolic pressure-volume relationship were studied in controls and in coronary heart disease patients. Patients were studied at similar heart rates during ergometric exercise and pacing. Diastolic aortic, left ventricular systolic, and incisural pressure were not significantly different in both groups at rest, pacing, and exercise. Left ventricular dP/dtmax increased during pacing and exercise in controls (P smaller than 0.05; P smaller than 0.01) and in coronary heart disease patients (P smaller than 0.01 for both); whereas left ventricular dP/dtmin increased only in controls during exercise (P smaller than 0.01). Peak measured velocity of shortening (Vpm) and of lengthening (Vpmr) of the contractile elements was calculated as (dP/dt)/p. Vpm and Vpmr increased in controls during both pacing (P smaller than 0.05; P smaller than 0.02) and exercise (P smaller than 0.01 for both). In coronary heart disease patients Vpm increased during pacing (P smaller than 0.01) while Vpmr did not differ significantly. During exercise both Vpm and Vpmr were unchanged. In patients with coronary heart disease paced to angina, diastolic logarithmic pressure-volume relationship showed change in slope (P smaller than 0.05) of the regression line and upward shift in intercept b (+0.25; P smaller than 0.001). Ischemia produced an impaired contractile state, delayed relaxation and generation of active diastolic tone in the intact ventricle.

Adult↗
PubMedDate not supplied

Nisoldipine versus isosorbide dinitrate in coronary heart disease: results of a double-masked study.

The efficacy and tolerability of a twice-daily dose of 5 mg of nisoldipine versus 40 mg of sustained-release isosorbide dinitrate (ISDN) were compared in a randomized, double-masked study in 91 patients. During the 21-day treatment period, the mean time taken during bicycle ergometry to the appearance of an ST segment depression of at least 0.1 mV compared with the resting value increased from 287 +/- 129 seconds to 391 +/- 150 seconds in the nisoldipine group and from 254 +/- 140 seconds to 350 +/- 191 seconds in the ISDN group. The mean value at the end of treatment calculated by using analysis of covariance was 383 seconds in both groups. The difference between the two treatment groups was not statistically significant. The mean ST segment depression at individually maximal workload decreased from 0.19 +/- 0.07 mV to 0.12 +/- 0.08 mV in the nisoldipine group and from 0.18 +/- 0.07 mV to 0.14 +/- 0.08 mV in the ISDN group. The mean total duration of exercise increased from 420 +/- 161 seconds to 497 +/- 140 seconds in the nisoldipine group and from 425 +/- 167 seconds to 456 +/- 168 seconds in the ISDN group. In the nisoldipine group, 9 patients reported 12 adverse events that were considered to be possibly or probably related to the test medication; in the ISDN group, 13 patients reported 26 adverse events. Although the anti-ischemic effect of the two treatments was comparable, nisoldipine was descriptively superior to ISDN in terms of tolerability.

Aged↗
PubMedDate not supplied

Posttraumatic myocardial infarction with severe coronary intimal dissection documented by intravascular ultrasound.

We present a case of posttraumatic myocardial infarction after blunt chest trauma in a previously healthy man. Coronary angiography showed an eccentric occlusion in the midportion of the left anterior descending artery. Subsequent intracoronary ultrasound imaging revealed a severe intimal dissection. The outcome after intracoronary stent placement was excellent. This rare but potentially harmful complication of blunt chest trauma should be kept in mind and coronary angiography performed immediately when coronary occlusion is suspected. Intravascular ultrasound imaging is a helpful tool in the assessment of coronary artery occlusion caused by intimal dissection.

Adult↗
PubMedDate not supplied

Dislodgement of a Wiktor stent during intracoronary ultrasound examination.

We report a case of stent dislodgement complicating adjuvant intracoronary ultrasound (ICUS) imaging that required emergency coronary bypass grafting. This probably very rare complication gains importance since ICUS is increasingly used to confirm adequate stent expansion and full coverage of the lesion.

Acute Disease↗