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Biomedical subjects

I A Shah

Publications and source records attributed to I A Shah.

At least 37 records · Page 2Linked to original sources
PubMed1991

Hodgkin's disease associated with systemic lupus erythematosus.

We report on the rare association of Hodgkin's disease with systemic lupus erythematosus. Two years after the diagnosis of systemic lupus erythematosus, the patient developed upper abdominal pain, jaundice, splenomegaly, and fever of unknown origin. He had a rapidly fatal clinical course, despite being treated for systemic lupus erythematosus, cholecystitis, and possible sepsis. Autopsy revealed Hodgkin's disease, lymphocyte-depletion type, involving lymph nodes, liver, spleen, and bone marrow. The awareness of the association of Hodgkin's disease with systemic lupus erythematosus and its modes of presentation will help in the early diagnosis and management of such patients.

Hodgkin Disease↗
PubMed1991

Immunoreactivity of neurofilament proteins in neuroendocrine neoplasms.

We immunostained histologic sections of formalin-paraffin-processed specimens from 112 neuroendocrine tumors to evaluate the expression of intermediate filaments, especially neurofilament (NF) protein. The commercially available anti-human NF protein monoclonal antibody was raised against the Mr 200,000 and 70,000 components of neurofilaments. None of our tumors exhibited unequivocal immunoreactivity for Mr 200,000 or 70,000 neurofilament proteins. The failure of a tumor to express the Mr 200,000 or 70,000 component of NF protein does not question its neuroendocrine nature. However, the unequivocal positivity for Mr 200,000 or 70,000 components of NF in an undifferentiated tumor with a differential diagnosis between neuroendocrine small-cell carcinoma and a neurogenic tumor should support the latter consideration.

Adenocarcinoma↗
PubMed1991

Radiation-induced malignant fibrous histiocytoma of the pulmonary artery.

We describe a malignant fibrous histiocytoma (MFH) of the pulmonary artery. The patient received, 25 years ago, at the age of 43 years, radiation therapy to the chest for squamous-cell carcinoma of the lung. We believe the patient's second tumor was induced by radiation and, to our knowledge, this case represents the first report of radiation-induced MFH of the pulmonary artery. The diagnosis was confirmed by findings from electron microscopy and extensive studies with immunohistochemical stains. We discuss the value of studies with immunohistochemical stains in the diagnosis and differential diagnosis of MFH. The presentation of this case underlines that MFH can occur in the pulmonary artery and may be--as is the MFH in other locations--induced by radiation.

Aged↗
PubMed1991

Cytokeratin immunohistochemistry as a diagnostic tool for distinguishing malignant from benign epithelial lesions of the prostate.

The basal cell layer (BCL) is believed to be absent in malignant but present in nonmalignant epithelial lesions of the prostate. Using the avidin-biotin-peroxidase complex (ABC) immunoperoxidase method, we examined the value of the monoclonal antibody cocktail MA-903, which stains selectively the prostatic BCL layer, in the distinction between benign and malignant epithelial lesions of the prostate. We immunostained histologic sections of 63 prostates, containing 235 morphologic appearances: normal prostate glands, 43; benign prostate hyperplasia (BPH), 59; basal cell hyperplasia (BCH), 24; adenosis, seven; prostatic intraductal neoplasia (PIN 1), 21; PIN 2, 25; PIN 3, 16; and cancer, 40. Some degree (continuous, continuous with focal disruption, and disrupted patterns) of basal cell staining was demonstrable in all normal and BPH, BCH, and PIN 1 lesions, but was absent in 39 of 40 cancers. However, not every gland in benign lesions stained positively. Further, two of 25 PIN 2 and six of 16 PIN 3 lesions failed to reveal BCL. Our results suggest that the presence or absence of BCL, predicated on cytokeratin MA-903 immunoreactivity, may be a useful indicator in the distinction between benign and malignant epithelial lesions of the prostate.

Antibodies, Monoclonal↗
PubMed1990

Effect of truncal vagotomy on parietal cell mass and antral gastrin cell mass in dogs.

Vagotomy is known to reduce acid secretion and to increase serum gastrin concentrations. However, there is minimal information on the effect of vagotomy on parietal cell mass or gastrin cell mass. Basal and maximal acid secretions and fasting serum gastrin concentrations were measured in 22 gastric fistula dogs with pyloromyotomy before and up to 56 days following complete bilateral truncal vagotomy (n = 11) or sham vagotomy (n = 11). Dogs underwent total gastrectomy on postoperative days 9 (n = 5 per group) or day 56 (n = 6 per group). Parietal cells were stained with Luxol fast blue and parietal cell mass determined with computer-assisted histomorphometry. Parietal cell mass averaged 10.68 +/- 0.90 billion in control dogs and correlated significantly with maximal acid output (r = 0.76; P less than 0.01). Vagotomy reduced maximal acid output by 40%-50% (P less than 0.001) but had no significant effect on parietal cell mass (8.99 +/- 1.00 billion). Vagotomy increased serum gastrin concentrations significantly, but antral gastrin cell mass in vagotomized dogs (5.66 +/- 1.00 million) was not significantly different than that in control dogs (4.74 +/- 0.50 million). Thus, vagotomy did not lead to parietal cell hypoplasia or gastrin cell hyperplasia despite profound alterations in parietal cell and gastrin cell function.

Animals↗
PubMed1989

Leiomyoblastoma stomach.

Three patients with epithelioid leiomyomatous tumors (leiomyoblastomas) of the stomach are presented.

Adult↗
PubMed1987

[Percutaneous transhepatic cholangioscopy. A new method for the diagnosis of bile duct malignancies].

Percutaneous transhepatic cholangioscopy combines the advantages of endoscopic and radiological examinations. It makes it possible to assess the intraluminal spread of bile duct disease as well as histological and cytological examination of biopsies obtained under vision. Eight PTCs were performed without complication in seven patients with cancer of the bile duct. In four, the histology and extent of the tumour was defined endoscopically before any surgical intervention. In three others the results of treatment were objectified. A flexible choledochoscope, as used intraoperatively, was employed (CHF-P10). A stepwise dilatation of the percutaneous access-route was undertaken in several sessions in order to avoid bleeding complications. The procedure is done without general anaesthesia.

Adenocarcinoma↗
PubMed1984

Multiple primary malignant tumors involving the large bowel.

We reviewed 5680 autopsy protocols in order to determine the frequency of Multiple Primary Malignant Tumors (MPMT) in different organs. The large bowel was the organ most frequently involved, making up to 32 per cent of all MPMT cases. Of 26 patients with colorectal MPMT, six were multicentric in the large bowel, and 20 were associated with extracolonic malignancies. The tissues harboring primary malignancies were, in order of decreasing frequency, liver, lung, and female and male reproductive organs. We compared the exact location of large bowel cancers in patients with and without a prior cholecystectomy; there was no statistically significant difference between the two groups, especially for right-sided colonic carcinoma in women.

Aged↗
PubMed1984

Bioptic diagnosis of Wegener's granulomatosis in the absence of vasculitis and granulomas.

We report a case of Wegener's granulomatosis (WG) which differed significantly from the WHO-definition. The patient presented himself with fever and skin lesions which exacerbated after penicillin therapy. The nasal biopsy did not reveal the expected classical vasculitis and granulomas, which were present at autopsy only in the liver and spleen. We emphasize that vasculitis and granulomas may be absent in the biopsy specimen. We stress the institution of chemotherapy with cyclophosphamide, once the clinicopathological impression of WG is probable.

Aged↗
PubMed1984

Multiple primary malignant tumors involving the liver.

We reviewed 5,680 autopsy protocols from the Black Forest area of West Germany and found 2,005 (35.3%) malignant neoplasms; among them there were 93 cases (4.9%) with 186 (9.3%) multiple primary malignant tumors (MPMTs) arising in two different organs or organ systems. Whereas single primary malignant neoplasms of the liver constituted only 3.4% of the total malignant neoplasms, the liver was involved in 11% cases of MPMTs. We also compiled data on the involvement of other organs with MPMTs.

Aged↗
PubMed1983

Halothane-associated granulomatous hepatitis.

We present a case of halothane-associated-hepatitis in a 34-year-old woman. She received halothane anesthesia twice within a 6-day interval, 2 weeks prior to the onset of symptoms. Liver histology was nonspecific, and unusual in showing not only lobular hepatitis but also granulomatous changes. Since the clinical picture and the laboratory values were more and the liver histology less in keeping with the diagnosis, we emphasize that the former two parameters should play a vital role in establishing or discarding the diagnosis of halothane-induced hepatitis.

Adult↗