Biomedical subjects
Publications and source records attributed to I A Magnus.
The efficacy of oral beta-carotene for the prevention of photosensitivity symptoms in erythropoietic protoporphyria was studied in a controlled cross-over trial in which it was compared with a placebo. No significant difference was found between the 2 preparations. Patients' symptoms showed statistically significant association with sunlight hour records.
A study of the long term effects of radiation on the visual appearance and mechanical properties of mouse skin is presented. The effects associated with the hair follicle (greying and alopecia) increase monotonically with exposure. Other effects (load, extension and stress at rupture and scarring of the skin) all show a reversal at the highest exposures. The skin thickness changes little with exposure, while the skin stiffness exhibits a shoulder on the response curve. Possible mechanisms underlying these effects are discussed.
Quantitative studies on sunburn cell (SBC) production in mouse epidermis are reported. Ultraviolet radiation (UVR), 260-300 nm, produced a dose related effect with respect to SBC formation. Maximal spectral reactivity was at wavelengths shorter than 300 nm. In 8-methoxypsoralen (8-MOP) photosensitization, SBCs were also produced and this response is dose related with respect to long wave UVR dose. In fluorescein photosensitization, provoked by 487 nm light, SBCs were not produced. The response in 8-MOP photosensitization and 254 nm UVR (given alone) differed in respect of time course, but it is considered that both may perhaps to initiated by a DNA lesion.
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Skin porphyrin assays and photobiological studies in normal and porphyric rats suggest that in the latter, skin photosensitivity to 400 nm radiation is associated with raised uroporphyrin and 7-carboxylic porphyrin in the skin.
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