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Biomedical subjects

I A Jaffe

Publications and source records attributed to I A Jaffe.

At least 55 records · Page 3Linked to original sources
PubMed1974

Effect of D-penicillamine on poliovirus replication in HeLa cells.

A series of mercaptan compounds were studied with respect to their ability to inhibit the growth of poliovirus in cultured cells. Of the compounds tested only d-penicillamine possessed antiviral activity. There was no direct effect on the virus itself, nor were the processes of adsorption, penetration and uncoating, or virus-induced "shut-off" of host cell protein synthesis inhibited. At concentrations where there was no effect on host cell RNA or protein synthesis, d-penicillamine caused a marked inhibition of virus-specific RNA and protein synthesis. Although much reduced, the relative concentrations of single-stranded and double-stranded viral RNA synthesized in the presence of d-penicillamine was unchanged. Similarly, all apparent precursor and cleavage product proteins could be synthesized in the presence of the drug. The inhibitory effect was reversible, after a lag of 1.5 to 2 h after removal of the drug, and normal yields of virus could be obtained. The structural and functional properties of d-penicillamine are discussed in relation to requirements for anti-polioviral activity.

Antiviral Agents↗
PubMed1968

Copper: relation to penicillamine-induced defect in collagen.

When rats were depleted of copper by administration of a copperdeficient diet, no abnormalities developed in dermal collagen. In contrast, marked changes were produced by penicillamine although the degree of copperdeficiency induced by the drug was less. Large additions of copper to the diet failed to prevent the penicillamine-induced collagen defect when the drug was given parenterally. The effect of penicillamine on soft-tissue collagen appears to be unrelated to its copper-chelating properties.

Animals↗