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Biomedical subjects

I A Born

Publications and source records attributed to I A Born.

47 records · Page 3Linked to original sources
PubMed1986

[Immunohistologic analysis of chronic obstructive sialadenitis. I. Changes in the expression of antigens of the major histocompatibility complex].

In the course of electrolyte sialadenitis progressing towards obstructive sialadenitis, changes in the epithelial expression of antigens of the major histocompatibility complex (MHC) occur even before morphological alterations and inflammatory cells can be detected. Class I antigens are enhanced and induced, and Class II antigens are induced. These changes begin focally. Only the expression of HLA-A,B,C and -DR in acinar epithelium is linked to the close vicinity of lymphohistiocytic infiltrates. In later stages of the disease the foci tend to fuse and antigenic changes are pronounced in areas of fibrosclerosis and parenchymal atrophy. The altered MHC antigen expression induced by chronical saliva congestion probably represents an important part of the postulated "immunoreaction in the duct epithelium" supposedly giving rise to this type of immunosialadenitis.

Adult↗
PubMed1986

[Limited function of the large salivary glands of the head. A new aspect for the etiopathogenesis of cancers of the oral cavity, oropharynx and hypopharynx].

Function and morphology of the major salivary glands were investigated in patients suffering from carcinomas of the oral cavity, the oropharynx and the hypopharynx. In comparison to the results obtained from healthy control subjects, the tumour patients showed significantly decreased flow-rates of parotid and submandibular saliva. Furthermore the excretion of IgA, lysozyme and total protein and the pH-value in both, the parotid and the submandibular saliva of the patients was significantly lowered. The histological feature of the salivary glands of the patients was characterized by interstitial deposition of fat. In several cases a swelling and a degranulation of the acinar cells was observed additionally. Other patients showed an atrophy of the acinar cells. Sometimes an inflammatory reaction could also be noted in the submandibular and/or the parotid glands of patients suffering from head and neck cancer. The decreased salivary gland function reflects a reduction of the protective mechanisms of the oral cavity and the pharynx. Additionally it enables an increased penetration of environmental carcinogens through the mucous surface, and therefore has to be discussed as a factor for the etiology of carcinomas of the upper aerodigestive tract.

Humans↗
PubMed1986

[Well-differentiated liposarcoma of the submandibular region. Case report and literature review].

Liposarcoma of the head and neck are seen only occasionally. In particular manifestations of this tumour in the submandibular region or the floor of the mouth are very rare. The pathohistological features and the clinical picture of these tumours are described by means of a case report and a review of the literature. The close correlation between histological differentiation and prognosis of liposarcoma is underlined. The recommended possibilities of treating these rare soft tissue tumours are discussed.

Adipose Tissue↗
PubMed1985

[Sarcoidosis (Boeck disease) of the parotid gland].

Involvement of the parotid gland with sarcoidosis occurs in 1-6% of the patients. In rare cases parotitis represents the initial clinical manifestation of sarcoidosis. In that case, the otorhinolaryngologist is usually the first to be confronted with this disease and may enable an early diagnosis and therapy. In the present paper a rare case of isolated sarcoidosis of the parotid gland is reported. The results obtained by different examination techniques are demonstrated and their relevance for the diagnosis of sarcoidosis is discussed.

Adult↗
PubMedDate not supplied

S-phase fractions and DNA-ploidy of oropharyngeal squamous epithelium carcinomas compared with histologic grade, stage, response to chemotherapy and survival.

DNA-ploidy and the percentage of S-phase fractions in 55 primary oropharyngeal squamous epithelium carcinomas were measured by DNA-Flow Cytometry (FCM). The data were compared with the histologic grade, the stage and the response of the tumours to cytostatic chemotherapy. A significant correlation was found between the histologic grade and the mean percentage of S-phase fractions (p less than 0.01). No correlation could be found between the FCM measurement data and the tumour stage. Carcinomas with an amount from 4.0 to 10.4% S-phase fractions responded to chemotherapy by complete remission, and those with 10.0 to 13.3% S-phase fractions by partial remission. The group of non-responders could be subdivided into two subgroups: non-responders with low amounts of S-phase fractions (1.1-3.9%), and non-responders with very high amounts of S-phase fractions (11.6-16.6%). FCM data, histologic and clinical prognostic factors were summed up to a prognostic score. The number of score points showed a significant correlation to the length of survival in months after diagnosis of the tumour (p less than 0.00001). FCM may be used as an additional diagnostic tool for a better biological characterization of the neoplastic tissue, especially as an aid for grading, prediction of the response to chemotherapy and the length of survival.

Adult↗
PubMedDate not supplied

Studies on the interaction and exchange of inhibitors and proteases on the surface of tumour cells in frozen sections.

We have used frozen sections of squamous cell carcinoma as a convenient source of a cell surface protease associated with tumour cells. This protease has been referred to as guanidinobenzoatase (GB) and is now known to be functionally identical to tissue plasminogen activator (t-PA). The use of a fluorescent competitive inhibitor of GB enabled the enzymic status of GB to be determined, i.e. was the enzyme active, latent or removed from our test system. The cell surface GB was then demonstrated to interact with extractable cytoplasmic inhibitors obtained from these sections. We then used a protected form of the GB in the absence of these internal inhibitors; such sections were used to transfer the GB to fibrin fibrils, thus exposing the presumptive receptor on the tumour cell surfaces. Texas red labelled t-PA was then shown to bind to the tumour cells in these pretreated sections from which the GB had previously been removed. We believe that the surface of tumour cells can be used to study the interaction of the naturally occurring inhibitors with GB and also that the cell surface receptors for GB can be used to study the binding of t-PA to cell surfaces.

Aminacrine↗
PubMedDate not supplied

[Use of low-molecular fluorescent dyes for localizing tumor cells].

A novel fluorescence microscopic technique, based on the application of low-molecular fluorescent dyes, was used to study the expression of the enzyme guanidinobenzoatase in malignant tumors of the head and neck area. Frozen sections have shown that moderately and highly differentiated squamous cell carcinomas express this enzyme, particularly in the area of tumor invasion. The protease is capable of breaking down fibronectin, an important component of the extracellular matrix. In less differentiated squamous cell carcinomas as well as malignant melanomas almost all tumor cells exhibited guanidinobenzoatase activity. The fluorescence microscopic technique presented here provides a fast and easy method for the localization of tumor cells. At the same time it provides a better understanding of the biological control of a tumor-associated protease, thus furnishing important new information on the invasion behavior of malignant tumors.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

[PVP granuloma--a complication in the treatment of facial neuralgia].

A 61-year-old female patient suffering from neuralgiform facial pain developed a PVP granuloma, after she had received peripheral conduction anesthesia treatment with a local anesthetic containing polyvinylpyrrolidone over many years. The clinical symptoms and treatment of this pseudotumor as well as the features distinguishing it from real tumors, particularly chordomas, are indicated.

Anesthesia, Local↗
PubMedDate not supplied

A rapid technique for the fluorescent location of pleomorphic adenoma cells in frozen sections of human salivary glands.

Both acinar cells and pleomorphic adenoma cells possess a cell surface protease, guanidinobenzoatase (GB) which can be located with a fluorescent probe for the active centre of this enzyme. We have developed a rapid, cheap, fluorescent technique for the differential location of pleomorphic adenoma cells and acinar cells in frozen sections of salivary glands. The fluorescence of other cells (which also possess GB) is selectively quenched, such that only the acinar and pleomorphic adenoma cells are visualised by fluorescent microscopy.

Adenoma, Pleomorphic↗
PubMedDate not supplied

[Collagen and fibrin as biologic binders for granular hydroxylapatite].

In an animal experiment the use of the biologic binders collagen and fibrin for the temporary stabilization of the shape of granular hydroxyl apatite grafts has been tested. A simple way of producing a hydroxyl apatite fibrin paste involves the use of a thrombin solution diluted to 1 i.u./ml. The fibrin-bound polygonal granules (Interpore 200) studied did not grow denser during the interposition of fibrous tissue, while the molded specimens of collagen-bound granules (Alveoform) underwent condensation involving a 30% decrease in intergranular distance.

Adhesives↗