Biomedical subjects

Huilin Xiong

Publications and source records attributed to Huilin Xiong.

3 recordsLinked to original sources

PubMed2006

Kernel-based distance metric learning for microarray data classification.

BACKGROUND: The most fundamental task using gene expression data in clinical oncology is to classify tissue samples according to their gene expression levels. Compared with traditional pattern classifications, gene expression-based data classification is typically characterized by high dimensionality and small sample size, which make the task quite challenging. RESULTS: In this paper, we present a modified K-nearest-neighbor (KNN) scheme, which is based on learning an adaptive distance metric in the data space, for cancer classification using microarray data. The distance metric, derived from the procedure of a data-dependent kernel optimization, can substantially increase the class separability of the data and, consequently, lead to a significant improvement in the performance of the KNN classifier. Intensive experiments show that the performance of the proposed kernel-based KNN scheme is competitive to those of some sophisticated classifiers such as support vector machines (SVMs) and the uncorrelated linear discriminant analysis (ULDA) in classifying the gene expression data. CONCLUSION: A novel distance metric is developed and incorporated into the KNN scheme for cancer classification. This metric can substantially increase the class separability of the data in the feature space and, hence, lead to a significant improvement in the performance of the KNN classifier.

Artificial Intelligence↗

PubMed2005

Optimizing the kernel in the empirical feature space.

In this paper, we present a method of kernel optimization by maximizing a measure of class separability in the empirical feature space, an Euclidean space in which the training data are embedded in such a way that the geometrical structure of the data in the feature space is preserved. Employing a data-dependent kernel, we derive an effective kernel optimization algorithm that maximizes the class separability of the data in the empirical feature space. It is shown that there exists a close relationship between the class separability measure introduced here and the alignment measure defined recently by Cristianini. Extensive simulations are carried out which show that the optimized kernel is more adaptive to the input data, and leads to a substantial, sometimes significant, improvement in the performance of various data classification algorithms.

Empirical Research↗

PubMed2004

Branching competitive learning network: a novel self-creating model.

This paper presents a new self-creating model of a neural network in which a branching mechanism is incorporated with competitive learning. Unlike other self-creating models, the proposed scheme, called branching competitive learning (BCL), adopts a special node-splitting criterion, which is based mainly on the geometrical measurements of the movement of the synaptic vectors in the weight space. Compared with other self-creating and nonself-creating competitive learning models, the BCL network is more efficient to capture the spatial distribution of the input data and, therefore, tends to give better clustering or quantization results. We demonstrate the ability of the BCL model to appropriately estimate the cluster number in a data distribution, show its adaptability to nonstationary data inputs and, moreover, present a scheme leading to a multiresolution data clustering. Extensive experiments on vector quantization of image compression are given to illustrate the effectiveness of the BCL algorithm.

Artificial Intelligence↗