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Biomedical subjects

Hugh Taylor

Publications and source records attributed to Hugh Taylor.

5 recordsLinked to original sources
PubMed2006

HOXA10 expression in ectopic endometrial tissue.

OBJECTIVE: To evaluate HOXA10 expression in endometriosis. DESIGN: Laboratory study using human tissue. SETTING: Academic research center. PATIENT(S): Eutopic endometrial tissue was collected from 20 fertile women without endometriosis. Ectopic endometrial tissues from pelvic peritoneum, ovary, and lung parenchyma were collected from 20 women undergoing surgery for endometriosis. INTERVENTION(S): HOXA10 protein expression and localization with immunohistochemistry. MAIN OUTCOME MEASURE(S): Quantitative analysis of HOXA10 expression, according to H score. RESULT(S): Both eutopic and ectopic endometrial tissue expressed HOXA10. Ectopic endometrial tissue had lower stromal HOXA10 expression compared with eutopic endometrium. The mean H score for stromal expression of HOXA10 was 7.6 in eutopic endometrium and 1.3 in ectopic endometrial tissue. Glandular epithelium from both eutopic and ectopic endometrium had similarly low HOXA10 expression. HOXA10 was also expressed at low levels in lung parenchyma containing endometriosis and in ovarian endometriomas. CONCLUSION(S): HOXA10 is expressed in endometriosis at locations outside of the normal HOXA10 expression domain, where it is likely necessary to impart endometrial developmental identity on endometriosis. HOXA10 might be necessary for "de novo" endometrial development. However, the diminished expression of HOXA10 in ectopic endometrium might not allow for normal endometrial development and might contribute to the pathogenesis of endometriosis by creating P resistance.

Adult↗
PubMed2006

A cohort study of incident myopia in Singaporean children.

PURPOSE: To determine the risk factors of incident myopia in a school-based cohort study in Singaporean children. METHODS: A 3-year prospective cohort study was conducted in Singaporean school children aged 7 to 9 years in three schools at entry. Chinese children without myopia at baseline (n = 994) were included in the analysis. The main outcome was incident myopia, defined as spherical equivalent (SE) at least -0.75 D based on cycloplegic autorefraction. Other definitions of incident myopia, at least -0.5 D and at least -1.0 D, were also assessed. RESULTS: After controlling for school, age, gender, income, reading in books per week and intelligence quotient (IQ) test scores, we found the relative risk (RR) of incident myopia defined as -0.75 D to be 1.55 (95% confidence interval [CI] 1.18-2.04) for two versus no myopic parents. The multivariate RR of myopia for IQ in the third versus first tertile was 1.50 (95% CI, 1.19-1.89). However, the RR of incident myopia was 1.01 (95% CI, 0.97-1.05) for every unit increase in books read per week. Similar results were obtained with definitions of -0.5 and -1.0 D for incident myopia. CONCLUSIONS: These data provide new prospective evidence of essential links between parental myopia, IQ scores and subsequent myopia development. However, reading in books per week was not associated with incident myopia.

Child↗
PubMed2005

Exposure to Chlamydia pneumoniae infection and progression of age-related macular degeneration.

Recent studies have found an association between exposure to Chlamydia pneumoniae infection and risk of age-related macular degeneration (AMD). To assess a potential risk of AMD progression posed by exposure to C. pneumoniae, the authors reexamined Australian residents in 2001-2002 who were aged 51-89 years with early AMD at baseline (1992-1995). Examination included macular photography and an enzyme-linked immunosorbent assay to determine antibody titers to the elementary bodies from C. pneumoniae AR39. AMD progression was assessed quantitatively, using both coarse and fine progression steps following an international classification for AMD grading, and also qualitatively, by side-by-side comparison of baseline and follow-up macular photographs. Serologic data were available for 246 of 254 (97%) subjects. AMD progression was associated with a higher antibody titer. After adjustment for age, smoking, family history of AMD, history of cardiovascular diseases, and source study, the subjects in the upper tertiles of antibody titers were 2.1 (95% confidence interval: 0.92, 4.69), 2.6 (95% confidence interval: 1.24, 5.41), and 3.0 (95% confidence interval: 1.46, 6.37) times more at risk of progression than those in the lowest tertile, using three definitions of progression, respectively. The fact that seroreactivity to C. pneumoniae was independently associated with the risk of AMD progression suggests that C. pneumoniae infection may be an additional risk factor for AMD progression.

Aged↗