Biomedical subjects

Huabei Jiang

Publications and source records attributed to Huabei Jiang.

21 records · Page 2Linked to original sources

PubMed2002

Measurement of particle size distribution in multilayered skin phantoms using polarized light spectroscopy.

We report on the ability to use polarized light to measure the particle size distribution of thin layers of polystyrene microspheres on top of a solid Intralipid phantom. The optical properties of each layer were adjusted to match the absorption and scattering properties of the epidermis (polystyrene layer) and dermis (Intralipid layer). Polarized light was used to discriminate between light scattered from the top layer of polystyrene and the lower layer of Intralipid. In this paper we also study the effect of the thickness of the top layer on the ability to reconstruct the polystyrene size distribution.

Biophysical Phenomena↗

PubMed2002

Near-infrared optical imaging of the breast with model-based reconstruction.

RATIONALE AND OBJECTIVES: Near-infrared diffuse optical imaging may offer enhanced contrast resolution over that of the existing technologies for detection and diagnosis of breast cancer. The authors report quantitative absorption and scattering images of the human breast with model-based reconstruction methods using near-infrared continuous-wave tomographic data. MATERIALS AND METHODS: An automatic, multichannel optical imaging system was used to image the breasts of nine women: four with infiltrating ductal carcinomas, one with infiltrating lobular carcinoma, one with fibroadenoma, and three control subjects with no breast lesion. The image reconstruction methods are centered on the finite element solution of photon diffusion in breast tissue. RESULTS: Substantial contrast between tumor and adjacent parenchyma was observed. Images of the control subjects showed homogeneous optical features. In the six women with breast lesions, the locations and sizes of tumors imaged optically were accurate and consistent with the mammographic findings. CONCLUSION: The results of this pilot study show that cancers as small as 5 mm can be quantitatively imaged. In addition, preliminary data from the scattering images suggest that benign and malignant tumors can be noninvasively differentiated with optical imaging.

Adenocarcinoma↗

PubMed2002

Three-dimensional diffuse optical tomography of bones and joints.

We present for the first time full three-dimensional (3D) volumetric reconstruction of absorption images of in vitro and in vivo bones and joints from near-infrared tomographic measurements. Imaging experiments were conducted on human finger and chicken bones embedded in cylindrical scattering media using a Clemson multichannel diffuse optical imager. The volumetric optical images were recovered with our 3D finite element based reconstruction algorithm. Our results show that 3D imaging methods can provide details of the joint structure/composition that would be impossible from two-dimensional imaging methods.

Absorption↗