Biomedical subjects

Hideo Hamada

Publications and source records attributed to Hideo Hamada.

22 records · Page 2Linked to original sources

PubMed2002

Contribution of basic residues of the A helix of heparin cofactor II to heparin- or dermatan sulfate-mediated thrombin inhibition.

Inhibition of thrombin by heparin cofactor II (HCII) is accelerated 1000-fold by heparin or dermatan sulfate. To investigate the contribution of basic residues of the A helix of HCII to this activation, we constructed amino acid substitutions (K101Q, R103L, and R106L) by site-directed mutagenesis. K101Q greatly reduced heparin cofactor activity and required a more than 10-fold higher concentration of dermatan sulfate to accelerate thrombin inhibition compared with wild-type recombinant HCII. Thrombin inhibition by R106L was not significantly stimulated by dermatan sulfate. These results provide evidence that basic residues of the A helix of HCII (Lys(101) and Arg(106)) are necessary for heparin- or dermatan sulfate-accelerated thrombin inhibition.

Amino Acid Sequence↗

PubMed2002

A rare case of shunt malfunction attributable to blockage of a Codman-Hakim programmable shunt valve.

BACKGROUND: We report a rare case of shunt malfunction resulting from blockage of a Codman-Hakim programmable shunt valve by fibrinoid-like tissues. HISTORY: The patient had undergone shunt system placement for hydrocephalus after hemorrhagic infarction at the age of 8 months; a Codman-Hakim programmable shunt valve was used at that time. LATER COURSE: Two years after shunt placement, the boy suffered from irritability and poor activity when the aforementioned shunt malfunction arose following valve blockage by fibrinoid-like tissues. He underwent shunt revision and was subsequently free of symptoms.

Cerebral Hemorrhage↗

PubMed2002

Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography.

Etizolam, an anti-anxiety agent which is an antagonist of platelet-activating factor receptors, was administered to patients with chronic subdural hematoma (CSH) after hematoma removal to assess the effectiveness for preventing recurrence compared with control patients not given the drug after surgery. The remaining volumes of subdural hematomas on brain computed tomography were measured approximately 1 month after removal. Volume in the etizolam group (15 patients) was significantly smaller than in the control group (24 patients). Hematoma recurrence was not detected in the etizolam group 3 months after surgery, but occurred in the control group. The difference was significant. Etizolam administration may be useful for the prevention of recurrence of CSH.

Aged↗

PubMed2002

Endoscopic ventriculocystostomy through the septum pellucidum via the contralateral anterior horn--technical note.

Paraventricular fluid cysts have recently been treated by endoscopic fenestration performed from the cysts to the ventricular system. However, correct orientation and safe navigation of the endoscope may be difficult in patients with abnormal anatomy. Endoscopic fenestration from the ventricular system to a cyst was performed through penetration of the septum pellucidum via the anterior horn of the contralateral lateral ventricle. The advantage of this approach is correct orientation and introduction of the endoscope to the periventricular lesion because the usual landmarks can be identified in the normal contralateral lateral ventricle.

Adult↗