Biomedical subjects

Hidekatsu Takahashi

Publications and source records attributed to Hidekatsu Takahashi.

5 recordsLinked to original sources

PubMed2006

Incidence of type-2 diabetes mellitus in a large population of Japanese male white-collar workers.

Since occupation, a major socio-economic factor, may be a risk factor for type-2 diabetes mellitus (DM), we compared DM incidence among four groups of white-collar workers in a follow-up study in 13,547 Japanese men. The subjects aged 30-59 years and free from DM at baseline consisted of: (a) 3725 clerical, (b) 5575 technical/professional, (c) 3474 manager/administrative and (d) 774 sales workers. Incident DM was identified by 'fasting serum glucose >or=7.00 mmol/l' or 'under medical treatment for DM'. Hazard ratio (HR) and 95% confidence interval (CI) for incident DM were estimated using clerical workers as the reference group (HR=1.00). Baseline age, body mass index (BMI), drinking, smoking, exercise and education were computed as confounders. During mean follow-up periods of 7.4 years, 176 clerical, 264 technical/professional, 195 manager/administrative and 49 sales workers developed DM (6.0, 6.1, 8.8 and 9.4 per 1000 person-years, respectively). Sales workers aged 40-49 and 50-59 years had increased multivariate-adjusted HRs (95% CIs) of 1.55 (1.02, 2.35) and 2.01 (0.98, 4.10), respectively. Manager/administrative workers aged 50-59 years had an increased crude HR (95% CI) of 1.64 (1.02, 2.63), but the significance disappeared after BMI-adjustment (HR (95% CI: 1.46 (0.91, 2.35)). Technical/professional workers had no significant HR in any model. In conclusion, sales workers in Japan aged >or=40 years may have increased risk for DM (+55 to +100%) independent of BMI, lifestyles and education, and manager/administrative workers aged >or=50 years may have increased risk (about +65%) due to their large BMI.

Adult↗

PubMed2006

Policemen and firefighters have increased risk for type-2 diabetes mellitus probably due to their large body mass index: a follow-up study in Japanese men.

BACKGROUND: Policemen/firefighters may have increased risk for mortality from ischemic heart disease and from all causes. We compare incidence of type-2 diabetes mellitus (DM), a well-known predictor for mortality, in policemen/firefighters with that in two other worker-groups. METHODS: A follow-up study of 5,130 healthy Japanese men aged 30-49 years at baseline consisted of three worker-groups; 3,111 clerical workers, 1,122 manual/production and transport/communication workers, and 897 policemen/firefighters. Incident DM was identified by "fasting serum glucose >or=7.00 mmol/L" or/and "under medical treatment for DM." Hazard ratio (HR) and 95% confidence interval (95% CI) for incident DM was estimated by Cox's proportional hazard models using clerical workers as a reference group (HR=1.00). Baseline age, body mass index (BMI, kg/m(2)), drinking, smoking, exercise, and education were computed as confounders. RESULTS: During mean follow-up periods of 8.4 years, 155 clerical workers, 51 manual/production and transport/communication workers, and 74 policemen/firefighters had incident DM (5.9, 5.7, and 9.6 per 1,000 person-years, respectively; P=0.001 by chi(2)-test). Policemen/firefighters had significantly increased risk for incident DM against clerical workers (age-adjusted HR (95% CI): 1.65 (1.25, 2.18)), but the significance disappeared after adjustments for BMI (age- and BMI-adjusted HR (95% CI): 1.16 (0.87, 1.54)). Manual/production and transport/communication workers had no increased risk. CONCLUSIONS: Policemen/firefighters have increased risk for DM probably due to their large BMI. Body weight control may be more efficient for prevention of DM and DM-related health problems in policemen/firefighters than in other workers.

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PubMed2004

A chronological decrease in type A behavior patterns among Japanese male workers in 1995-1999.

We examined the chronological change in Type A behavior pattern (TABP) among Japanese male workers for 5 yr. A brief questionnaire to measure TABP was administered to 21,711 male workers who underwent health check-ups at least once during the period from 1995 to 1999 and were born in 1936-1965. The mean TABP scores decreased year by year linearly. Then the repeated measurement analysis of variance was performed with the data of 5,689 subjects who completed the questionnaire successively through the study period. Both year and the age effects were highly significant (p<0.001, respectively), whereas the time trends were comparable by baseline age. In conclusion, TABP among Japanese male workers decreased in all generations during the period from 1995 to 1999.

Adult↗

PubMed2002

Markers of insulin resistance in day and shift workers aged 30-59 years.

OBJECTIVES: To examine relationships between shift work and markers (metabolic abnormalities) of insulin resistance (IR). METHODS: A cross-sectional study of 2,824 day and 826 shift workers. All the subjects were male blue-collar workers aged 30-59 years. Four IR markers [(1) hypertension (systolic blood pressure >or=140 mmHg or diastolic blood pressure >or=90 mmHg or under treatment for hypertension); (2) hyperglycemia (fasting serum glucose >or=7.00 mmol/l or under treatment for diabetes); (3) hypertriglyceridemia (fasting serum triglyceride >or=1.70 mmol/l or under treatment for hyperlipidemia); (4) hypo-HDL-cholesterolemia (fasting serum HDL-cholesterol <1.04 mmol/l)] were checked. Subsequently, IR syndrome, a cluster of IR markers, was expediently diagnosed by the number (N) of IR markers found in each worker. N>or=1, N>or=2 or N>or=3 was used as a cutpoint for the diagnosis. The prevalence of each IR marker and IR syndrome was compared between the two worker groups. Age, body mass index (kg/m(2)), job, drinking, smoking, and exercise were used as confounding factors. Job, work schedule and lifestyles were based on self-administered questionnaires. RESULTS: Hypertriglyceridemia (28.7% in day workers, 31.2% in shift workers) was most prevalent (4.6%), and hyperglycemia (5.4%) was least, in the four IR markers in both worker groups. Approximately half of the subjects had at least one IR marker in both groups (N>or=1; 46.0% and 46.6%, respectively). However, a full cluster of IR markers was rare in both groups (N=4; 0.2% and 0.1%, respectively). Prevalence of IR syndrome by any cutpoints increased with age in day workers, but shift workers aged 50 years or older had lower prevalence than shift workers younger than 50 years. In subjects younger than 50 years, all IR markers (except for hypo-HDL-cholesterolemia) and IR syndrome by any cutpoints were more prevalent in shift workers than in day workers. Contrariwise, in subjects aged 50 years or older, lower prevalence of all IR markers and IR syndrome in shift workers than in day workers was found. These results were not influenced by statistical adjustments for the confounding factors by multiple logistic regression analysis. CONCLUSIONS: Shift work may be associated with IR syndrome in workers younger than 50 years. These relations may be underestimated mainly by broad definition of shift work and healthy-worker effects.

Adult↗

PubMed2002

Cross-cultural validation of the Beck Depression Inventory-II in Japan.

The Beck Depression Inventory has undergone substantial revision recently as the BDI-II to correspond to DSM-IV criteria. We developed the Japanese version of the BDI-II and examined its psychometric properties. The linguistic equivalence was verified by a back-translation method. The final translation was administered to the visitors at a public health care center, and the responses of 766 adults (age = 24-82 years, women = 40%) were analyzed. Half of the participants completed the Center for Epidemiologic Studies Depression Scale (CES-D) as well. A high level of internal consistency reliability (Cronbach's alpha = 0.87) and item homogeneity was confirmed. Exploratory factor analysis showed a two-factor structure (cognitive and somatic-affective), which was almost identical to the original model demonstrated by Beck et al. (1996, Manual for the Beck Depression Inventor Psychological Corporation, San Antonio, TX, USA). The following confirmatory factor analysis also supported the two-factor structure. Adequate correlation (r = 0.69, P < 0.001) between the total score of the BDI-II and that of the CES-D was observed. A higher score for women compared to men, without significant age differences, was consistent with the results of previous reports. We conclude that the Japanese version of the BDI-II is psychometrically robust and can be used to assess depressive symptoms in Japanese people.

Adult↗