Biomedical subjects

Henning Gibbons

Publications and source records attributed to Henning Gibbons.

9 recordsLinked to original sources

PubMed2006

Dynamics of response-conflict monitoring and individual differences in response control and behavioral control: an electrophysiological investigation using a stop-signal task.

OBJECTIVES: The aim of the present study was to investigate the functional significance of error (related) negativity Ne/ERN and individual differences in human action monitoring. A response-conflict model of Ne/ERN should be tested applying a stop-signal paradigm. After a few modifications of Ne/ERN response-conflict theory (Yeung N, Botvinick MM, Cohen JD. The neural basis of error detection: conflict monitoring and the error-related negativity. Psychological Review 2004:111(4);931-959), strength and time course of response conflict could be modeled as a function of stop-signal delay. METHOD: In Experiment 1, 35 participants performed a visual two-choice response-time task but tried to withhold the response if an auditory stop signal was presented. Probability of stopping errors was held at 50% using variable delays between visual and auditory stimuli. Experiment 2 (n=10) employed both auditory go and stop signals and confirmed that Ne/ERN effects are due to conflict induced by the auditory stop signal, and not the mere presence or absence of an additional stimulus. RESULTS: As predicted, amplitudes of both the stimulus-locked and response-locked Ne/ERN were largest for non-stopped responses, followed by successfully stopped and go responses. However, independently of response type Ne/ERN also increased with increasing stop-signal delay. Since longer delay invokes stronger response conflict, results specifically support the notion of Ne/ERN reflecting response-conflict monitoring. Furthermore, individual differences related to measures of response control and behavioral control were observed. Both low response control estimated from stop-task performance and high psychometric impulsivity were accompanied by smaller Ne/ERN amplitude on stop trials, suggesting reduced response-conflict monitoring. CONCLUSIONS: The present study supported the response-conflict view of Ne/ERN. Furthermore, the observed relationship between impulsivity and Ne/ERN amplitude suggested that individuals with low behavioral control were characterized by lower activity in anterior cingulate cortex, the neural generator of Ne/ERN, in situations of strong response conflict. SIGNIFICANCE: The present study, for the first time, employed a stop-signal paradigm to verify predictions regarding the temporal dynamics of response-conflict processing as derived from response-conflict theory of ERN.

Adult↗

PubMed2006

ERP predictors of individual performance on a prospective temporal reproduction task.

The present study aimed at investigating whether different aspects of performance on a prospective reproduction task with a standard duration of 2 s had different antecedents in the event-related potentials (ERPs) accompanying standard presentations and reproduced intervals. On each trial, first the standard duration was presented as an empty auditory interval. After a short delay, participants reproduced this interval by means of two button presses defining onset and offset of the reproduced interval. About 25 participants were divided into groups of poor and good time estimators, once based on the coefficient of variation of their reproduced durations, and once based on the absolute error score. Interestingly, for both performance measures differences between participants were accompanied by ERP differences during standard presentations rather than reproduction itself. While larger P300 amplitudes evoked by standard interval offset predicted good reproduction performance in terms of a small coefficient of variation, small absolute error scores were accompanied by larger fronto-central negative slow wave during standard presentations. The results suggest an important role of attention to both the critical events that delimit the to-be-estimated temporal intervals, and to the passing of time between these events.

Adolescent↗

PubMed2006

Response-time corrected averaging of event-related potentials.

OBJECTIVE: The present study presents a novel approach to averaging of event-related potentials (ERPs). Acknowledging latency variability of late ERP components as related to performance fluctuations across trials should improve the assessment of late portions of the ERP. METHODS: Prior to the averaging procedure stimulus-to-response epochs in the electroencephalogram (EEG) were expanded/compressed in time to match mean RT in a certain condition and participant. By means of several mathematical functions RT variability was differentially distributed over late vs. early portions of the ERP. Data from 20 participants from two conditions of an identity-based priming task were analyzed using traditional stimulus- and response-locked averaging, as well as four different RT-corrected averaging procedures. RESULTS: Area under the curve as an index of precision of LPC assessment was reliably enhanced for certain RT-corrected procedures relative to traditional ERP averaging. Moreover, a priming effect on amplitude of a distinct LPC subcomponent which could not be confirmed with traditional stimulus-locked averaging was reliably born out using a cubic RT-correction procedure. CONCLUSIONS: RT-corrected ERP averaging can outperform traditional ERP averaging in the assessment of late portions of the ERP, and experimental effects upon. SIGNIFICANCE: Cognitive ERP researchers may take advantage of the improved capability of RT-corrected averaging to establish experimental effects on amplitudes in the late ERP range.

Adult↗

PubMed2006

Multiple sources of positive- and negative-priming effects: an event-related potential study.

Event-related potential correlates of positive priming (PP) and negative priming (NP) were investigated in order to further elucidate the cognitive mechanisms involved. Thirty-six participants performed both an identity- and a location-based priming task. Repeating the target stimulus/location from the immediately preceding display produced behavioral PP. With localization, but not with identification, behavioral NP was observed when the target stimulus/location matched the preceding distractor stimulus/location. Smaller P300 amplitude accompanied identity-based PP, suggesting persisting target-specific activation. The lateralized readiness potential, an index of correct/incorrect response activation, indicated persisting central motor activation as another source of PP. Both location-based PP and NP were accompanied by reduced P1/N1 and P300 amplitudes, pointing to the involvement of inhibition of return in location-based priming. The results support the view that multiple brain processes underlie behavioral priming.

Adult↗

PubMed2005

Electrophysiological correlates of temporal generalization: evidence for a two-process model of time perception.

In an event-related potential (ERP) study, brain correlates of temporal processing in the range of milliseconds were investigated by means of a dissociation paradigm. For this purpose, ten male and ten female subjects performed temporal and pitch generalization tasks with uni- and bidimensional stimulus variation. With difficulty held constant for both tasks, a larger frontally distributed negative slow wave was observed for pitch generalization relative to temporal generalization. This ERP pattern was consistent across uni- and bidimensional tasks of the present study but in direct contrast to prior ERP studies on temporal processing. Furthermore, for both uni- and bidimensional temporal tasks, within-task ERP analyses yielded amplitude modulation of centro-parietal P3b and fronto-central P500 as brain correlates of actively processed stimulus duration. Findings were consistent with a two-process model of temporal information processing based on a real-time comparison of the presented stimulus duration against an internal representation of the standard duration.

Adult↗

PubMed2004

Differential effects of prime-probe duration on positive and negative location priming: Evidence for opponent facilitatory and inhibitory influences in priming tasks.

A series of four spatial localization experiments is reported that examined the effects of display duration and presentation mode on positive and negative priming using an attended-repetition and an ignored-repetition paradigm, respectively. Experiment 1 showed larger positive priming with response-dependent than with 150 ms display durations while negative priming remained unaffected. Experiments 2-4 were performed to further elucidate the effects of prime-probe durations. Data suggest largely independent effects of prime and probe duration on priming effects. Manipulation of prime duration affected facilitation due to repetition of the prime distractor location as well as inhibitory effects associated with ignored repetition. Furthermore, anticipated probe duration modulated the effectiveness of inhibition of return. Findings are discussed within a framework proposing two major components of priming effects--a stimulus-driven or automatic component, and a strategic component related to the participant's expectations towards the probe.

Adult↗

PubMed2004

The application of jackknife-based onset detection of lateralized readiness potential in correlative approaches.

The onset of the lateralized readiness potential (LRP) represents an interesting parameter within mental chronometry. According to Miller, Patterson, and Ulrich (1998), reliability increases when LRP onsets are detected in jackknifed LRP waveforms. Until now, jackknifed LRP onsets could be analyzed in factorial designs only. The aim of the present study was to extend the application of jackknifing to correlative approaches (e.g., in personality research). Using different onset scoring techniques, in several simulations run on realistic LRP data jackknifing and single-subject procedures were compared regarding their estimates of a simulated true correlation. For all scoring techniques but regression, jackknifed coefficients were on average higher than the respective single-subject coefficients, and statistical power was higher. Overall, combining jackknifing with a 50%-relative onset criterion is recommended.

Algorithms↗

PubMed2004

Current-source density analysis of slow brain potentials during time estimation.

Two event-related potential studies were conducted to investigate differential brain correlates of temporal processing of intervals below and above 3-4 s. In the first experiment, 24 participants were presented with auditorily marked target durations of 2, 4, and 6 s that had to be reproduced. Timing accuracy was similar for all three target durations. As revealed by current-source density analysis, slow-wave components during both presentation and reproduction were independent of target duration. Experiment 2 examined potential modulating effects of type of interval (filled and empty) and presentation mode (randomized and blocked presentation of target durations). Behavioral and slow-wave findings were consistent with those of Experiment 1. Thus, the present findings support the notion of a general timing mechanism irrespective of interval duration as proposed by scalar timing theory and pacemaker-counter models of time estimation.

Acoustic Stimulation↗

PubMedDate not supplied

Dissociating aspects of temporal and frequency processing: a functional ERP study in humans.

An event-related potential (ERP) study was conducted, in order to dissociate brain functions associated with temporal information processing and processing of frequency information. Twelve participants were presented with both a temporal generalization and a pitch generalization task. In both tasks, exactly the same set of stimuli was presented to prevent stimulus-specific influences on ERP patterns. Participants had to decide whether or not an auditory stimulus matched a previously memorized standard stimulus, either with respect to pitch or duration. Analysis of ERPs revealed an increased negativity for the temporal discrimination task at fronto/central electrode sites. This effect was observed between 150 msec and 1,000 msec. At posterior sites, however, there was an increased positivity between 500 and 1,000 msec for the temporal generalization task. The differential topological activation patterns suggest more pronounced utilization of executive working-memory ressources for processing of temporal than for processing of pitch information.

Adult↗