Biomedical subjects

Helmfried E. Klein

Publications and source records attributed to Helmfried E. Klein.

4 recordsLinked to original sources

PubMed2003

[Single or Mixed Sex Wards in Psychiatric Hospital from the Patients' Viewpoint]

OBJECTIVE: Preference on separate or mixed sex treatment should be evaluated from the viewpoint of patients of a psychiatric hospital. METHODS: The preference of patients were surveyed by questionnaire before and after mixing four single sex wards. The adjusted response rate was 74.5 %. RESULTS: About 75 % of psychiatric patients prefer a mixed sex ward, about 25 % prefer a single sex ward. Females more frequently confirm the type of ward to whom they were actually allocated. By contrast, males are in favour for mixed sex wards independently of the presently experienced type of ward. Younger patients, voluntarily admitted patients, and patients with substance addiction prefer mixed sex wards. After mixing the sexes of formerly single sex wards a significant increase in preference of mixed sex wards was found, due to increased affirmation by female patients. CONCLUSION: If single sex wards can be established in a psychiatric hospital considering their size, specialisation of wards, and sector of care, patients are enabled to choose between a single and mixed sex ward at admission.

Journal Article↗

PubMed2003

[No Association of the - 141C Ins/Del Polymorphism of the Dopamine D2 Receptor with Schizophrenia]

Recently, a putative functional polymorphism (- 141C Ins/Del) in the 5'-flanking region of the dopamine D (2) receptor was found. An association of the Ins allele with schizophrenia has been described in a Japanese sample. In the present study this association was examined in a German schizophrenia patient population. In a family based approach 190 German family trios were analyzed for the - 141C Ins/Del genotype. Using the transmission disequilibrium test (TDT) we found no evidence for an association of the Ins allele with schizophrenia (TDT = 0.152, P = 0.696). In parallel, we performed an independent case control study with 268 schizophrenic patients and 244 controls. Again, we did not detect an overrepresentation of the Ins allele in patients (P = 0.124). Thus, our data do not support the hypothesis that the - 141C Ins variant plays a major role in predisposition to schizophrenia. To confirm our conclusion further preferentially family based studies are needed.

Journal Article↗

PubMed2003

["Acquired Psychopathy" and the Neurobiology of Emotion and Violence]

"Psychopathy" describes a type of personality disorder characterized by a dysregulation of emotion processing. Social behaviour, emotion regulation and competency are of particular relevance in forensic psychiatry. Structural-morphological and functional imaging studies prove that emotion regulation, aggressive-impulsive behaviour and learning from negative experiences are greatly influenced by frontal brain regions. These abilities are impaired in severe cases of dissocial personality disorders and in traumatic "pseudopsychopathy". We illustrate the importance functional neurobiological changes in patients personality disorders and "acquired psychopathy" by two case reports on patients who were admitted to a forensic-psychiatric facility for sexual crimes.

Journal Article↗

PubMed2003

[Editorial]

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Editorial↗