Biomedical subjects
Publications and source records attributed to Halina Batura-Gabryel.
A case of multiple brain tuberculosis in 32-year-old men was described. The diagnosis was made on the result of histopathological examination of excised tuberculoma. Basing on the described case, current possibilities of tuberculoma diagnostic difficulties, caused by unspecific clinical manifestation and atypical radiological lesions, was drawn.
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The level of activity of O6-alkylguanine-DNA-alkyltransferase (AGT), a DNA repair enzyme, in blood lymphocytes may be a marker of susceptibility to lung cancer. We measured the AGT activity level, expressed as pmoles of repaired bases/mg protein, in leukocytes of 153 lung cancer cases (of whom 80 were never smokers) and 106 controls (76 never smokers) enrolled in eight centres from seven countries. Subjects were interviewed with respect to active smoking and exposure to environmental tobacco smoke (ETS). Among never smokers, the odds ratios (ORs) of lung cancer were 1.3 (95% confidence interval 0.5-3.9), 1.5 (0.6-4.1) and 1.4 (0.5-3.8) in quartiles of decreasing AGT activity level, as compared to the upper quartile (P value of test for linear trend 0.6). Corresponding ORs among smokers were 3.4 (0.9-13), 2.0 (0.5-8.3) and 0.4 (0.1-1.6) (P value of test for linear trend 0.4). No interaction was suggested between AGT activity level and either cumulative smoking or exposure to ETS. Reduced AGT activity was not clearly associated with increased lung cancer risk in either smokers or non-smokers. However, the small size of our study argues for a prudent interpretation of our results.
UNLABELLED: The aim of the paper was evaluation of social aspects of tobacco smoking among Polish students. MATERIAL AND METHODS: The data from 671 students of Medical University and University in the age between 19 and 25 were collected using a specially prepared questionnaire. The following factors were analyzed: age and causes of first attempt of smoking, frequency of tobacco smoking in relation to the kind of high school and sex; students' behaviors connected with tobacco smoking and the knowledge of the consequences. RESULTS: 53.8% tried to smoke at least once. 23.09% of the students smoked regularly (10.73%) or occasionally (12.36%). University students smoked significantly more often than medical students--32.79% and 18.64% (p < 0.05), respectively. Males smoked more frequently than females (insignificant difference). The first smoking experience usually occurred at the age of 18, but males started to smoke earlier (between 10 and 14) than females (between 18 and 21)--significant differences. The age of 18 was the most common time when smoking became regular. Most smokers (80%) were aware of tobacco-dependent health disturbances. CONCLUSION: 1. Every fifth student of medicine and every third University student smoke cigarettes. 2. Anti-tobacco prevention should be started very early--before the age of 10 and continued up to the age of 21. Special attention should be taken at the age of 18 years as this time was found to be especially dangerous for development of addiction.